Search | VHL Regional Portal

Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.

Merriman, Gregory H; Ma, Liang; Shum, Patrick; McGarry, Daniel; Volz, Frank; Sabol, Jeffrey S; Gross, Alexandre; Zhao, Zhicheng; Rampe, David; Wang, Lin; Wirtz-Brugger, Friederike; Harris, Bruce A; Macdonald, Douglas.

Bioorg Med Chem Lett ; 15(2): 435-8, 2005 Jan 17.

Article in English | MEDLINE | ID: mdl-15603968

ABSTRACT

A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described.

Subject(s)

Hydrocarbons, Aromatic/chemistry , Imidazoles/pharmacology , Purinergic P2 Receptor Antagonists , Animals , Cell Line , Cricetinae , Imidazoles/chemical synthesis , Imidazolines/chemical synthesis , Imidazolines/pharmacology , Inhibitory Concentration 50 , Receptors, Purinergic P2X7 , Structure-Activity Relationship

Overview of the Alliance for Cellular Signaling.

Gilman, Alfred G; Simon, Melvin I; Bourne, Henry R; Harris, Bruce A; Long, Rochelle; Ross, Elliott M; Stull, James T; Taussig, Ronald; Bourne, Henry R; Arkin, Adam P; Cobb, Melanie H; Cyster, Jason G; Devreotes, Peter N; Ferrell, James E; Fruman, David; Gold, Michael; Weiss, Arthur; Stull, James T; Berridge, Michael J; Cantley, Lewis C; Catterall, William A; Coughlin, Shaun R; Olson, Eric N; Smith, Temple F; Brugge, Joan S; Botstein, David; Dixon, Jack E; Hunter, Tony; Lefkowitz, Robert J; Pawson, Anthony J; Sternberg, Paul W; Varmus, Harold; Subramaniam, Shankar; Sinkovits, Robert S; Li, Joshua; Mock, Dennis; Ning, Yuhong; Saunders, Brian; Sternweis, Paul C; Hilgemann, Donald; Scheuermann, Richard H; DeCamp, Dianne; Hsueh, Robert; Lin, Keng-Mean; Ni, Yan; Seaman, William E; Simpson, Paul C; O'Connell, Timothy D; Roach, Tamara; Simon, Melvin I.

Nature ; 420(6916): 703-6, 2002 Dec 12.

Article in English | MEDLINE | ID: mdl-12478301

ABSTRACT

The Alliance for Cellular Signaling is a large-scale collaboration designed to answer global questions about signalling networks. Pathways will be studied intensively in two cells--B lymphocytes (the cells of the immune system) and cardiac myocytes--to facilitate quantitative modelling. One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community.

Subject(s)

B-Lymphocytes/physiology , Myocytes, Cardiac/physiology , Research Design , Research Personnel/organization & administration , Research/organization & administration , Signal Transduction , B-Lymphocytes/cytology , Cooperative Behavior , Databases, Factual , International Cooperation , Internet , Ligands , Models, Biological , Myocytes, Cardiac/cytology , United States , Workforce

ABSTRACT

Subject(s)

ABSTRACT

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL