1.
Chem Commun (Camb)
; 59(47): 7240-7242, 2023 Jun 08.
Article
in English
| MEDLINE
| ID: mdl-37222285
ABSTRACT
We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.