Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Am Acad Dermatol ; 75(6): 1176-1186.e4, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27502312

ABSTRACT

BACKGROUND: Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas. OBJECTIVE: We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate the IMS and histopathological diagnoses with clinical behavior. METHODS: We conducted a retrospective collaborative study involving centers from 11 countries and 11 US institutions analyzing 102 ASNs by IMS. Patients were divided into clinical groups 1 to 4 representing best to worst clinical behavior. The association among IMS findings, histopathological diagnoses, and clinical groups was assessed. RESULTS: There was a strong association between a diagnosis of Spitzoid melanoma by IMS and lesions categorized as clinical groups 2, 3, and 4 (recurrence of disease, metastases, or death) compared with clinical group 1 (no recurrence or metastasis beyond a sentinel node) (P < .0001). Older age and greater tumor thickness were strongly associated with poorer outcome (P = .01). CONCLUSIONS: IMS diagnosis of ASN better predicted clinical outcome than histopathology. Diagnosis of Spitzoid melanoma by IMS was strongly associated with aggressive clinical behavior. IMS analysis using a proteomic signature may improve the diagnosis and prediction of outcome/risk stratification for patients with ASN.


Subject(s)
Mass Spectrometry , Melanoma/diagnostic imaging , Melanoma/secondary , Neoplasm Recurrence, Local/diagnostic imaging , Neoplasm Recurrence, Local/pathology , Nevus, Epithelioid and Spindle Cell/diagnostic imaging , Nevus, Epithelioid and Spindle Cell/pathology , Skin Neoplasms/diagnostic imaging , Skin Neoplasms/pathology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Child , Child, Preschool , Diagnosis, Differential , Female , Humans , Lymphatic Metastasis , Male , Melanoma/chemistry , Middle Aged , Neoplasm Recurrence, Local/chemistry , Nevus, Epithelioid and Spindle Cell/chemistry , Proteins/analysis , Retrospective Studies , Risk Assessment , Sentinel Lymph Node Biopsy , Skin Neoplasms/chemistry , Treatment Outcome , Tumor Burden , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...