ABSTRACT
Two patients had streptococcal myositis. Both patients developed extensive muscle necrosis and overwhelming sepsis after trivial skin trauma. Death occurred within 48 hours of hospital admission despite aggressive surgical and medical treatment. Review of the literature is included to highlight the fulminant nature of this unusual infection and to contrast streptococcal myositis with other soft-tissue streptococcal infections.
Subject(s)
Myositis/pathology , Streptococcal Infections/pathology , Adult , Arm , Autopsy , Female , Humans , Leg , Male , Middle Aged , Mouth Diseases/complications , Muscles/microbiology , Muscles/pathology , Myositis/etiology , Myositis/microbiology , Necrosis , Skin/injuries , Streptococcal Infections/etiology , Streptococcal Infections/microbiology , Streptococcus pyogenes/isolation & purification , Ulcer/complicationsSubject(s)
Ascorbic Acid/therapeutic use , Hypergammaglobulinemia/therapy , Immunoglobulin E , Transfer Factor/therapeutic use , Adult , Blood Bactericidal Activity , Cell Movement , Chemotaxis, Leukocyte , Granulocytes/immunology , Humans , Hypergammaglobulinemia/drug therapy , Lymphocyte Activation , Male , Rosette Formation , SyndromeABSTRACT
Actinomyces odontolyticus was isolated from a patient with a soft tissue mass in the malar region. The organism was identified on the basis of morphological, cultural, and biochemical characteristics. On histological examination, the tissue mass contained several granulomatous foci with small, basophilic staining areas resembling microscopic sulfur granules. This is believed to be the first reported case of actinomycosis due to A. odontolyticus.
Subject(s)
Actinomyces/isolation & purification , Actinomycosis, Cervicofacial/microbiology , Granuloma/microbiology , Actinomycosis, Cervicofacial/pathology , Cheek , Granuloma/pathology , Humans , Male , Middle AgedABSTRACT
Rational antimicrobial therapy depends on the identity of the causative organisms, the location of the infection, and the condition of the host. Selection of antimicrobial therapy is often started before identification of the causative organism is complete. Certain cultural and staining procedures must be instigated prior to therapy in order to isolate the causative organism. Knowledge of the host's physiologic state is necessary to minimize toxicities and/or failures of therapy. Knowledge of synergistic and antagonistic actions of some antimicrobial agents is necessary for optimal results.
