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1.
Zhonghua Nan Ke Xue ; 26(4): 346-350, 2020 Apr.
Article in Chinese | MEDLINE | ID: mdl-33351303

ABSTRACT

OBJECTIVE: To evaluate the efficacy and safety of Jiarong Tablets (JRT) combined with Testosterone Undecanoate Capsules (TUC) in the treatment of late-onset hypogonadism (LOH) in males. METHODS: This randomized open multicentered clinical trial included 200 cases of LOH meeting the inclusion, which were equally randomized into a control (aged ï¼»51.09 ± 5.6ï¼½ yr) and a trial group (aged ï¼»50.46 ± 5.2ï¼½ yr) to be treated with oral TUC (40 mg, bid) and TUC+JRT (0.92 g, tid) respectively for 12 successive weeks. We obtained the Aging Males' Symptoms (AMS) and IIEF-5 scores, serum total testosterone (TT) content, red blood cell (RBC) count, hepatic and renal function indexes and glucose and total PSA levels before and after treatment, and compared them between the two groups of patients. RESULTS: Totally, 191 of the LOH patients completed the experiment, 95 in the control and 96 in the trial group. After 12 weeks of treatment, the patients in the trial group, compared with the controls, showed significant improvement in the AMS score (20.6 ± 5.7 vs 31.9 ± 6.1, P < 0.05), IIEF-5 score (20.3 ± 3.1 vs 16.3 ± 3.8, P < 0.05) and serum TT level (ï¼»16.1 ± 3.9ï¼½ vs ï¼»12.7 ± 3.4ï¼½ nmol/L, P < 0.05). There were no significant adverse events or abnormalities in the RBC count, hepatic and renal functions, or glucose and total PSA levels in the two groups of patients before and after medication. CONCLUSIONS: JRT combined with TUC is safe and effective and superior to TUC alone in the treatment of LOH in males.


Subject(s)
Drugs, Chinese Herbal/therapeutic use , Hypogonadism , Testosterone/analogs & derivatives , Adult , Capsules , Humans , Hypogonadism/drug therapy , Male , Middle Aged , Tablets , Testosterone/therapeutic use , Treatment Outcome
2.
Zhonghua Nan Ke Xue ; 9(5): 350-1, 354, 2003 Aug.
Article in Chinese | MEDLINE | ID: mdl-14513642

ABSTRACT

OBJECTIVE: To evaluate the relationship between infection of Chlamydia Trachomatis(Ct) and apoptosis of spermatogenic cells. METHODS: Apoptotic spermatogenic cells were examined by Wright-Giemsa staining and the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate(dUTP)-biotin nick-end labeling(TUNEL) technique. RESULTS: Apoptosis rate of Ct infective group was significantly higher than that of normal group(P < 0.01). CONCLUSIONS: Ct infection may cause the apoptosis of spermatogenic cells, which affords an objective evidence for illustrating the mechanism of Ct-infection-induced male infertility.


Subject(s)
Apoptosis , Chlamydia Infections/pathology , Chlamydia trachomatis , Spermatocytes/pathology , Adult , Chlamydia Infections/complications , Humans , In Situ Nick-End Labeling , Infertility, Male/etiology , Male , Staining and Labeling
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