[Sweet syndrome following therapeutic use of granulocyte colony stimulating factor]. / Granulocyta colonia stimuláló faktor terápia mellett kialakuló Sweet-szindróma.

Sweet's syndrome is an acute febrile neutrophilic dermatosis. Classical form occurs after infection of the gastrointestinal or respiratory tract. This syndrome is often associated with myeloproliferative disorders and solid tumors. Some cases are reported in the literature in which usage of granulocyte colony-stimulating factor induced the symptoms of Sweet's syndrome. We report the case of an 53-year-old woman with hyperthyreosis. She wasn't euthyreoid in spite of medicaments since 1994, so her doctors planned operation. In the preoperative period her peripheral blood revealed agranulcytosis and she has got fever. 2 days after administration of granulocyte colony-stimulating factor erythematous plaques appeared on her face, neck and extremities. Biopsy from these plaques showed dermal neutrophilia, so a diagnosis of neutrophilic dermatosis was made. After the administration of corticosteroids, immunglobulin and antibiotics the skin lesions were resolved. She was examined because of suspicion of autoimmune diseases but we couldn't find any of them. Retrospectively, appearance of Sweet's syndrome was associated with granulocyte colony-stimulating factor. The case of this woman is important because usage of colony-stimulating factors is widespread and the Sweet's syndrome could be occurs as side effect of these drugs.

[Changes in indications for liver biopsy]. / Die Veränderung der Problematik der Leberbiopsien.

The author tries to analyse the modification of the indication to the needle biopsy of the liver. The clinician still only rarely demands from the pathologist the verification of an acute hepatitis and the proof of an obstruction. On the other hand a differentiation of persisting and aggressive hepatitis is possible only by a morphological investigation. Nowadays the tasks of the pathologist are mainly the confirmation or the exclusion of liver lesions caused by alcohol or pharmaceutical products and chemicals, respectively, and the diagnosis of a pseudo-alcoholic hepatitis.

[Ruptured myocardial infarcts]. / Untersuchungen an rupturierten Herzinfarkten.

Forty one cardiac rupture complicating acute myocardial infarction (AMI) were studied in a ten-year period. The anterior AMIs are most likely to be observed with ruptures. The interval from the onset of AMI to the clinical detection of rupture was short (acute period). Some factors such as physical work in the acute period and transmural infarctions strongly infiltrated with leukocytes cause a higher frequency of rupture. Diabetes and hypertension might be predisposing factors.

[7 cases of polyarteritis nodosa]. / Polyarteriitis nodosa 7 esete.

The recognition of polyarteriitis nodosa is a difficult task for the clinician. The extraordinarily varied symptoms of this illness involve mostly general complaints and the mostley combination of some organic symptoms. In their histologically proved seven cases the most frequent original clinical symptoms were the long lasting feverish condition, the loss of body weight as well as numbness and pain of limbs. The anamnesis of three patients involved the asthma bronchiale. The laboratory findings were characterized first of all by an accelerated erythrocyte sedimentation rate and in four cases anaemia has developed. In four cases eosinophilia and in two ones high blood-pressure were observed. The disease-process of their patients is varying; a 30 year old man's death was caused right after the admission to the hospital by an acute myocardial infarction.

[Clinico-pathological observations in myocardial rupture]. / Szívizom-rupturával kapcsolatos klinikopatológiai megfigyeléseink.

In their material of 10 years authors describe 42 myocardial ruptures developed as complication of acute myocardial infarct. The rupture developed in the acute stage of infarct. Rupture of anterior wall infarct is the most frequent. The most decisive clinical factor in development of rupture is the loading in acute stage, from pathologic aspect the strongly infiltrated, transmural infarct is considered the most decisive pathologic factor. Diabetes mellitus and hypertonia can predispose to myocardial rupture.

[Pathomorphology of lung changes caused by gramoxone poisoning. Human pathologic and animal experimental studies]. / Pathomorphologie der durch Gramoxonvergiftung bedingten Lungenveränderungen. Humanpathologische und tierexperimentelle Untersuchungen.

An account is given in this paper of changes caused by Gramoxone, a week killer, to the human lung as well as to experimental material. The process of damage was found to depend on the amount of toxic substance involved and on the route of uptake. Fibrosis, eventually, is the greatest danger. Intraperitoneal application leads to squamous epithelium metaplasia in the lung.

[Simultaneous occurrence of malignant lymphoma and carcinoma in the stomach]. / Gleichzeitiges Vorkommen von malignem Lymphom und Karzinom im Magen.

The simultaneous occurrence of malignant lymphoma and carcinoma of the stomach is described. The lymphoma proved to be of a high degree of malignancy. The malignant lymphoma was considered to be a primary tumor, followed by the development of the carcinoma. The patient survived for eight months after operation.

[Importance of environmental factors for the development of liver cirrhosis]. / Uber die Bedeutung der Umweltfaktoren bei der Entwicklung der Leberzirrhose.

The frequency of cirrhoses drastically increased in the seventies. This increase was predominantly due to an augmentation of alcoholic cirrhosis in men. Cirrhosis is significantly more wide-spread in men than in women. Most of the cirrhoses in women are of unknown origin. Morphologically, the alcoholic cirrhoses are of the micronodular types in their great majority. Combined with HBsAg positivity, the macronodular type is most frequent. The classification in micro- and macronodular cirrhoses do not imply a different etiology but it may indicate different stages in cirrhosis of identic origin. Histologically, the signs of alcoholic hepatitis particularly help to trace back the alcoholic etiology. If HBsAg can be detected and the margins of the pseudolobules are moth- eatenlike , this speaks for a hepatitic origin. The lowest average age was observed in cases of alcoholic cirrhoses, the highest in HBsAg positive cirrhoses of women. Men suffering from cirrhosis die earlier than women. In the case of alcoholic origin, the bulk of the cirrhotic livers are eutrophic while, beside HBsAg positivity, the atrophic livers are prevailing. The two most frequent environmental causes of cirrhosis are alcoholic beverages and hepatitis. Better exploration of the environmental factors and clearing up the origin of cryptogenic cirrhoses are essential tasks of the future.

Infantile and juvenile cirrhosis of the liver.

In 14 years necropsy material 12 cases of infantile and 2 of juvenile liver cirrhosis occurred. In early infancy, diffuse cirrhosis is the most characteristic, whereas in more advanced age cirrhosis of irregular type is more frequent. The posthepatitic, secondary biliary, metabolic and cryptogenic cirrhoses are discussed from aetiological aspects.