ABSTRACT
BACKGROUND: Bariatric surgery is the most effective treatment choice for severe obesity. Recent literature indicates that FK506-binding protein 51 (FKBP51) could play a role in energy homeostasis, influencing adipogenesis and weight. OBJECTIVE: To evaluate if the presence of the T allele of the FKBP5 SNP rs1360780, associated with increased FKBP51 expression, could influence weight loss after bariatric surgery. SETTING: Hospital de Clínicas de Porto Alegre, Brazil. METHODS: Forty-two patients awaiting bariatric surgery were included, and the presence of the FKBP5 rs1360780 polymorphism was evaluated. During the postoperative period, a 26-month follow-up of weight loss was performed (n = 42, 36, 35, 35, and 30, from the first to fifth postoperative evaluation, respectively; loss to follow-up: 28.6%). RESULTS: Carriers of the T allele presented significantly lower weight loss compared with patients with the C/C genotype after the 12th to 14th month follow-up period. Differences in weight loss between genotypes ranged from 14.2% to 19.9% of excess weight loss (P = .045 and .004, respectively) and from 7.6% to 9.0% of total weight loss (P = .002 for both comparisons). Furthermore, carriers of the T allele also presented an earlier cessation of weight loss after surgery. CONCLUSION: The presence of the T allele of the FKBP5 SNP rs1360780 was associated with weight loss after bariatric surgery. Bariatric surgery can interact with genes involved in metabolic regulation, leading to different weight loss outcomes.
Subject(s)
Gastric Bypass , Polymorphism, Single Nucleotide/genetics , Tacrolimus Binding Proteins/genetics , Weight Loss/genetics , Adolescent , Adult , Aged , Alleles , Female , Genotype , Humans , Male , Middle Aged , Obesity, Morbid/genetics , Obesity, Morbid/surgery , Prospective Studies , Young AdultABSTRACT
O debate sobre a transmissão do psiquismo entre gerações, embora presentedesde o início na obra de Freud, teve nos últimos anos um novo impulso napsicanálise, com vários trabalhos dedicados à articulação da realidade psíquicado sujeito singular com a realidade psíquica do grupo. O estudo dessesfenômenos pode enriquecer a compreensão do sofrimento psíquico, e oobjetivo deste trabalho é realizar uma revisão teórica sobre o tema da transmissãodo psiquismo entre as gerações, nas modalidades intergeracional etransgeracional, exemplificando-se com um caso clínico.(AU)
The debate about psychic transmission between generations has been present,in the work of Freud, since the beginning of psychoanalysis. But there hasbeen a renewal of interest about this subject in the last years, and many articleshave been dedicated to the understanding of the relationship between thepsychic reality of the singular person and that of his group. The study of thisphenomenon can enrich our comprehension of psychic suffering. So, theobjective of this work is to proceed a revision of the literature about this topic on its two modalities, intergenerational and transgenerational transmission.A clinical report is included as an illustration.
Subject(s)
Adult , Aged , Identification, Psychological , PsychoanalysisABSTRACT
O debate sobre a transmissão do psiquismo entre gerações, embora presentedesde o início na obra de Freud, teve nos últimos anos um novo impulso napsicanálise, com vários trabalhos dedicados à articulação da realidade psíquicado sujeito singular com a realidade psíquica do grupo. O estudo dessesfenômenos pode enriquecer a compreensão do sofrimento psíquico, e oobjetivo deste trabalho é realizar uma revisão teórica sobre o tema da transmissãodo psiquismo entre as gerações, nas modalidades intergeracional etransgeracional, exemplificando-se com um caso clínico.
The debate about psychic transmission between generations has been present,in the work of Freud, since the beginning of psychoanalysis. But there hasbeen a renewal of interest about this subject in the last years, and many articleshave been dedicated to the understanding of the relationship between thepsychic reality of the singular person and that of his group. The study of thisphenomenon can enrich our comprehension of psychic suffering. So, theobjective of this work is to proceed a revision of the literature about this topic on its two modalities, intergenerational and transgenerational transmission.A clinical report is included as an illustration.
