ABSTRACT
PURPOSE: To compare the efficacy of bromfenac sodium ophthalmic solution (BF) and a steroidal solution (ST) administered prophylactically against cystoid macular oedema and anterior-chamber inflammation after phacoemulsification and intraocular lens implantation and to assess macular thickness changes using optical coherence tomography (OCT). METHODS: In this prospective study, 62 eyes of 62 patients were randomized to either the BF group (n=31) or the ST group (n =31). The average perifoveal thickness (AFT) was measured by OCT preoperatively, and 1 day and 1, 2, 4 and 6 weeks postoperatively. The best-corrected visual acuity, intraocular pressure and flare in the anterior chamber were recorded at each visit. The same method was used to compare patients with non-proliferative diabetic retinopathy (NPDR) in the BF (n = 16) and ST (n =11) groups. RESULTS: In the analysis of all patients, flare in the anterior chamber was significantly (p = 0.007) lower in the BF group 2 weeks postoperatively. In patients with NPDR, the anterior chamber flare values were significantly lower in the BF group at 4 weeks (p = 0.0009) and 6 weeks (p = 0.005). The AFT values were significantly lower in the BF group at 4 weeks (p < 0.0001) and 6 weeks (p < 0.0001). No adverse events occurred in either group. CONCLUSION: BF suppressed anterior chamber inflammation and increasing retinal thickening after cataract surgery in patients with NPDR.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Benzophenones/therapeutic use , Bromobenzenes/therapeutic use , Diabetic Retinopathy/complications , Macular Edema/prevention & control , Phacoemulsification , Postoperative Complications/prevention & control , Adult , Aged , Aged, 80 and over , Anterior Chamber/pathology , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Benzophenones/adverse effects , Bromobenzenes/adverse effects , Female , Glucocorticoids/adverse effects , Glucocorticoids/therapeutic use , Humans , Intraocular Pressure/physiology , Lens Implantation, Intraocular , Macular Edema/etiology , Macular Edema/physiopathology , Male , Middle Aged , Ophthalmic Solutions/adverse effects , Ophthalmic Solutions/therapeutic use , Prospective Studies , Tomography, Optical Coherence , Treatment Outcome , Uveitis, Anterior/drug therapy , Uveitis, Anterior/physiopathology , Visual Acuity/physiologySubject(s)
Diabetes Complications/complications , Fluorescein Angiography/methods , Kidney Diseases/complications , Kidney Diseases/pathology , Kidney Function Tests/methods , Adult , Aged , Aged, 80 and over , Chronic Disease , Female , Fluorescein Angiography/adverse effects , Humans , Kidney/metabolism , Kidney Function Tests/adverse effects , Male , Middle AgedABSTRACT
PURPOSE: To evaluate the blood flow velocity in the ophthalmic artery using color Doppler imaging in two patients who had diabetic retinopathy with amaurosis fugax caused by orthostatic hypotension. DESIGN: Interventional case reports. METHODS: A 40-year-old woman (Case 1) and a 65-year-old man (Case 2) had diabetic retinopathy and amaurosis fugax caused by orthostatic hypotension. We evaluated the blood flow velocity in the ophthalmic artery using color Doppler imaging in the two patients. SETTING: Department of Ophthalmology, Diabetes Center Tokyo Women's Medical University, Tokyo, Japan. RESULTS: For Case 1, the maximum systolic blood flow velocity in the ophthalmic artery (V max) was 10 cm/sec in the supine position. In a seated position, visual acuity was decreased from 20/20 to light perception as V max fell to 1 cm/sec. For Case 2, the V max was 14 cm/sec in the supine position, but it was too low to measure in a seated position. CONCLUSIONS: The decrease of V max by orthostatic hypotension may cause amaurosis fugax in patients with diabetic retinopathy.
