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Nat Rev Mol Cell Biol ; 6(1): 56-68, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15688067

ABSTRACT

A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.


Subject(s)
Cell Movement/physiology , Protein-Tyrosine Kinases/physiology , Animals , Cell Membrane/physiology , Cytoskeletal Proteins/physiology , Cytoskeleton/physiology , Focal Adhesion Kinase 1 , Focal Adhesion Protein-Tyrosine Kinases , Humans , Intercellular Junctions/physiology , Paxillin , Phosphoproteins/physiology , Phosphorylation , Protein Structure, Tertiary , Proteins/physiology , Retinoblastoma-Like Protein p130
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