1.
Nat Rev Mol Cell Biol
; 6(1): 56-68, 2005 Jan.
Article
in English
| MEDLINE
| ID: mdl-15688067
ABSTRACT
A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.