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1.
Science ; 362(6419)2018 12 07.
Article in English | MEDLINE | ID: mdl-30409807

ABSTRACT

Studies of the peopling of the Americas have focused on the timing and number of initial migrations. Less attention has been paid to the subsequent spread of people within the Americas. We sequenced 15 ancient human genomes spanning from Alaska to Patagonia; six are ≥10,000 years old (up to ~18× coverage). All are most closely related to Native Americans, including those from an Ancient Beringian individual and two morphologically distinct "Paleoamericans." We found evidence of rapid dispersal and early diversification that included previously unknown groups as people moved south. This resulted in multiple independent, geographically uneven migrations, including one that provides clues of a Late Pleistocene Australasian genetic signal, as well as a later Mesoamerican-related expansion. These led to complex and dynamic population histories from North to South America.


Subject(s)
Genome, Human , Human Migration , Indians, North American/genetics , Datasets as Topic , Asia, Eastern/ethnology , Genomics , Humans , North America , Polymorphism, Single Nucleotide , Population Dynamics , Siberia/ethnology , South America
2.
Hum Biol ; 88(4): 251-263, 2016 Oct.
Article in English | MEDLINE | ID: mdl-28826319

ABSTRACT

This study presents genetic data for nine Native American populations from northern North America. Analyses of genetic variation focus on the Pacific Northwest (PNW). Using mitochondrial, Y chromosomal, and autosomal DNA variants, we aimed to more closely address the relationships of geography and language with present genetic diversity among the regional PNW Native American populations. Patterns of genetic diversity exhibited by the three genetic systems were consistent with our hypotheses: genetic variation was more strongly explained by geographic proximity than by linguistic structure. Our findings were corroborated through a variety on analytic approaches, with the unrooted trees for the three genetic systems consistently separating inland from coastal PNW populations. Furthermore, analyses of molecular variance support the trends exhibited by the unrooted trees, with geographic partitioning of PNW populations (FCT = 19.43%, p = 0.010 ± 0.009) accounting for over twice as much of the observed genetic variation as linguistic partitioning of the same populations (FCT = 9.15%, p = 0.193 ± 0.013). These findings demonstrate a consensus with previous PNW population studies examining the relationships of genome-wide variation, mitochondrial haplogroup frequencies, and skeletal morphology with geography and language.


Subject(s)
Genetics, Population , Indians, North American/genetics , Phylogeny , Chromosomes, Human, Y , Cluster Analysis , DNA, Mitochondrial/genetics , Emigration and Immigration , Genetic Variation , Geography , Humans , Linguistics , Northwestern United States , Sequence Analysis, DNA
3.
PLoS Genet ; 10(8): e1004530, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25122539

ABSTRACT

The initial contact of European populations with indigenous populations of the Americas produced diverse admixture processes across North, Central, and South America. Recent studies have examined the genetic structure of indigenous populations of Latin America and the Caribbean and their admixed descendants, reporting on the genomic impact of the history of admixture with colonizing populations of European and African ancestry. However, relatively little genomic research has been conducted on admixture in indigenous North American populations. In this study, we analyze genomic data at 475,109 single-nucleotide polymorphisms sampled in indigenous peoples of the Pacific Northwest in British Columbia and Southeast Alaska, populations with a well-documented history of contact with European and Asian traders, fishermen, and contract laborers. We find that the indigenous populations of the Pacific Northwest have higher gene diversity than Latin American indigenous populations. Among the Pacific Northwest populations, interior groups provide more evidence for East Asian admixture, whereas coastal groups have higher levels of European admixture. In contrast with many Latin American indigenous populations, the variance of admixture is high in each of the Pacific Northwest indigenous populations, as expected for recent and ongoing admixture processes. The results reveal some similarities but notable differences between admixture patterns in the Pacific Northwest and those in Latin America, contributing to a more detailed understanding of the genomic consequences of European colonization events throughout the Americas.


Subject(s)
Genetics, Population , Genomics , Haplotypes/genetics , Asian People/genetics , DNA, Mitochondrial/genetics , Humans , North America , Polymorphism, Single Nucleotide , White People/genetics
4.
Am J Phys Anthropol ; 141(3): 494-7, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20027611

ABSTRACT

Mitochondrial DNA analysis of 31 unrelated Shuswap speakers from a previously poorly sampled region of North America revealed two individuals with haplogroups rarely found in the Americas, C4c and C1d. Comparison of the complete genomes of the two individuals with others found in the literature confirms that C4c is a founding haplotype and gives insight into the evolution of the C1d haplotype. This study demonstrates the importance of collecting and analyzing data from Native North Americans when addressing hypotheses about the peopling of the Americas.


Subject(s)
DNA, Mitochondrial/genetics , Founder Effect , Genome, Human , Indians, North American/genetics , Mitochondria/genetics , DNA/genetics , DNA/isolation & purification , Gene Amplification , Haplotypes/genetics , Humans , Mutation , North America , Phylogeny , Saliva/chemistry
5.
Bull. W.H.O. (Print) ; 18(5-6): 819-832, 1958.
Article in English | WHO IRIS | ID: who-265507
6.
Bull. W.H.O. (Print) ; 18(5-6): 1037-1047, 1958.
Article in English | WHO IRIS | ID: who-265496
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