DINs: Deep Interactive Networks for Neurofibroma Segmentation in Neurofibromatosis Type 1 on Whole-Body MRI.

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that involves the central and peripheral nervous systems. Accurate detection and segmentation of neurofibromas are essential for assessing tumor burden and longitudinal tumor size changes. Automatic convolutional neural networks (CNNs) are sensitive and vulnerable as tumors' variable anatomical location and heterogeneous appearance on MRI. In this study, wepropose deep interactive networks (DINs) to address the above limitations. User interactions guide the model to recognize complicated tumors and quickly adapt to heterogeneous tumors. We introduce a simple but effective Exponential Distance Transform (ExpDT) that converts user interactions into guide maps regarded as the spatial and appearance prior. Comparing with popular Euclidean and geodesic distances, ExpDT is more robust to various image sizes, which reserves the distribution of interactive inputs. Furthermore, to enhance the tumor-related features, we design a deep interactive module to propagate the guides into deeper layers. We train and evaluate DINs on three MRI data sets from NF1 patients. The experiment results yield significant improvements of 44% and 14% in DSC comparing with automated and other interactive methods, respectively. We also experimentally demonstrate the efficiency of DINs in reducing user burden when comparing with conventional interactive methods.

Multi-branch fusion network for Myocardial infarction screening from 12-lead ECG images.

BACKGROUND AND OBJECTIVE: Myocardial infarction (MI) is a myocardial anoxic incapacitation caused by severe cardiovascular obstruction that can cause irreversible injury or even death. In medical field, the electrocardiogram (ECG) is a common and effective way to diagnose myocardial infarction, which often requires a wealth of medical knowledge. It is necessary to develop an approach that can detect the MI automatically. METHODS: In this paper, we propose a multi-branch fusion framework for automatic MI screening from 12-lead ECG images, which consists of multi-branch network, feature fusion and classification network. First, we use text detection and position alignment to automatically separate twelve leads from ECG images. Then, those 12 leads are input into the multi-branch network constructed by a shallow neural network to get 12 feature maps. After concatenating those feature maps by depth fusion, classification is explored to judge the given ECG is MI or not. RESULTS: Based on extensive experiments on an ECG image dataset, performances of different combinations of structures are analyzed. The proposed network is compared with other networks and also compared with physicians in the practical use. All the experiments verify that the proposed method is effective for MI screening based on ECG images, which achieves accuracy, sensitivity, specificity and F1-score of 94.73%, 96.41%, 95.94% and 93.79% respectively. CONCLUSIONS: Rather than using the typical one-dimensional electrical ECG signal, this paper gives an effective model to screen MI by analyzing 12-lead ECG images. Extracting and analyzing these 12 leads from their corresponding ECG images is a good attempt in the application of MI screening.