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1.
Ars pharm ; 49(1): 31-37, 2008. ilus, tab
Article in Es | IBECS | ID: ibc-65747

ABSTRACT

Se analizaron extractos crudos y un ácido graso, ácido octadec-7-en-5-ynoic (1), de la corteza de la raíz de Cappariszeylanica Linn. (familia de las Capparidaceae) para observar sus actividades antibacterianas frente a la bacteria Gram positiva y Gram negativa. Entre los extractos crudos, el extracto de cloroformo mostró una buena actividad frente a todos los organismos de prueba. El ácido graso (1) aislado del extracto de cloroformo mostró actividades antibacterianas frente a todos los organismos de prueba, a excepción de E. coli. Las actividades se compararon con un antibiótico estándar: la kanamicina. Las concentraciones inhibitorias mínimas (CIH) de 1, determinadas mediante la técnica de dilución en serie, fueron 64 mg/ml frente a Bacillus subtilis y Shigella dysenteriae. Las actividades citotóxicas del extracto crudo y del ácido graso (1) se observaron mediante el bioensayo de gambas en salmuera yel valor de LC50 del compuesto fue 6,27 mg/ml (AU)


Crude extracts and a fatty acid, octadec-7-en-5-ynoic acid (1), from the root bark of Capparis zeylanica Linn. (Fam. Capparidaceae) were screened for their antibacterial activities against Gram positive and Gram negative bacteria. Among the crude extracts, chloroform extract showed good activity against all test organisms. The fatty acid (1) isolated from chloroform extract exhibited antibacterial activities against test organisms except E. coli. The activities were compared to a standard antibiotic- kanamycin. The minimum inhibitory concentrations (MICs) of 1, determined byserial dilution technique, were found to be 64 mg/ml against Bacillus subtilis and Shigella dysenteriae. The cytotoxic activities of crude extract and fatty acid (1) were observed by brine shrimp biassay and LC50 value of the compound was found to be 6.27 mg/ml (AU)


Subject(s)
Capparis , Capparis/microbiology , Capparis/toxicity , Plants, Medicinal/chemistry , Cytotoxicity, Immunologic , Herbicides/chemistry , Herbicides/pharmacology , Herbicides/toxicity , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/pharmacokinetics , Anti-Bacterial Agents/toxicity , Antibodies, Bacterial/pharmacology , Herbicides/metabolism , Herbicides/pharmacokinetics , Herbicides/therapeutic use , Cholera/therapy , Communicable Diseases/drug therapy
2.
J Colloid Interface Sci ; 217(1): 1-7, 1999 Sep 01.
Article in English | MEDLINE | ID: mdl-10441405

ABSTRACT

The results of studies on the interaction of binary mixtures of sodium deoxycholate (NaDC) and polyoxyethylene sorbitan monooleate (Tween 80) in bulk and at the air/water interface obtained from conductance, surface tension, and fluorescence measurements are described. The critical micelle concentration (CMC), thermodynamics of micellization, free energy of interfacial adsorption, minimum average area occupied by the surfactant species at the interface, micellar polarity, and aggregation number of the mixed aggregates have been determined. The mixed micellar composition and the estimation of the interacting forces involved are evaluated on the basis of recent theoretical models. The estimated interaction parameter indicates an overall attractive force in the mixed state, and the proportion of NaDC in the mixed micelle is found to be lower compared to the stoichiometric compositions. The mixed aggregates with higher mole fractions of NaDC show less stability in comparison with those having higher proportions of the nonionic component. Copyright 1999 Academic Press.

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