ABSTRACT
OBJECTIVES: To describe the social networks that diffuse knowledge, attitudes and behaviours relating to different domains of practice within teams of trainee doctors in an acute hospital medical setting. The domains examined were 'clinical-technical', 'patient centredness' and 'organisation of work'. DESIGN: Sequential mixed methods: (i) sociocentric survey of trainee consisting of questions about which colleagues are emulated or looked to for advice, with construction of social network maps, followed by (ii) semi-structured interviews regarding peer-to-peer influence, analysed using a grounded theory approach. The study took place over 24 months. SETTING: An acute medical admissions unit, which receives admissions from the emergency department and primary care, in a National Health Service England teaching hospital. PARTICIPANTS: Trainee medical doctors working in five consecutive rotational teams. Surveys were done by 39 trainee doctors; then 15 different participants from a maximal diversity sample were interviewed. RESULTS: Clinical-technical behaviours spread in a dense network with rich horizontal peer-to-peer connections. Patient-centred behaviours spread in a sparse network. Approaches to non-patient facing work are seldom copied from colleagues. Highly influential individuals for clinical technical memes were identified; high influencers were not identified for the other domains. CONCLUSION: Information and influence relating to different aspects of practice have different patterns of spread within teams of trainee doctors; highly influential individuals were important only for spread of clinical-technical practice. Influencers have particular characteristics, and this knowledge could guide leaders and teachers.
Subject(s)
Health Knowledge, Attitudes, Practice , Information Dissemination , Inservice Training , Patient-Centered Care , Physicians , Quality Improvement , Clinical Competence , England , Female , Grounded Theory , Humans , Interviews as Topic , Male , Physician-Patient Relations , Qualitative Research , Social NetworkingABSTRACT
BACKGROUND: Swallowing function in individuals with Parkinson's disease (PD) can be negatively affected by dopaminergic medication with associated inhibition of brainstem reflexes. Three different "swallowing-safety" profiles of PD patients were previously observed, classified according to swallowing safety on and off levodopa. METHODS: Here, we investigated the effects of l-dopa on pulmonary function tests (PFTs) on 26 individuals with PD from the three different swallowing-safety profiles. PFTs results were compared to predicted values and direct comparisons between the groups with or without dysphagia were performed with nonparametric statistical tests (i.e., Kruskal-Wallis). RESULTS: A short (12-hour) withdrawal from l-dopa did not result in any significant changes in PFTs, and no differences on PFTs results were observed between the different dysphagic groups the on and off l-dopa state. No correlation was observed between the PFTs results with swallowing safety profiles of PD patients. CONCLUSIONS: Although deglutition seems to be at least partially affected by dopaminergic repletion, dopaminergic mechanisms do not seem to be responsible for PD patients' performance in PFTs.
ABSTRACT
We have previously shown that labelled water positron emission tomography (H2(15)O PET) can be used to identify regional cerebral blood flow (rCBF) changes in the human brain during volitional swallowing. (18F) fluorodeoxyglucose (FDG PET), by comparison, uses a glucose analogue to quantitatively measure regional cerebral glucose metabolism (rCMRglc) rather than rCBF. The main advantage of FDG PET is improved spatial resolution, and because of its pharmacodynamic properties, activation can be performed external to the scanner, allowing subjects to assume more physiologic positions. We therefore conducted a study of the brain's metabolic response while swallowing in the erect seated position, using FDG PET. Eight healthy male volunteers were studied with a randomised 2 scan paradigm of rest or water swallowing at 20-second intervals for 30 minutes. Data were analysed with SPM99 using multisubject conditions and covariates design. During swallowing, analysis identified increased rCMRglc (P<0.01) in the following areas: left sensorimotor cortex, cerebellum, thalamus, precuneus, anterior insula, left and right lateral postcentral gyrus, and left and right occipital cortex. Decreased rCMRglc were also seen in the right premotor cortex, right and left sensory and motor association cortices, left posterior insula and left cerebellum. Thus, FDG PET can be applied to measure the brain metabolic activity associated with volitional swallowing and has the advantage of normal task engagement. This has implications for future activation studies in patients, especially those suffering swallowing problems after brain injury.
