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Epidemiol Infect ; 146(3): 339-344, 2018 02.
Article in English | MEDLINE | ID: mdl-29345606

ABSTRACT

To optimise patients' outcomes and gain insight into transmitted drug resistance (TDR) among human immunodeficiency virus (HIV)-1 treatment-naive patients in Beijing, the prevalence of TDR was assessed. Demographic and clinical data of 1241 treatment-naive patients diagnosed between April 2014 and February 2015 were collected. TDR was defined using the Stanford University HIV drug resistance mutations database. The risk factors were evaluated by multi-logistic regression analysis. Among 932 successfully amplified cases, most were male (96.78%) and infected through men having sex with men (91.74%). Genotype were CRF01_AE (56.44%), B (20.60%), CRF07_BC (19.96%), C (1.61%) and other genotypes (1.39%). The overall prevalence of TDR was 6.12%. Most frequent mutations occurred in non-nucleoside reverse transcriptase inhibitors (NNRTIs) (3.11%), followed by protease inhibitors (PIs) (2.25%) and nucleoside reverse transcriptase inhibitors (NRTIs) (1.32%). Furthermore, HIV-1 genotype was associated with high risk of resistance, in which genotype C and other genotype may have higher risk for resistance. The prevalence among treatment-naive patients in Beijing was low. Resistance to NNRTIs was higher than with PIs or NRTIs. Continuous monitoring of regional levels of HIV-1 TDRs would contribute to improve treatment outcomes and prevent failures.


Subject(s)
Acquired Immunodeficiency Syndrome/epidemiology , Anti-HIV Agents/pharmacology , Drug Resistance, Viral/genetics , HIV-1/drug effects , Protease Inhibitors/pharmacology , Reverse Transcriptase Inhibitors/pharmacology , Acquired Immunodeficiency Syndrome/transmission , Adolescent , Adult , Aged , Aged, 80 and over , Beijing/epidemiology , HIV-1/genetics , HIV-1/physiology , Homosexuality, Male , Humans , Male , Middle Aged , Mutation , Prevalence , Young Adult
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