Role of Artificial Intelligence in PET/CT Imaging for Management of Lymphoma.

Our review shows that AI-based analysis of lymphoma whole-body FDG-PET/CT can inform all phases of clinical management including staging, prognostication, treatment planning, and treatment response evaluation. We highlight advancements in the role of neural networks for performing automated image segmentation to calculate PET-based imaging biomarkers such as the total metabolic tumor volume (TMTV). AI-based image segmentation methods are at levels where they can be semi-automatically implemented with minimal human inputs and nearing the level of a second-opinion radiologist. Advances in automated segmentation methods are particularly apparent in the discrimination of lymphomatous vs non-lymphomatous FDG-avid regions, which carries through to automated staging. Automated TMTV calculators, in addition to automated calculation of measures such as Dmax are informing robust models of progression-free survival which can then feed into improved treatment planning.

Trustworthy Artificial Intelligence in Medical Imaging.

Trust in artificial intelligence (AI) by society and the development of trustworthy AI systems and ecosystems are critical for the progress and implementation of AI technology in medicine. With the growing use of AI in a variety of medical and imaging applications, it is more vital than ever to make these systems dependable and trustworthy. Fourteen core principles are considered in this article aiming to move the needle more closely to systems that are accurate, resilient, fair, explainable, safe, and transparent: toward trustworthy AI.

Applications of Artificial Intelligence in 18F-Sodium Fluoride Positron Emission Tomography/Computed Tomography:: Current State and Future Directions.

This review discusses the current state of artificial intelligence (AI) in 18F-NaF-PET/CT imaging and the potential applications to come in diagnosis, prognostication, and improvement of care in patients with bone diseases, with emphasis on the role of AI algorithms in CT bone segmentation, relying on their prevalence in medical imaging and utility in the extraction of spatial information in combined PET/CT studies.

Artificial Intelligence in Medical Imaging and its Impact on the Rare Disease Community: Threats, Challenges and Opportunities.

Almost 1 in 10 individuals can suffer from one of many rare diseases (RDs). The average time to diagnosis for an RD patient is as high as 7 years. Artificial intelligence (AI)-based positron emission tomography (PET), if implemented appropriately, has tremendous potential to advance the diagnosis of RDs. Patient advocacy groups must be active stakeholders in the AI ecosystem if we are to avoid potential issues related to the implementation of AI into health care. AI medical devices must not only be RD-aware at each stage of their conceptualization and life cycle but also should be trained on diverse and augmented datasets representative of the end-user population including RDs. Inability to do so leads to potential harm and unsustainable deployment of AI-based medical devices (AIMDs) into clinical practice.

Artificial Intelligence in Lymphoma PET Imaging:: A Scoping Review (Current Trends and Future Directions).

Malignant lymphomas are a family of heterogenous disorders caused by clonal proliferation of lymphocytes. 18F-FDG-PET has proven to provide essential information for accurate quantification of disease burden, treatment response evaluation, and prognostication. However, manual delineation of hypermetabolic lesions is often a time-consuming and impractical task. Applications of artificial intelligence (AI) may provide solutions to overcome this challenge. Beyond segmentation and detection of lesions, AI could enhance tumor characterization and heterogeneity quantification, as well as treatment response prediction and recurrence risk stratification. In this scoping review, we have systematically mapped and discussed the current applications of AI (such as detection, classification, segmentation as well as the prediction and prognostication) in lymphoma PET.

Artificial Intelligence and Positron Emission Tomography Imaging Workflow:: Technologists' Perspective.

Artificial intelligence (AI) can enhance the efficiency of medical imaging quality control and clinical documentation, provide clinical decision support, and increase image acquisition and processing quality. A clear understanding of the basic tenets of these technologies and their impact will enable nuclear medicine technologists to train for performing advanced imaging tasks. AI-enabled medical devices' anticipated role and impact on routine nuclear medicine workflow (scheduling, quality control, check-in, radiotracer injection, waiting room, image planning, image acquisition, image post-processing) is reviewed in this article. With the assistance of AI, newly compiled patient imaging data can be customized to encompass personalized risk assessments of patients' disease burden, along with the development of individualized treatment plans. Nuclear medicine technologists will continue to play a crucial role on the medical team, collaborating with patients and radiologists to improve each patient's imaging experience and supervising the performance of integrated AI applications.