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Development ; 128(3): 437-46, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11152642

ABSTRACT

During the course of a systematic screening of peptide signaling molecules in Hydra magnipapillata, a novel peptide, Hym-323, which enhances foot regeneration was identified. The peptide is 16 amino acids long, and is encoded in the precursor protein as a single copy. Northern blot analysis, in situ hybridization analysis and immunohistochemistry showed that it was expressed in both ectodermal and endodermal epithelial cells throughout the body, except for the basal disk and the head region. The peptide enhanced foot regeneration by acting on epithelial cells. Lateral transplantation experiments indicated that the foot activation potential was increased in the peptide-treated tissue. These results suggest that Hym-323 is a peptide involved in a foot-patterning process in Hydra.


Subject(s)
Hydra/drug effects , Hydra/physiology , Peptides/pharmacology , Regeneration/drug effects , Amino Acid Sequence , Animals , Base Sequence , Body Patterning/drug effects , Cell Differentiation/drug effects , Cell Division/drug effects , Ectoderm/metabolism , Endoderm/metabolism , Epithelial Cells/cytology , Epithelial Cells/drug effects , Epithelial Cells/metabolism , Gene Expression Profiling , Head/physiology , Hydra/chemistry , Hydra/genetics , Immunohistochemistry , Molecular Sequence Data , Neurons/cytology , Neurons/drug effects , Peptides/chemistry , Peptides/genetics , Peptides/isolation & purification , Protein Precursors/chemistry , Protein Precursors/genetics , RNA, Messenger/genetics , RNA, Messenger/metabolism , Sequence Analysis, Protein , Time Factors , Tissue Transplantation
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