ABSTRACT
Three children with severe combined immunodeficiency have been isolated for 19-22 months. Two of the children have been placed into the isolation system directly after delivery; on child entered the isolation system at the age of 5 months. The influence of this situation on the psychic development of the children was studied by the means of direct observation as well as by psychometric test methods. An additional child which has been isolated between the age of 6 and 32 months was retested at the age of 4 and 6 years. The reported observation which include those of the parents and the team allow the conclusion, that a normal development is possible under these extreme conditions, when an optimal clinical and psychological support is maintained.
Subject(s)
Child Development , Patient Isolation , Child, Preschool , Female , Humans , Immunologic Deficiency Syndromes/therapy , Infant , Male , Mother-Child Relations , Psychometrics , Time FactorsABSTRACT
The current state of knowledge about osteogenesis imperfecta (O. i.) is reported. According to the course of the disease and the time of onset of first sym8ptoms two types of O. i may be recognized: O. i congenita (O. i. c.) and tarda (O. i. t.). O. i. c. is associated with a more severe course which may lead to extreme skeletal deformities. O. i. t. is characterized by a much milder course. It may exist almost unrecognized. Recent biochemical investigations of collagen revealed that in O. i. quantitative and qualitative abnormalities exist in the synthesis of collagen. Abnormally synthesized collagen is produced in total amounts less than normal. This fact leeds to changes of the physical properties of the connective tissue in cases of O. i. The letest attemp to treat O. i. is the application of calcitonin. This is expected to improve the mineralisation of the skeleton and to decrease the fragility of bones. So far, only reports about shortterm follow-ups during this treatment have been reported. Therefore, a conclusive statement about the validity of therapy with calcitonin can as yet not be given.
Subject(s)
Osteogenesis Imperfecta , Adolescent , Age Factors , Calcitonin/therapeutic use , Child , Child, Preschool , Collagen/biosynthesis , Humans , Infant , Osteogenesis Imperfecta/diagnosis , Osteogenesis Imperfecta/drug therapy , Osteogenesis Imperfecta/etiology , Time FactorsABSTRACT
Erythema neonatorum is the most common exanthematous eruption in neonates, which is always associated with an eosinophilic infiltration of the skin. Erythema neonatorum can be present at birth. It is of great importance in the differential diagnosis of pustular eruptions in newborns due to virus or bacteria, of miliaria pustulosa, and of incontinentia pigmenti.
Subject(s)
Erythema/diagnosis , Infant, Newborn, Diseases/diagnosis , Chickenpox/diagnosis , Diagnosis, Differential , Erythema/congenital , Erythema/pathology , Exanthema/diagnosis , Female , Herpes Simplex/diagnosis , Humans , Impetigo/diagnosis , Infant, Newborn , Infant, Newborn, Diseases/pathology , Male , Skin/pathology , Skin Diseases, Vesiculobullous/diagnosisABSTRACT
Three cases of congenital selective malabsorption of vitamin B12 (Imerslund-Grasbeck syndrome) are presented. Pathophysiological aspected and clinical symptoms of this disease are discussed together with other megaloblastic anaemias in childhood caused by vitamin B12 deficiency.
