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1.
J Biomed Opt ; 19(3): 35007, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24658776

ABSTRACT

There is an increasing use of high-power fiber lasers in manufacturing and telecommunications industries operating in the infrared spectrum between 1000 and 2000 nm, which are advertised to provide as much as 10 kW continuous output power at 1070 nm. Safety standards have traditionally been based on experimental and modeling investigations with scant data available for these wavelengths. A series of studies using 1070-nm infrared lasers to determine the minimum visible lesion damage thresholds in skin using the Yucatan miniature pig (Sus scrofa domestica) for a range of beam diameters (0.6, 1.1, 1.9, 2.4, 4.7, and 9.5 cm) and a range of exposure durations (10 ms to 10 s) is presented. Experimental peak temperatures associated with each damage threshold were measured using thermal imaging. Peak temperatures at damage threshold for the 10-s exposures were ∼10°C lower than those at shorter exposures. The lowest and highest experimental minimum visible lesion damage thresholds were found to have peak radiant exposures of 19 and 432 J/cm2 for the beam diameter-exposure duration pairs of 2.4 cm, 25 ms and 0.6 cm, 10 s, respectively. Thresholds for beam diameters >2.5 cm had a weak to no effect on threshold radiant exposure levels for exposure times ≤0.25 s, but may have a larger effect on thresholds for exposures ≥10 s.


Subject(s)
Infrared Rays/adverse effects , Lasers/adverse effects , Radiation Dosage , Skin , Animals , Female , Radiation Injuries/pathology , Skin/injuries , Skin/pathology , Skin/radiation effects , Swine , Swine, Miniature , Temperature
2.
J Biomed Opt ; 18(12): 125002, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24343435

ABSTRACT

A series of experiments were conducted in vivo using Yucatan miniature pigs (Sus scrofa domestica) to determine thermal damage thresholds to the skin from 1319-nm continuous-wave Nd:YAG laser irradiation. Experiments employed exposure durations of 0.25, 1.0, 2.5, and 10 s and beam diameters of ∼0.6 and 1 cm. Thermal imagery data provided a time-dependent surface temperature response from the laser. A damage endpoint of fifty percent probability of a minimally visible effect was used to determine threshold for damage at 1 and 24 h postexposure. Predicted thermal response and damage thresholds are compared with a numerical model of optical-thermal interaction. Resultant trends with respect to exposure duration and beam diameter are compared with current standardized exposure limits for laser safety. Mathematical modeling agreed well with experimental data, predicting that though laser safety standards are sufficient for exposures <10 s, they may become less safe for very long exposures.


Subject(s)
Lasers, Solid-State/adverse effects , Radiation Dosage , Radiation Injuries , Skin/radiation effects , Animals , Female , Models, Theoretical , Swine , Swine, Miniature
3.
J Biomed Opt ; 15(6): 065008, 2010.
Article in English | MEDLINE | ID: mdl-21198172

ABSTRACT

A series of experiments are conducted in vivo using Yucatan mini-pigs (Sus scrofa domestica) to determine thermal damage thresholds to the skin from 1940-nm continuous-wave thulium fiber laser irradiation. Experiments employ exposure durations from 10 ms to 10 s and beam diameters of approximately 4.8 to 18 mm. Thermal imagery data provide a time-dependent surface temperature response from the laser. A damage endpoint of minimally visible effect is employed to determine threshold for damage at 1 and 24 h postexposure. Predicted thermal response and damage thresholds are compared with a numerical model of optical-thermal interaction. Results are compared with current exposure limits for laser safety. It is concluded that exposure limits should be based on data representative of large-beam exposures, where effects of radial diffusion are minimized for longer-duration damage thresholds.


Subject(s)
Burns/etiology , Burns/physiopathology , Environmental Exposure/adverse effects , Radiation Injuries/etiology , Radiation Injuries/physiopathology , Skin/injuries , Skin/radiation effects , Animals , Computer Simulation , Differential Threshold/radiation effects , Dose-Response Relationship, Radiation , Infrared Rays/adverse effects , Models, Biological , Radiation Dosage , Skin/physiopathology , Skin Temperature/radiation effects , Swine , Swine, Miniature
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