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1.
Anal Methods ; 16(16): 2614, 2024 Apr 25.
Article in English | MEDLINE | ID: mdl-38600853

ABSTRACT

Correction for 'An impedimetric sensor based on molecularly imprinted nanoparticles for the determination of trypsin in artificial matrices - towards point-of-care diagnostics' by Sabrina Di Masi et al., Anal. Methods, 2024, 16, 742-750, https://doi.org/10.1039/D3AY01762A.

2.
Anal Methods ; 16(5): 742-750, 2024 02 01.
Article in English | MEDLINE | ID: mdl-38224108

ABSTRACT

A high-performance impedimetric sensing platform was designed to detect proteins by employing molecularly imprinted polymeric nanoparticles (nanoMIPs) as selective receptors. This was achieved via the combination of the nanoMIPs with a self-assembled thioctic acid (SAM-TA) monolayer onto screen-printed gold electrodes, providing stable covalent attachment of the selective binder to the transducer. Taguchi design has been modelled to achieve the optimal level of sensor fabrication parameters and to maximise the immobilisation of nanoMIPs and their response (e.g. the response of imprinted polymers compared with the non-imprinted control). The developed sensor was tested towards a range of concentrations of trypsin dissolved in ammonium acetate (pH = 6) and showed promising applicability in artificial saliva, with a recovery percentage between 103 and 107%.


Subject(s)
Biosensing Techniques , Molecular Imprinting , Nanoparticles , Trypsin , Polymers , Point-of-Care Testing
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