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A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus.

Herz, Matthias; Johns, Don; Reviriego, Jesus; Grossman, Loren D; Godin, Chantal; Duran, Santiago; Hawkins, Federico; Lochnan, Heather; Escobar-Jiménez, Fernando; Hardin, Philip A; Konkoy, Christopher S; Tan, Meng H.

Clin Ther ; 25(4): 1074-95, 2003 Apr.

Article in English | MEDLINE | ID: mdl-12809958

ABSTRACT

OBJECTIVE: The goal of this study was to compare the effects of 2 doses of pioglitazone hydrochloride (a thiazolidinedione insulin sensitizer) with placebo on glycated hemoglobin (HbA(1c)), insulin sensitivity, and lipid profiles in patients with type 2 diabetes mellitus who had suboptimal glycemic control and mild dyslipidemia. METHODS: Patients with type 2 diabetes mellitus (HbA(1c) >/=6.5% and /=7% to <8%) or high (>/=8% to

Subject(s)

Diabetes Mellitus, Type 2/drug therapy , Hyperlipidemias/complications , Hypoglycemic Agents/therapeutic use , Thiazoles/therapeutic use , Thiazolidinediones , Adult , Aged , Aged, 80 and over , Blood Glucose/metabolism , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/metabolism , Dose-Response Relationship, Drug , Double-Blind Method , Female , Glycated Hemoglobin/metabolism , Humans , Hyperlipidemias/blood , Hypoglycemic Agents/administration & dosage , Hypoglycemic Agents/adverse effects , Insulin/blood , Lipids/blood , Male , Middle Aged , Pioglitazone , Thiazoles/administration & dosage , Thiazoles/adverse effects , Treatment Outcome

ABSTRACT

Subject(s)

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