Myeloid-derived suppressor cells and plasmacytoid dendritic cells are associated with oncogenesis of oral squamous cell carcinoma.

Myeloid-derived suppressor cells (MDSCs) help establish the tumor microenvironment by suppressing T-cell response in tumor-bearing hosts. Plasmacytoid dendritic cells (pDCs) activate antigen-specific T cells, thereby, maximizing their antitumor effects. IDO1 is associated with both MDSCs and pDCs and plays a major role in the formation of the tumor-mediated immunosuppressive environment. We utilized immunohistochemistry to examine the involvement of IDO1 in oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs, precancerous lesions). We examined the expression of MDSC markers, CD11b and CD33, as well as pDC markers, CD303 and IDO1, in 60 OSCC and 45 precancerous lesion specimens and analyzed their association with clinicopathological parameters. Expression of these biomarkers identifying MDSCs and pDCs was high in precancerous lesions in patients with severe dysplasia and OSCC. While detecting pDCs, high CD303 and IDO1 expression levels were frequently observed in moderately or poorly differentiated OSCCs. CD11b, CD33, and CD303 levels were significantly correlated with the mode of invasion; CD33 was correlated with OSCC invasion depth while the other three markers tended to be highly expressed in superficial cancer cases showing microinvasion. Expression levels of all four biomarkers were significantly associated with the cancerization of OPMDs to OSCCs. We show, for the first time, that the infiltration of MDSCs and pDCs is significantly associated with progression of premalignant lesions to OSCC. This suggests that these cells may act as prognostic biomarkers for premalignant lesion progression and that immunotherapeutic approaches that control each of these immunosuppressive cells may protect against progression to malignancy.

"Cancer and Acupuncture & Moxibustion"-The Effective Indications and the Limitations of Acupuncture Treatments as Primary and Secondary Preventions (Treating Patient before Disease Arises), Treatments, Palliative Cares of Cancer- / 全日本鍼灸学会雑誌

In recent years, we have been told that the western medicine has developed the techniques of treatments on cancer, but the truth is that very few practical accomplishments has been made, while death rate from cancer has been steadily increasing. Although acupuncture has been thought to be ineffective in the treatments of cancer, nowadays we find some reports concerning its effectiveness in palliative cares, improvements of quality of life (QOL) and cancer regressions. Thus, this symposium was planned to investigate this theme. There were reports from appointed speakers on the acupuncturists' feelings of swung back and forth between joy and despair when treating patients with cancer, the experiences in treating her parents who died of lung cancer, and the patients who failed or rejected to be treated in western medicine but successfully treated using acupuncture eventually.<BR>A panelist who practices acupuncture treatments in a hospital reported the effectiveness and indications on combined application of acupuncture and standard treatments for the patients in the terminal stage of cancer. He also reported that no correlation had been found between effective rates and duration (frequency) of treatments neither between stages (duration) of disorders and efficacy. Furthermore, if the environment of acupuncture treatment is well organized, he mentioned that acupuncture can produce a good deal of effect even in patients with terminal stage. He also reported that acupuncture will be able to influence on the physiology in autonomic nervous system, leading to the hyperactivity of parasympathetic nerve.<BR>A panelist who practices his acupuncture treatments based on the theory of Professor Abo reported the effectiveness of acupuncture in improving QOL and in prolonging one's life. He showed an actual situation of the patient with scirrhous carcinoma who had prolonged his life for a long period using acupuncture treatment. He also demonstrated that radiotherapy, one of the three major medical treatments for cancer, will deprive the resistance of the patients.<BR>A panelist who advocates salutogenesis demonstrated the possibility of the direct effectiveness of acupuncture treatment on cancer because acupuncture has significant effects in alleviating pains and enhancing the power of restoring human energy in patients with cancer. He mentioned the limitation of the treatments using “a theory of pathogenesis (modern medicine)” and the importance of the treatments using “a theory of salutogenesis (traditional medicine)”, and emphasized the necessity of acupuncture treatments as well as supplemental agents, and the importance of psychological approaches toward the mind of patients.<BR>In this symposium, the efficacy of acupuncture treatments as palliative cares was indicated. Although there are few convincing evidences, the efficacy of acupuncture treatments as one of treatment methods for cancer may be demonstrated. Further integrative researches on the efficacy of acupuncture in patients with cancer are needed.