ABSTRACT
We report a case of botfly myiasis presenting as an ankle cellulitis in a teenager returning from Guyana. Main clinical features and therapeutic approaches are described.
Subject(s)
Insect Bites and Stings/diagnosis , Myiasis/diagnosis , Adolescent , Animals , Anti-Bacterial Agents/therapeutic use , Argentina , Diptera , France , Guyana , Humans , Insect Bites and Stings/drug therapy , Larva/drug effects , Male , Mexico , Myiasis/drug therapy , Myiasis/transmission , TravelABSTRACT
Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder due to alpha-L-iduronidase deficiency. Its severe prognosis has been significantly improved by enzyme replacement therapy using recombinant human alpha-L-iduronidase (laronidase). We report the case of a boy who was diagnosed at 19 months of age with Hurler's disease, the most severe form of MPS I, and received thereafter a treatment by laronidase, resulting in clinical and biological improvement. The aim of this case report is to draw physicians' attention on the presenting signs of Hurler's disease, in order to enable an earlier diagnosis, increasing the treatment's benefits.
Subject(s)
Iduronidase/therapeutic use , Mucopolysaccharidosis I/drug therapy , Child , Diagnosis, Differential , Follow-Up Studies , Humans , Infant , Mucopolysaccharidosis I/diagnosis , Treatment OutcomeABSTRACT
Long-term low dose azithromycin treatment in cystic fibrosis patients with chronic Pseudomonas aeruginosa infection is safe and reduces the decline in lung function, the number of acute exacerbations and improves nutritional status; underlying efficacy mechanisms are multiple and synergistic.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Azithromycin/therapeutic use , Cystic Fibrosis/complications , Pseudomonas Infections/drug therapy , Child , Humans , Pseudomonas Infections/etiologyABSTRACT
Acute arteriopathies are the etiological factor of 25% of all the cerebral arterial thrombosis cases in childhood; they give way to ischemic strokes which have specific clinical and radiological features; varicella is the etiologic factor in 60% of the cases; favorable outcome is the rule; physiopathology and treatment remain under discussion.