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Article in English | MEDLINE | ID: mdl-25559515

ABSTRACT

Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.


Subject(s)
Cytomegalovirus Retinitis/therapy , Immunotherapy, Adoptive , Phosphoproteins/immunology , T-Lymphocytes, Cytotoxic/immunology , Viral Matrix Proteins/immunology , Adult , Cytomegalovirus/isolation & purification , Cytotoxicity, Immunologic , Humans , Infusions, Intravenous , Male , Viral Load , Viremia/therapy
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