[Investigations of a controlled, decision tree based procedure for Selective Dry Cow Treatment in Bavarian dairy farms]. / Untersuchungen zu einem kontrollierten, entscheidungsbaumbasierten Verfahren des Selektiven Trockenstellens in Bayerischen Milchviehbetrieben.

OBJECTIVE: Four parameters of a decision tree for Selective Dry Cow Treatment (SDCT), examined in a previous study, were analyzed regarding their efficacy in detecting cows for dry cow treatment (DCT, use of intramammary antimicrobials). This study set out to review wether all parameters (somatic cell count [SCC≥ 200 000 SC/ml 3 months' milk yield recordings prior dry off (DO)], clinical mastitis history during lactation [≥1 CM], culturing [14d prior DO, detection of major pathogens] and California-Mastitis-Test [CMT, > rate 1/+ at DO]) are necessary for accurate decision making, whether there are possible alternatives to replace culturing, and whether a simplified model could replace the decision tree. MATERIAL AND METHODS: Records of 18 Bavarian dairy farms from June 2015 to August 2017 were processed. Data analysis was carried out by means of descriptive statistics, as well as employing a binary cost sensitive classification tree and logit-models. For statistical analyses the outcomes of the full 4-parameter decision tree were taken as ground truth. RESULTS: 848 drying off procedures in 739 dairy cows (CDO) were included. SCC and CMT selected 88.1%, in combination with CM 95.6% of the cows that received DCT (n=494). Without culturing, 22 (4.4%) with major pathogens (8x Staphylococcus [S.] aureus) infected CDO would have been misclassified as not needing DCT. The average of geometric mean SCC (within 100 d prior DO) for CDO with negative results in culturing was<100 000 SC/ml milk, 100 000-150 000 SC/ml for CDO infected with minor pathogens, and ≥ 150 000 SC/ml for CDO infected with major pathogens (excluding S.aureus). Using SCC during lactation (at least 1x > 200 000 SC/ml) and positive CMT to select CDO for DCT, contrary to the decision tree, 37 CDO (4.4%) would have been treated "incorrectly without" and 43 CDO (5.1%) "unnecessarily with" DCT. Modifications were identified, such as SCC<131 000 SC/ml within 100 d prior to DO for detecting CDO with no growth or minor pathogens in culturing. The best model for grading CDO for or against DCT (CDO without CM and SCC<200 000 SC/ml [last 3 months prior DO]) had metrics of AUC=0.74, Accuracy=0.778, balanced Accuracy=0.63, Sensitivity=0.92 and Specificity=0.33. CONCLUSIONS: Combining the decision tree's parameters SCC, CMT and CM renders suitable selection criteria under the conditions of this study. When omitting culturing, lower thresholds for SCC should be considered for each farm individually to select CDO for DCT. Nonetheless, the most accurate model could not replace the full decision tree.

Opportunities and limits of lunar gravitational-wave detection.

A new era of lunar exploration has begun with participation of all major space agencies. This activity brings opportunities for revolutionary science experiments and observatories on the Moon. The idea of a lunar gravitational-wave detector was already proposed during the Apollo programme. The key characteristic of the Moon is that it is seismically extremely quiet. It was also pointed out that the permanently shadowed regions at the lunar poles provide ideal conditions for gravitational-wave detection. In recent years, three different detector concepts were proposed with varying levels of technological complexity and science potential. In this paper, we confront the three concepts in terms of their observational capabilities based on a first more detailed modelling of instrumental noise. We identify important technological challenges and potential show-stoppers. This article is part of a discussion meeting issue 'Astronomy from the Moon: the next decades (part 2)'.

Seismic Background Limitation of Lunar Gravitational-Wave Detectors.

New concepts were recently proposed for gravitational-wave (GW) detectors on the Moon. These include laser-interferometric detectors, proposed as free-range or optical-fiber interferometers, and inertial acceleration sensors. Some of them exploit the response of the Moon to GWs, others follow the design of current laser-interferometric GW detectors, which directly measure the gravitational strain with suspended optics. All of these ideas emerged since the Moon offers an extremely quiet geophysical environment compared to Earth, but at the same time, one must realize that even the quiet lunar environment sets limits to the sensitivity of lunar GW detectors. In this Letter, we compare the proposed mission concepts in terms of their response to GWs and evaluate how they are affected by the lunar seismic background. We discuss available mitigation strategies. From these analyses, we infer the prime observation band of each detector concept.

Sensitivity and Specificity for the Detection of Clinical Mastitis by Automatic Milking Systems in Bavarian Dairy Herds.

In automatic milking systems (AMSs), the detection of clinical mastitis (CM) and the subsequent separation of abnormal milk should be reliably performed by commercial AMSs. Therefore, the objectives of this cross-sectional study were (1) to determine the sensitivity (SN) and specificity (SP) of CM detection of AMS by the four most common manufacturers in Bavarian dairy farms, and (2) to identify routinely collected cow data (AMS and monthly test day data of the regional Dairy Herd Improvement Association (DHIA)) that could improve the SN and SP of clinical mastitis detection. Bavarian dairy farms with AMS from the manufacturers DeLaval, GEA Farm Technologies, Lely, and Lemmer-Fullwood were recruited with the aim of sampling at least 40 cows with clinical mastitis per AMS manufacturer in addition to clinically healthy ones. During a single farm visit, cow-level milking information was first electronically extracted from each AMS and then all lactating cows examined for their udder health status in the barn. Clinical mastitis was defined as at least the presence of visibly abnormal milk. In addition, available DHIA test results from the previous six months were collected. None of the manufacturers provided a definition for clinical mastitis (i.e., visually abnormal milk), therefore, the SN and SP of AMS warning lists for udder health were assessed for each manufacturer individually, based on the clinical evaluation results. Generalized linear mixed models (GLMMs) with herd as random effect were used to determine the potential influence of routinely recorded parameters on SN and SP. A total of 7411 cows on 114 farms were assessed; of these, 7096 cows could be matched to AMS data and were included in the analysis. The prevalence of clinical mastitis was 3.4% (239 cows). When considering the 95% confidence interval (95% CI), all but one manufacturer achieved the minimum SN limit of >80%: DeLaval (SN: 61.4% (95% CI: 49.0%−72.8%)), GEA (75.9% (62.4%−86.5%)), Lely (78.2% (67.4%−86.8%)), and Lemmer-Fullwood (67.6% (50.2%−82.0%)). However, none of the evaluated AMSs achieved the minimum SP limit of 99%: DeLaval (SP: 89.3% (95% CI: 87.7%−90.7%)), GEA (79.2% (77.1%−81.2%)), Lely (86.2% (84.6%−87.7%)), and Lemmer-Fullwood (92.2% (90.8%−93.5%)). All AMS manufacturers' robots showed an association of SP with cow classification based on somatic cell count (SCC) measurement from the last two DHIA test results: cows that were above the threshold of 100,000 cells/mL for subclinical mastitis on both test days had lower chances of being classified as healthy by the AMS compared to cows that were below the threshold. In conclusion, the detection of clinical mastitis cases was satisfactory across AMS manufacturers. However, the low SP will lead to unnecessarily discarded milk and increased workload to assess potentially false-positive mastitis cases. Based on the results of our study, farmers must evaluate all available data (test day data, AMS data, and daily assessment of their cows in the barn) to make decisions about individual cows and to ultimately ensure animal welfare, food quality, and the economic viability of their farm.

Site-selection criteria for the Einstein Telescope.

The Einstein Telescope (ET) is a proposed next-generation, underground gravitational-wave detector to be based in Europe. It will provide about an order of magnitude sensitivity increase with respect to the currently operating detectors and, also extend the observation band targeting frequencies as low as 3 Hz. One of the first decisions that needs to be made is about the future ET site following an in-depth site characterization. Site evaluation and selection is a complicated process, which takes into account science, financial, political, and socio-economic criteria. In this paper, we provide an overview of the site-selection criteria for ET, provide a formalism to evaluate the direct impact of environmental noise on ET sensitivity, and outline the necessary elements of a site-characterization campaign.

Squeezed vacuum states of light for gravitational wave detectors.

A century after Einstein's formulation of general relativity, the detectors of the Laser Interferometer Gravitational-wave Observatory (LIGO) made the first direct detection of gravitational waves. This historic achievement was the culmination of a world-wide effort and decades of instrument research. While sufficient for this monumental discovery, the current generation of gravitational-wave detectors represent the least sensitive devices necessary for the task; improved detectors will be required to fully exploit this new window on the Universe. In this paper, we review the application of squeezed vacuum states of light to gravitational-wave detectors as a way to reduce quantum noise, which currently limits their performance in much of the detection band.

Prompt gravity signal induced by the 2011 Tohoku-Oki earthquake.

Transient gravity changes are expected to occur at all distances during an earthquake rupture, even before the arrival of seismic waves. Here we report on the search of such a prompt gravity signal in data recorded by a superconducting gravimeter and broadband seismometers during the 2011 Mw 9.0 Tohoku-Oki earthquake. During the earthquake rupture, a signal exceeding the background noise is observed with a statistical significance higher than 99% and an amplitude of a fraction of µGal, consistent in sign and order of magnitude with theoretical predictions from a first-order model. While prompt gravity signal detection with state-of-the-art gravimeters and seismometers is challenged by background seismic noise, its robust detection with gravity gradiometers under development could open new directions in earthquake seismology, and overcome fundamental limitations of current earthquake early-warning systems imposed by the propagation speed of seismic waves.

Quantification of the effects of fur, fur color, and velocity on Time-Of-Flight technology in dairy production.

With increasing herd sizes, camera based monitoring solutions rise in importance. 3D cameras, for example Time-Of-Flight (TOF) cameras, measure depth information. These additional information (3D data) could be beneficial for monitoring in dairy production. In previous studies regarding TOF technology, only standing cows were recorded to avoid motion artifacts. Therefore, necessary conditions for a TOF camera application in dairy cows are examined in this study. For this purpose, two cow models with plaster and fur surface, respectively, were recorded at four controlled velocities to quantify the effects of movement, fur color, and fur. Comparison criteria concerning image usability, pixel-wise deviation, and precision in coordinate determination were defined. Fur and fur color showed large effects (η (2)=0.235 and η (2)=0.472, respectively), which became even more considerable when the models were moving. The velocity of recorded animals must therefore be controlled when using TOF cameras. As another main result, body parts which lie in the middle of the cow model's back can be determined neglecting the effect of velocity or fur. With this in mind, further studies may obtain sound results using TOF technology in dairy production.

Terrestrial Gravity Fluctuations.

Different forms of fluctuations of the terrestrial gravity field are observed by gravity experiments. For example, atmospheric pressure fluctuations generate a gravity-noise foreground in measurements with super-conducting gravimeters. Gravity changes caused by high-magnitude earthquakes have been detected with the satellite gravity experiment GRACE, and we expect high-frequency terrestrial gravity fluctuations produced by ambient seismic fields to limit the sensitivity of ground-based gravitational-wave (GW) detectors. Accordingly, terrestrial gravity fluctuations are considered noise and signal depending on the experiment. Here, we will focus on ground-based gravimetry. This field is rapidly progressing through the development of GW detectors. The technology is pushed to its current limits in the advanced generation of the LIGO and Virgo detectors, targeting gravity strain sensitivities better than 10-23 Hz-1/2 above a few tens of a Hz. Alternative designs for GW detectors evolving from traditional gravity gradiometers such as torsion bars, atom interferometers, and superconducting gradiometers are currently being developed to extend the detection band to frequencies below 1 Hz. The goal of this article is to provide the analytical framework to describe terrestrial gravity perturbations in these experiments. Models of terrestrial gravity perturbations related to seismic fields, atmospheric disturbances, and vibrating, rotating or moving objects, are derived and analyzed. The models are then used to evaluate passive and active gravity noise mitigation strategies in GW detectors, or alternatively, to describe their potential use in geophysics. The article reviews the current state of the field, and also presents new analyses especially with respect to the impact of seismic scattering on gravity perturbations, active gravity noise cancellation, and time-domain models of gravity perturbations from atmospheric and seismic point sources. Our understanding of terrestrial gravity fluctuations will have great impact on the future development of GW detectors and high-precision gravimetry in general, and many open questions need to be answered still as emphasized in this article.

Upper limit on a stochastic background of gravitational waves from seismic measurements in the range 0.05-1 Hz.

In this Letter, we present an upper limit of ΩGW<1.2×108 on an isotropic stochastic gravitational-wave (GW) background integrated over a year in the frequency range 0.05-1 Hz, which improves current upper limits from high-precision laboratory experiments by about 9 orders of magnitude. The limit is obtained using the response of Earth itself to GWs via a free-surface effect described more than 40 years ago by Dyson. The response was measured by a global network of broadband seismometers selected to maximize the sensitivity.

Feasibility of automated body trait determination using the SR4K time-of-flight camera in cow barns.

As herd sizes have increased in the last decades, computerized monitoring solutions, which provide fast, objective and accurate evaluations of the herd status, gain more and more importance. This study analyzes the feasibility of a Time-of-Flight-camera-based system for gathering body traits in dairy cows for use under cow barn conditions. Recording, determination of body condition score on a 5 point scale by visual and manual inspection, and measuring the backfat thickness with ultrasound took place from July 2011 to May 2012 at the dairy research farm Karkendamm of the Institute of Animal Breeding and Husbandry, Christian-Albrechts-University Kiel (Germany) and between August 2010 and July 2012 at the Institute for Agricultural Engineering and Animal Husbandry of Bavarian State Research Center for Agriculture in Grub (Germany). The two breeds Holstein Friesian cows (Karkendamm) and Fleckvieh (Grub) were considered in this study. Software for recording, image sorting and evaluation, determining the body parts needed, and extracting traits from the images was written and assembled to an automated system. Sorting the images and finding ischeal tuberosities, base of the tail, and dishes of the rump, backbone, and hips had error rates of 0.2%, 1.5%, 0.1%, and 2.6%, respectively. 13 traits were extracted and compared to backfat thickness and body condition score as well as between breeds. All traits depend significantly on the animal and showed very large effect sizes. Coefficients of determination restricted to individual animals were reaching up to 0.89. The precision in measuring the traits and gathering backfat thickness was comparable. Results indicated that the application of Time-Of-Flight in determination of body traits is feasible.

Large-angle scattered light measurements for quantum-noise filter cavity design studies.

Optical loss from scattered light could limit the performance of quantum-noise filter cavities being considered for an upgrade to the Advanced Laser Interferometer Gravitational Wave Observatory (LIGO) gravitational-wave detectors. This paper describes imaging scatterometer measurements of the large-angle scattered light from two high-quality sample optics, a high reflector and a beamsplitter. These optics are each superpolished fused silica substrates with silica:tantala dielectric coatings. They represent the current state-of-the art optical technology for use in filter cavities. We present angle-resolved scatter values and integrate these to estimate the total scatter over the measured angles. We find that the total integrated light scattered into larger angles can be as small as 4 ppm.

[Stonefish stings: difficult analgesia and notable risk of complications]. / Piqûres par poisson-pierre: une antalgie difficile, un risque notable de complications.

INTRODUCTION: Marine activities and water sports in tropical countries entail some dangers. In our emergency department, stonefish (Synancae verrucosa) stings are second only to those by sea urchins among the 400 consultations a year for wounds by marine animals. METHOD: We retrospectively collected data for all emergency department visits for stonefish stings over a 5-year period from 2001 through 2005. RESULTS: The study included 57 patients (42 men; mean age 31.2+/-15.9 years, range 3-63 years) at 61 consultations. The reason for the emergency department visit was pain, often described as intense. Injuries occurred to the foot in 79% of cases and the hand in 21%. Local signs included a wound (100%), edema (74%), local inflammation (21%), bruising (23%), necrosis (19%), and, in one patient, cellulitis. Pain was reported in 95% of cases. Local care consisted of immersing the stung area in hot water (79%) or in situ lidocaine injection (16%). Analgesics were administered in 75% of the cases, including morphine (54%) and anti-inflammatory drugs in 47%. Other analgesic techniques included ketamine (3.5%), nitrous oxide (3.5%), and local or regional anesthesia (3.5%); 29% of patients received antibiotics. Patients requiring admission (46%) differed from those who did not by a need for more intense analgesia and by greater wound inflammation and necrosis. Three patients required surgery and three others, hyperbaric oxygen therapy. CONCLUSION: Stonefish stings present the risk of local complications. Analgesia is also a major concern for emergency physicians and prophylactic antibiotics must be considered.

Optical transfer functions of Kerr nonlinear cavities and interferometers.

We present the optical transfer functions for third-order nonlinear cavities that involve an optical carrier frequency and its modulation sideband fields. Our approach is based on linearized transformations and provides a convenient tool to calculate squeezed light sources as well as complex interferometer topologies, containing subsystems that involve intensity dependent phase shifts, i.e., optical Kerr media. As the result we present the noise spectral density of a Michelson interferometer with Kerr nonlinear arm cavities and resonant sideband extraction and find that quantum noise can be squeezed by arbitrary amounts even outside the cavity linewidth. Such a system might apply for future gravitational wave detectors or simply for a continuous wave source of squeezed states.