1.
Bioorg Med Chem Lett
; 24(4): 1148-53, 2014 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-24461295
ABSTRACT
A collection of αIIbß3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure-activity relationships, binding modality, and pharmacokinetic and pharmacodynamic profiles highlight the potential of these small molecule ion displacement ligands as attractive candidates for clinical development.