ABSTRACT
To gain better understanding of systemic lupus erythematosus (SLE) in Dubai we studied the clinical and immunological manifestations in a cohort of 151 patients attended Rheumatology Clinic in Dubai Hospital between January 2002 and January 2007. We found that the female to male ratio was 20.5:1, with a mean age of 35.5 years (0.9). The mean age at disease onset was 28.9 years (0.8) and mean disease duration 6.7 years (0.4). Five-year survival rate in our cohort was 94%. The commonest clinical manifestations in this cohort were arthritis (88%), haematological abnormalities (61.6%), and malar rash (60.3%). Leucopenia, fever, hair loss and proteinuria were observed in approximately half of the patients. Anaemia was found in 44.3% but only 9.9% had haemolytic anaemia. Photosensitive rash was seen in 43% of patients. Approximately one-third of the patients had serositis and mouth ulcers, 30.5 and 27.2% respectively. Vasculitis was observed in 19.2% of patients. Neuropsychiatric manifestations (15.9%), discoid lupus lesions (12.6%), and brain infarcts (13.2%) were infrequent. Subacute cutaneous lupus (6%) was also uncommon. Anti-nuclear antibodies were detected in 98%, anti-double stranded DNA antibodies in 88.7%, anti-Sm antibodies in 19.7%, anti-RNP in 40.4%, anti-Ro antibodies in 52.3% and anti-La antibodies in 19.8%. Anti-cardiolipin IgM and IgG were detected in 25.3 and 22.4%, respectively. This study suggests that Arabs with SLE residing in Dubai have comparable clinical features to their counterparts in other Arab countries and Western countries. The high prevalence of positive anti-Ro antibodies among our Arab patients probably reflects a character, that is, commonly seen in SLE patients of Middle East origin.
Subject(s)
Asian People/statistics & numerical data , Autoantibodies/blood , Lupus Erythematosus, Systemic/ethnology , Urban Population/statistics & numerical data , Adult , Cohort Studies , Female , Humans , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/immunology , Lupus Erythematosus, Systemic/mortality , Male , United Arab Emirates/epidemiologyABSTRACT
Background: Historical and anthropological data suggest the presence of descendents of Changos, Cuncos, Chonos and Yamanas, South American indian populations, in certain Chilean coastal villages. Aim: To assess the degree of South American indian admixture in Chilean coastal villages using protein markers, to complete the assessment of human biological diversity in Chile. Subjects and methods: AB0, Rh, MNS, Duffy and Kidd blood group systems were assessed in 47, 48, 55 and 24 individuals from Paposo, Carelmapu, Laitec and Ukika respectively. Phenotypic and gene frequencies were calculated. The degree of South American indian admixture was estimated from the AB0*0 allele and Rh*dce haplotypes. Results: High frequencies of AB0*0, Fy*a, Jk*b alleles, Dce and Ms haplotypes were found in all villages, consistent with the pattern expected for South AmericanAboriginal populations. The highest presence of South American indian admixture was present in Laitec with 80 per cent and in Ukika with 74 per cent. The figures for Paposo and Carelmapu were 60 and 65 per cent respectively. Conclusions: Accordin g to South American indian admixture estimates, the genetic isolation of coastal populations is lower than that of inland subjects, suggesting thatsea proximity facilitates gene flow
Subject(s)
Humans , Male , Female , Genetics, Population , Genetic Markers , Back , Gene Frequency/genetics , Rural Population , ABO Blood-Group System/isolation & purification , Kidd Blood-Group System/isolation & purification , Duffy Blood-Group System/isolation & purification , MNSs Blood-Group System/isolation & purification , Rh-Hr Blood-Group System/isolation & purificationABSTRACT
The genetic composition of a group of 24 Yamana indians that survive in Puerto Williams, navarino Island, Chile (parallel 55 south of Tierra del Fuego), was studied. Results showed that these indians have a different genetic composition than Pehuenche indians, specially for HLA system and sterase D. This fact validates the hypothesis based on archeological and antropological evidence, about the paleoindian origin of Yamanas
Subject(s)
Indians, South American/genetics , Gene Frequency/genetics , Phosphoglucomutase/genetics , Haptoglobins/genetics , Esterases/genetics , Major Histocompatibility Complex/genetics , Anthropology, Cultural/trends , Electrophoresis, Starch Gel , Genetics, Population , Blood Group Antigens/genetics , Hemagglutination TestsABSTRACT
Se realiza un estudio de distribución de grupos sanguíneos ABO y Rh en 2734 parejas de hermanos consecutivos nacidos en el Hospital Clínico de la Universidad de Chile y en Clínica Alemana, de Santiago. Las proporciones esperadas de las distintas parejas hermano-hermano para el grupo ABO se calcularon según el método de matrices ITO para hermanos. La distribución de las distintas parejas de hermanos se alejó significativamente de lo esperado: 1§) hubo mayor cantidad de segundos hermanos grupo B que primeros; 2§) hubo exceso de individuos en los casilleros A-B (primer hermano A - segundo hermano B) y A-O en la muestra del Hospital Clínico de la Universidad de Chile; 3§) hubo ausencia de elementos en el casillero B-A de la muestra de Clínica Alemana. Estas distorsiones fueron evidentes sólo cuando ambos hermanos eran Rh(+)
Subject(s)
Pregnancy , Infant, Newborn , Humans , Female , Gene Frequency , ABO Blood-Group System/genetics , Rh-Hr Blood-Group System/genetics , Immunologic Memory , PhenotypeABSTRACT
La hipótesis que los sistemas sanguíneos ABO y Rh y el sexo segreguen independientemente fue probada en una muestra de escolares, en la que algunas distorsiones del sistema ABO habían sido observadas. Se encontró heterogeneidad de la proporción de individuos O en las comparaciones pareadas entre grupos Rh y sexos, al estudiarlas por las pruebas, z, t y probabilidades exactas, pero no con la prueba de x2, los varones tuvieron una menor proporción de grupo O; los varones portadores del haplotipo cde presentaron una menor frecuencia de O, hecho que no se dio en las mujeres. El grupo RH8 (cDE/cde) tuvo una menor frecuencia de O que el resto y no se encontraron individuos BRH8
Subject(s)
Child , Humans , Male , Female , Gene Frequency , ABO Blood-Group System/genetics , Rh-Hr Blood-Group System/genetics , ChileSubject(s)
Infant, Newborn , Humans , Male , Female , Genetic Variation , Genetics, Population , Blood Group AntigensABSTRACT
Se estudian algunas proteinas plasmaticas y eritrocitarias mediante electroforesis.Se describen los fenotipos de haptoglobina (Hp), esterasa D (ESD) y fosfoglucomutasa (PGM1) y las cantidades absolutas y porcentuales de proteinas totales, albuminas, alfa 1, alfa 2, beta y gamma globulinas presentes en el plasma.Se encontro una variante de ESD. Las mujeres tienen valores superiores de gamma globulina plasmatica
Subject(s)
Child , Humans , Male , Female , Blood Proteins , ErythrocytesABSTRACT
Se describen los promedios, desviaciones tipicas, correlaciones y distribuciones de proteinemia, ferremias, capacidad total de fijacion de hierro, capacidad latente de fijacion de hierro, hematocrito, cantidad de hemoglobina y concentracion de hemoglobina corpuscular media, encontrados en una amuestra de aproximadamente 200 varones y 200 mujeres escolares del Area Norte de Santiago. Se describen ademas la relacción de estas variables con la edad que fluctuo entre 9 y 13 años
Subject(s)
Iron , Blood Proteins , Hematocrit , HemoglobinsABSTRACT
Se examina el sistema sanguineo Rh en una muestra de ninos del Area Norte de Santiago.Los antisueros utilizados fueron: antiC, antic, antiD, antiE y antie. 73 parejas de hermanos quedaron incluidas en la muestra, los hermanos no tienen mas de tres anos de diferencia en edad que sus respectivos casos indices. Los casos indices presentaron frecuencias superiores de RH3(CDe/CDe) e inferiores de RH5(CDe/cDE) y RH6(CDe/cde) que las encontradas en la muestra de hermanos. De l7 parejas de hermanos donde los indices pertenecian al grupo RH3, solo un hermano tuvo ese mismo fenotipo,el resto se distribuyo en: RH5, RH6, RH7(cDE/cDE, 1) y Rh18 (cde/cde, 1). La probabilidad de produccion al azar de este resultado es P<0.00002. Para explicar estos resultados, postulamos que hay un sistema mayor de histocompatibilidad asociado al sistema Rh en el cromosoma 1 humano