ABSTRACT
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Subject(s)
Middle Aged , Adult , Aged, 80 and over , Aged , Male , Female , Humans , Neck , Retrospective Studies , Lymphatic Metastasis , Laryngeal NeoplasmsABSTRACT
In order to assess the main clinical factors predicting extracapsular spread (ECS) in neck lymph nodes of patients with laryngeal cancer, step-wise logistic regression (LR) was applied to data retrospectively obtained from 141 patients surgically treated. Thirty six variables were evaluated in each patient. One hundred twenty eight out of the 141 patients had complete information on the 36 variables studied. With data from these 128 patients a linear discriminant function was obtained with an overall accuracy of 65.4%. The rate of correct prediction was 60.8% for presence of ECS and 71.7% for absence of ECS. Only 3 secondary variables created out of the 36 employed for the analysis were necessary to obtain these results.
Subject(s)
Laryngeal Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Lymphatic Metastasis , Male , Middle Aged , Neck , Retrospective StudiesABSTRACT
OBJECTIVE: To investigate the incidence and characteristics of lymphoproliferative disorders of Waldeyer's ring in our pediatric patients. MATERIAL AND METHODS: We retrospectively reviewed 20 children under 14 years of age who underwent surgery in our department for adenoidectomy and/or tonsillectomy between 1 January 1996 and 30 November 2000. In non-immunocompromised children, surgical indication was the recent development of progressive unilateral tonsillar hyperplasia, and in immunocompromised patients indication was mainly the enlargement of adenoids and/or tonsils, although eradication of local Ebstein-Barr virus infection and recurrent acute tonsillitis were also indications. RESULTS: The mean age was 4.6+/-2.3 years (range: 16.9 months-13.9 years). Sixteen patients (80.0 %) were male. In the nine patients with unilateral hyperplasia, histopathological diagnosis was diffuse lymphoid hyperplasia. Of the 11 immunocompromised patients, 5 (45.5 %) had some type of lymphoproliferative disorder. DISCUSSION AND CONCLUSIONS: Lymphoproliferative disorders of Waldeyer's ring are relatively frequent in immunocompromised children who have undergone surgery of the adenoids and/or tonsils. Although no cases of unilateral hyperplasia of the tonsils were diagnosed in our series, tonsillectomy is indicated in patients with this diagnosis, independent of their immunological status.
Subject(s)
Lymphoproliferative Disorders/pathology , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Retrospective StudiesABSTRACT
Objetivo: Investigar la incidencia y características de los procesos linfoproliferativos del anillo de Waldeyer en pacientes pediátricos. Material y métodos: Se recogieron retrospectivamente 20 pacientes menores de 14 años intervenidos en nuestro servicio de adenoidectomía y/o amigdalectomía entre el 1 de enero de 1996 y el 30 de noviembre de 2000. La indicación en niños no inmunodeprimidos fue la aparición de una hiperplasia unilateral reciente y progresiva de amígdala y en el caso de inmunodeprimidos fue principalmente el crecimiento adeno y/o amigdalar, aunque también se intervinieron para erradicar infección focal por el virus de Epstein-Barr y por amigdalitis de repetición. Resultados: La media de edad fue de 4,6 ± 2,3 años (límites, 16,9 meses-13,9 años). Del total de los pacientes de nuestra serie, 16 fueron varones (80,0 %). El diagnóstico anatomopatológico de los 9 pacientes con hiperplasia unilateral de amígdala fue hiperplasia folicular linfoide. Por otro lado, en 5 de los 11 sujetos con inmunodeficiencias (45,5 %) se evidenció algún tipo de proceso linfoproliferativo. Discusión y conclusiones: Los procesos linfoproliferativos del anillo de Waldeyer son relativamente frecuentes en niños inmunodeprimidos intervenidos de adenoides y/o amígdalas. Aunque no se diagnosticó ningún caso en nuestra serie, consideramos conveniente operar a sujetos pediátricos con hiperplasia unilateral de amígdala, con independencia de su estado inmunológico (AU)
Subject(s)
Child , Child, Preschool , Adolescent , Male , Infant , Female , Humans , Retrospective Studies , Lymphoproliferative DisordersABSTRACT
A study was made of the impact of the presence of extracapsular spread (ECS) and desmoplastic pattern (DP) in cervical lymph nodes on local recurrence in 119 patients with laryngeal and hypopharyngeal cancer. All patients underwent surgery between 1984 and 1992 for squamous-cell carcinoma and had histologically confirmed lymph node metastasis. The tumor recurred locally in 15.7% of patients without ECS and in 36.1% of patients with ECS (p < 0.03). The frequency of local recurrence did not differ significantly between patients without DP (20.0%) and patients with DP (29.0%) (p > 0.05). Therefore ECS in cervical lymph nodes of patients with laryngeal cancer was related with an increased rate of local recurrence, but DP did not modify the probability of local recurrence.
Subject(s)
Carcinoma, Squamous Cell/pathology , Hypopharyngeal Neoplasms/pathology , Laryngeal Neoplasms/pathology , Neoplasm Recurrence, Local/pathology , Adult , Aged , Aged, 80 and over , Female , Fibrosis , Humans , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Staging , Retrospective StudiesABSTRACT
OBJECTIVE: To describe an additional case of rapidly growing leiomyoma of the bladder in a pregnant woman. METHODS: A case of leiomyoma of the bladder in a woman at 8 months of pregnancy is presented. Transurethral resection was performed, but the tumor recurred a few weeks later. The tumor was resected by partial cystectomy after delivery. CONCLUSIONS: Leiomyoma of the bladder is an uncommon benign lesion that is successfully managed by surgical resection. The rapid recurrence of the tumor in our patient can be ascribed to the hormonal changes during pregnancy.
Subject(s)
Leiomyoma/diagnosis , Pregnancy Complications, Neoplastic/diagnosis , Urinary Bladder Neoplasms/diagnosis , Adult , Cystectomy/methods , Female , Humans , Leiomyoma/surgery , Neoplasm Recurrence, Local/diagnosis , Neoplasm Recurrence, Local/surgery , Pregnancy , Pregnancy Complications, Neoplastic/surgery , Pregnancy Trimester, First , Time Factors , Urinary Bladder Neoplasms/surgeryABSTRACT
Hyalinizing trabecular adenoma (HTA) is a follicle-derived tumor of the thyroid gland that has been described recently. The differential diagnosis includes medullar carcinoma, papillary carcinoma, and paraganglioma of the thyroid. We report a case of thyroid HTA in a 25-year-old woman. The tumor appeared as a <
Subject(s)
Adenoma/pathology , Hyalin/metabolism , Thyroid Neoplasms/pathology , Adenoma/surgery , Adult , Diagnosis, Differential , Female , Humans , Stromal Cells/pathology , Thyroid Neoplasms/surgeryABSTRACT
The influence of the extracapsular spread (ECS) of metastatic cervical lymph nodes in patients with laryngeal cancer is discussed. The study included 119 patients who underwent surgery between 1984 and 1992 for squamous cell carcinoma of the larynx and lymph node metastasis confirmed by histology. Results were studied from two main aspects: survival and cervical recurrence. The 3-year survival rate was 73.4% in patients without ECS and 28.9% in patients with ECS (p < 0.001). The 3-year local recurrence rate differed significantly: 23.5% in patients without ECS and 58.3% in patients with ECS (p < 0.001). These results showed that ECS had an unfavorable prognostic significance for lymph node metastasis of laryngeal cancer.
