ABSTRACT
Interstitial pulmonary fibrosis and bullae are uncommon findings in neurofibromatosis. A case of this disease with pulmonary parenchymal involvement is presented and the association between the two is discussed.
Subject(s)
Lung Diseases/complications , Neurofibromatosis 1/complications , Pulmonary Fibrosis/complications , Humans , Male , Middle AgedABSTRACT
A 17-year-old Coloured youth presented at Tygerberg Hospital on six occasions between 1978 and 1981. He was admitted three times for meningococcal meningitis and three times for a meningitic illness clinically suggestive thereof. He had been admitted twice before to the City Hospital, Cape Town, in 1966 and 1968, for presumed meningococcal meningitis. He was fully evaluated in the outpatient department and found to have no detectable total haemolytic complement activity. There was no evidence of classic or alternative pathway activation. He has been tentatively designated as having a deficiency in the C6 or C8 components of the terminal membrane attack mechanism of the complement cascade.
Subject(s)
Complement System Proteins/analysis , Meningitis, Meningococcal/immunology , Adolescent , Complement C3/analysis , Complement C4/analysis , Humans , Male , RecurrenceABSTRACT
A 31-year-old Coloured man was admitted to Tygerberg Hospital in 1981 with hoarseness, hyperkeratotic skin lesions and nodules on the eyelids. There was a history of an episode of loss of consciousness. Skull radiographs demonstrated bilateral symmetrical calcifications in the temporal region. Skin biopsy was consistent with a diagnosis of lipoid proteinosis.
