1.
Chem Commun (Camb)
; 53(29): 4124-4127, 2017 Apr 06.
Article
in English
| MEDLINE
| ID: mdl-28352858
ABSTRACT
(NHC)-Cu-catalyzed C(sp)-C(sp3) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C-O electrophiles. Mechanistic studies suggested that copper acetylide was the active species. Scale-up reactions further demonstrated the practicality and efficiency of the developed strategy.