Larger lateral hinges increase the probability of Takeuchi type II and III fractures in high tibial osteotomy.

PURPOSE: Lateral hinge fractures are the main complications in the high tibial osteotomy to treat varus deformities. The aim of present study is to answer the question whether the lateral hinge length (H) has an effect on the type of fracture and required force during the opening in high tibia osteotomy. It was hypothesized in this comparative research that extending the hinge length increased opening force and probability of a type II and type III fractures. METHODS: A monoplanar medial open wedge osteotomy with different intact hinge lengths varying from 9 to 32 mm was performed in 20 ostrich bones. A biomechanical experiment using unidirectional tensile testing apparatus was performed to open the wedge, and the required force was increased until a 10 mm opening was reached; then, the presence of fracture in the lateral cortex and its direction were evaluated. Lateral hinge fracture type based on direction was classified as suggested by Takeuchi et al. RESULTS: Fracture that grows along the osteotomy line (type I) was observed in 4 samples with the mean hinge length (H) of 11 ± 1.54 mm. For seven bones with Takeuchi fracture type II, with downward crack propagation, the mean H was 16 ± 3.36 mm. For the mean H of 25 ± 6.53 mm, the crack propagated upward to the cutting path, displaying a Takeuchi type III fracture in seven samples. The statistical analysis showed that the fracture type significantly depends on the hinge length (P value < 0.05). Also, the mean opening force significantly increased with hinge lengthening (P value < 0.05). The peak forces at crack initiation were 41.8 ± 21.9, 115.2 ± 41.5, and 167 ± 135.3 N, respectively, for the fracture types I, II, and III samples. CONCLUSION: The lateral cortical hinge length was significantly associated with hinge fracture type. The experimental tests indicated that the hinge lengthening increases the risk of type II and III fractures, as classified by Takeuchi.

Effect of loading direction and anatomical location on the ultimate tensile stress, fracture toughness, and failure patterns of knee meniscus.

BACKGROUND: Rupture of the knee menisci is a common injury that can have implications for other conditions, such as osteoarthritis. The fracture toughness of soft tissue (Jc) is a mechanical property that characterizes its resistance to tear extension. To date, Jc of the meniscus has not been quantified. METHODS: Cyclic tensile tests were conducted on meniscus samples to determine Jc and explore its characteristics. Initially, the study investigated the impact of an initial notch on the ultimate tensile stress. This allowed for an understanding of how the presence of a notch affects its structural integrity. Subsequently, Jc was measured in both the radial and circumferential directions to assess its loading direction dependency. Furthermore, the study assessed the effect of anatomical location by comparing samples collected from the femoral and tibial layers. RESULTS: Defect tolerance of the meniscus is influenced by the loading direction. In the circumferential direction, the presence of an initial notch did not affect the ultimate stress, and no crack expansion was observed. In radial samples with a notch length of 40% or more of the total width, crack propagation occurred, leading to a decrease in the ultimate stress (p< 0.01). Additionally, Jc was found to be higher in the femoral layer compared to the tibial layer (p= 0.017). CONCLUSION: The study also examined the failure patterns of the meniscus to enhance our understanding of its pathology. These insights contribute to a better comprehension of meniscus injuries and can aid in the development of more effective treatment strategies.

Effect of temperature on dynamic compressive behavior of periodontal ligament.

Periodontal ligament (PDL) attaches tooth root to the surrounding bone. Its existence between tooth and jaw bone is of utmost importance due to its significant role in absorbing and distributing physiological and para-physiological loading. According to the previous studies, various mechanical tests have been performed to characterize the mechanical properties of the PDL; however, all of them have been done at room temperature. To the best of our knowledge, this is the first study in which the testing was performed at body temperature. The present research was planned to measure the dependency of PDL's viscoelastic behavior on temperature and frequency. Three different temperatures, including body and room temperature, were opted to perform the dynamic compressive tests of the bovine PDL. In addition, a Generalized Maxwell model (GMM) was presented based on empirical outcomes. At 37 °C, amounts of loss factor were found to be greater than those in 25 °C, which demonstrates that the viscous phase of the PDL in higher temperatures plays a critical role. Likewise, by raising the temperature from 25 °C to 37 °C, the model parameters show an enlargement in the viscous part and lessening in the elastic part. It was concluded that the PDL's viscosity in body temperature is much higher than that in room temperature. This model would be functional for a more accurate computational analysis of the PDL at the body temperature (37 °C) in various loading conditions such as orthodontic simulations, mastication, and impact.

Homogeneous material models can overestimate stresses in high tibial osteotomy: A finite element analysis.

Although widely used numerical models can assess the stability of lateral hinges in high tibial osteotomy (HTO) and may provide acceptable results in comparative studies, accurate stress prediction may not be possible due to simplified homogeneous models of the bone. The present study aimed to investigate the effect of a heterogeneous versus four homogeneous models on the results of stress and force. Each of the four homogenized FE models utilized the same elastic modulus of 16,700 MPa for the cortical while employing a single elastic modulus varying from 155 to 5000 MPa for the cancellous. In heterogeneous model, the modulus of each element was assigned using the bone density. It was found that stresses at the hinge in homogeneous models were higher than those in the heterogeneous model. The maximum principal stress (MPS) was 437 MPa for the heterogeneous model while that was 2179, 2351, 2581, and 2637 MPa for the homogeneous models with the elastic moduli of 155, 500, 2130, and 5000 MPa, respectively. Also, the opening force was 150 N for the heterogeneous model significantly lower than 649-1534 N range predicted for the homogeneous models. The use of a homogeneous model in the FE analysis of HTO overestimated the stresses and force. Thus, in addition to casting doubt on the use of a single modulus in the numerical analysis of HTO, Future HTO studies can use our results as a benchmark for comparison purposes and highlight the use of patient-specific bone density - elastic modulus relation in simulation.

Replacement of Destructive Pull-out Test with Modal Analysis in Primary Fixation Stability Assessment of Spinal Pedicle Screw.

Background: Pedicle screw fixation devices are the predominant stabilization systems adopted for a wide variety of spinal defects. Accordingly, both pedicle screw design and bone quality are known as the main parameters affecting the fixation strength as measured by the pull-out force and insertion torque. The pull-out test method, which is recommended by the standards of the American Society for Testing and Materials (ASTM), is destructive. A non-destructive test method was proposed to evaluate the mechanical stability of the pedicle screw using modal analysis. Natural frequency (ωn) extracted from the modal analysis was then correlated with peak pull-out force (PPF) and peak insertion torque (PIT). Methods: Cylindrical pedicle screws with a conical core were inserted into two different polyurethane (PU) foams with densities of 0.16 and 0.32 g/cm3. The PIT and PPF were measured according to the well-established ASTM-F543 standard at three different insertion depths of 10, 20, and 30 mm. Modal analysis was carried out through recording time response of an accelerometer attached to the head of the screw impacted by a shock hammer. The effect of the insertion depth and foam density on the insertion torque, natural frequency, and pull-out force were quantified. Results: The maximum values of ωn, PIT, and PPT were obtained at 2,186 Hz, 123.75 N.cm, and 981.50 N, respectively, when the screw was inserted into the high-density foam at the depth of 30 mm. The minimum values were estimated at 332 Hz, 16 N.cm, and 127 N, respectively, within the low-density PU at the depth of 10 mm. The higher value of ωn was originated from higher bone screw stability and thus more fixation strength. According to the regression analysis outcomes, the natural frequency (ωn) was linearly dependent on the PIT (ωn=14 PIT) and also on the PPF (ωn=1.7 PPF). Coefficients of variation as the results of the modal analysis were significantly less than those in conventional methods (i.e. pull-out and insertion torque). Conclusion: The modal analysis was found to be a reliable, repeatable, and non-destructive method, which could be considered a prospective alternative to the destructive pull-out test that is limited to the in-vitro application only. The modal analysis could be applied to assess the stability of implantable screws, such as orthopedic and spinal screws.

Effect of hinge length on the lateral cortex fracture in high tibia osteotomy: an XFEM study.

The main disadvantage of high tibial osteotomy (HTO) is the fracture of the lateral hinge during surgery. Therefore, the present study was designed to investigate the effect of different hinge lengths on the fracture type of the lateral hinge during the opening in HTO. For this purpose, extended finite element method (XFEM) was used to predict the crack initiation and growth in bone cortex in twelve models, each with different hinge lengths and medial start points. It was shown that extending the hinge length from 5 to 10, 16 and 22 mm increased the maximum principal stress around the hinge, and thus the fracture probability. A minimal effect on the results was observed by changing medial starting point of the cut from 30 to 35 and 40 mm. As a result, the extended finite element analyses confirmed the hypothesis that the extension of hinge segment increases the likelihood of a type II and type III fractures.

Evaluation of the efficacy of modal analysis in predicting the pullout strength of fixation bone screws.

Background: Pilot hole preparation has been shown to have an impact on the short and long-term stability of the screw fixation constructs. Purpose: Investigation and comparison of two nondestructive modal analysis methods with conventional insertion torque (IT) and pullout tests in optimum pilot hole diameter detection. Methods: Twenty conical core titanium screws were embedded in high-density polyethylene blocks with different pilot hole diameters. The maximum IT was recorded for each screw during implantation. Then, two modal analysis methods including accelerometer (classical modal analysis [CMA]) and acoustic modal analysis (AMA) were carried out to measure the natural frequency (NF) of the bone-screw structure. Finally, stiffness (S), pullout force (Fult), displacement at Fult (dult) and energy dissipation (ED) were obtained from the destructive pullout test. Results: The IT increased, as the pilot hole diameter decreased. The maximum value of IT was observed in the smallest pilot hole diameter. The same trend was found for the Fult and the first NF derived from both modal methods except for 5.5 mm pilot hole diameter. The natural NFs derived from CMA and AMA showed high correlations in different groups (R2 = 0.94) and did not deviate from y = x hypothesis in linear regression analysis. The Fult, dult, and ED were measured 4800 ± 172 N, 3.10 ± 0.08 mm and 14.23 ± 1.10 N.mm, respectively. Discussion: No significant change was observed in "S" between the groups. The highest Fult and first NF were obtained for the 5.5 mm pilot hole diameter. Both CMA and AMA were found to be reliable methods and can promote the undesirable contradiction between Fult and IT.

Homogenized finite element models can accurately predict screw pull-out in continuum materials, but not in porous materials.

BACKGROUND AND OBJECTIVE: Bone screw fixation can be estimated with several test methods such as insertion torque, pull-out, push-in and bending tests. A basic understanding of the relationship between screw fixation and bone microstructure is still lacking. Computational models can help clarify this relationship. The objective of the paper is to evaluate homogenized finite element (hFE) models of bone screw pull-out. METHODS: Experimental pull-out tests were performed on three materials: two polyurethane (PU) foams having a porous microstructure, and a high density polyethylene (HDPE) which is a continuum material. Forty-five titanium pedicle screws were inserted to 10, 20, and 30 mm in equally sized blocks of all three materials (N = 5/group). Pull-out characteristics i.e. stiffness (S), yield force (Fy), peak pull-out force (Fult) and displacement at Fult (dult) were measured. hFE models were created replicating the experiments. The screw was modeled as a rigid body and 5 mm axial displacement was applied to the head of the screw. Simulations were performed evaluating two different conditions at the bone-screw interface; once in which the screw fitted the pilot hole exactly ("free-stressed") and once in which interface stresses resulting from the insertion process were taken into account ("pre-stressed"). RESULTS: The simulations representing the pre-stressed condition in HDPE matched the experimental data well; S, Fy, and Fult differed less than 11%, 2% and 0.5% from the experimental data, respectively, whereas dult differed less than 16%. The free-stressed simulations were less accurate, especially stiffness (158% higher than the pre-stressed condition) and dult (30% lower than pre-stressed condition) were affected. The simulations representing PU did not match the experiments well. For the 20 mm insertion depth, S, Fy and Fult differed by more than 104%, 89% and 66%, respectively from the experimental values. Agreement did not improve for 10 and 30 mm insertion depths. CONCLUSIONS: We found that hFE models can accurately quantify screw pull-out in continuum materials such as HDPE, but not in materials with a porous structure, such as PU. Pre-stresses in the bone induced by the insertion process cannot be neglected and need to be included in the hFE simulations.

Influence of crack length and anatomical location on the fracture toughness of annulus fibrosus.

Fracture toughness (Jc) of a soft biological tissue is an important mechanical property that characterizes its resistance to crack or tear extension. To date, no information is available on fracture toughness of annulus fibrosus (AF); therefore, its defect tolerance is not known. The present study modified a previously introduced method to determine Jc of ovine AF. Then, the effect of the notch length on the failure pattern and Jc was investigated. Also, the test samples of anterior and lateral regions were collected to determine the effect of the location on Jc. Results showed that for a notch length of less than 45% of total width, no crack extension occurred, but for a notch length above 45% of the width, crack propagation and ultimately the failure of the AF were observed. However, statistical analysis indicated no significant difference on Jc (p = 0.5) for the initial notch length of 50% and 70% of total width. The fracture toughness was significantly higher for the samples extracted from the lateral site than those from the anterior site (p < 0.05). Dissimilar failure patterns were observed for different initial notch lengths. Among the parameters studied, the defect tolerance of AF was dependent on the initial tear size.

Design and Fabrication of a Drop Tower Testing Apparatus to Investigate the Impact Behavior of Spinal Motion Segments.

BACKGROUND: The vertebral column is the second most common fracture site in individuals with high-grade osteoporosis (30-50%). Most of these fractures are caused by falls. This information reveals the importance of considering impact loading conditions of spinal motion segments, while no commercial apparatus is available for this purpose. Therefore, the goal was set to fabricate an impact testing device for the measurement of impact behavior of the biological tissues. METHODS: In the present study, first, a drop-weight impact testing apparatus was designed and fabricated to record both force and displacement at a sample rate of 100 kHz. A load cell was placed under the sample, and an accelerometer was located on the impactor. Previous devices have mostly measured the force and not the deformation. Thereafter, the effect of high axial compression load was investigated on a biological sample, i.e., the lumbar motion segment, was investigated. To this end, nine ovine segments subjected to vertical impact load were examined using the fabricated device, and the mechanical properties of the lumbar segments were extracted and later compared with quasi-static loading results. RESULTS: The results indicated that the specimen stiffness and failure energy in impact loading were higher than those in the quasi-static loading. In terms of the damage site, fracture mainly occurred in the body of the vertebra during impact loading; although, during quasi-static loading, the fracture took place in the endplates. CONCLUSION: The present study introduces an inexpensive drop-test device capable of recording both the force and the deformation of the biological specimens when subjected to high-speed impacts. The mechanical properties of the spinal segments have also been extracted and compared with quasi-static loading results.

Does preconditioning lower the rupture resistance of chorioamniotic membrane?

Premature rupture of fetal membrane occurs in about 3% of all pregnancies. The physical integrity of chorioamnion (CA) membrane should be retained until delivery for a healthy pregnancy. To explore the effect of pre-conditioning and probe size on the mechanical properties of human chorioamniotic sac, the mechanical properties of 17 human chorioamniotic membranes, collected from cesarean delivery, were examined using biaxial puncture tests with and without preconditioning by different probe sizes. For preconditioned samples, the mean ± std. of ultimate rupture stress was calculated to be 1.73 ± 0.13, 1.61 ± 0.29 and 1.78 ± 0.26 MPa for the probe sizes of 3, 5 and 7 mm, respectively. For samples with no preconditioning, these values were calculated to be 2.38 ± 0.29, 2.36 ± 0.37, and 2.59 ± 0.43 MPa for the above-mentioned probe sizes. The force to probe diameter for samples with no preconditioning was in the range of 1087-1301 N/m for the three probe diameters, well in the range of 850-1580 N/m reported by previous studies. Our results show that the preconditioned samples had significantly lower ultimate puncture force and ultimate stress compared to non-preconditioned samples. In addition, a correlation between the probe size and the magnitude of puncture force was observed, while the stress values were not significantly affected by changing probe size.

Effect of geometric dimensions and material models of the periodontal ligament in orthodontic tooth movement.

OBJECTIVES: The aim of the present work was set to explore the role of root diameter, root length, and thickness of periodontal ligament (PDL) and its material properties (linear and non-linear elastic material models) on the stress and strain distribution, tooth displacement and centre of resistance (CR) location. SETTING AND SAMPLE POPULATION: Both the bone and the tooth were considered as rigid bodies, and the PDL was modelled as a paraboloid with different geometric dimensions and material properties. MATERIALS AND METHODS: To achieve this goal, a horizontal force of 1 N was applied in the CR location and the stress and strain distribution and tooth displacement were quantified. Locations of CR were estimated through iterative finite element procedure. RESULTS: It was predicted that the position of CR is in the range of 34%-39% of the root length, slightly higher than one-third of the root length reported in the literature. The geometrical dimensions of the PDL had no significant effect on the position of CR, especially in the non-linear material model of the PDL, while the initial displacement of the tooth was found to be highly dependent on the geometrical and mechanical properties of the PDL. CONCLUSION: The simplified PDL modelling approach with non-linear material behaviour can be suggested for the estimation of initial tooth movement for individual clinical applications without the use of advanced 3D scans.

Dynamic viscoelastic behavior of bovine periodontal ligament in compression.

BACKGROUND AND OBJECTIVE: As the main connector of teeth to the surrounding bone, the periodontal ligament (PDL) plays an important role in absorption and distribution of physiological and para-physiological loading. Despite the difference in the mechanical response of the PDL in tension and compression, little information is available on its viscoelastic behavior in compression. To explore the contribution of the fluid phase of the PDL, the aim of the present study was to measure its nonlinear time-dependent behavior in compression. MATERIAL AND METHODS: The in vitro dynamic compressive tests were carried out over a wide range of frequencies at three different preloads. Also, a generalized Maxwell model was proposed based on the experimental data to develop a viscoelastic model for subsequent computational analysis of the PDL. RESULTS: The higher values of loss factor in compression found in the range of 0.03-0.4 than those of 0.04-0.08 reported in tension, implies the focal role of the fluid phase in compressive dynamic response. Furthermore, the model parameters predicted that with an increase in preload, the role of the viscous components decrease, whereas the role of the elastic component increases. CONCLUSION: The viscous effect of the PDL in compression is greater than that in tension. Also, the dependence of the relaxation modulus of the bovine PDL on the applied load indicates its nonlinear viscoelastic behavior in compression.

Mechanical guidelines on the properties of human healthy arteries in the design and fabrication of vascular grafts: experimental tests and quasi-linear viscoelastic model.

PURPOSE: Knowledge of mechanical behavior of healthy human arteries as the guidelines to target properties of vascular grafts deserves special attention. There is a lack of mathematical model to characterize mechanical behavior of biomaterial while many mathematical models to reflect mechanics of human arteries have been proposed. The objective of this paper was set to measure mechanical properties of healthy human arteries including Common Carotid Artery (CCA), Abdominal Aorta Artery (AAA), Subclavian Artery (SA), Common Iliac Artery (CIA) and Right and Left Iliac Artery (RIA and LIA) and compare them to those of commercial ePTFE and Dacron®. METHODS: Series of stress relaxation and strain to failure tests vere performed on all samples. The experimental data was utilized to develop quasi-linear viscoelastic (QLV) model of both natural and artificial arteries. RESULTS: ePTFE is the stiffest sample, while the CCA is the most compliant one among all. RIA and CIA are more viscous than the other natural arteries, while AA and CCA are less viscous. The proposed model demonstrated an accurate fit to the experimental results, a proof of its ability to model both nonlinear elasticity and viscoelasticity of the human arteries and commercial ones. CONCLUSIONS: ePTFE and Dacron® are much stiffer than human arteries that may lead to the disruption of blood hemodynamic and may not be biomechanically feasible as a replacement.

Mechanical, material, and biological study of a PCL/bioactive glass bone scaffold: Importance of viscoelasticity.

Microsphere sintering method was used to fabricate bone tissue engineering scaffolds made of polycaprolactone (PCL)/bioactive glass 58S5Z (58S modified with 5 wt% Zinc). First, the effect of PCL/58S5Z ratio on the mechanical properties (elastic modulus and yield strength) was investigated. It was found that samples with 5 wt% 58S5Z (named 5%BG) had the highest elastic modulus and yield strength among all samples, i.e., with 0, 5, 10, and 20 wt% bioactive glass. Then, considering the importance of viscoelastic properties of bone, the viscoelastic behavior of 0%BG (scaffold with only PCL) and 5%BG samples was determined by performing compressive stress relaxation test and subsequently a Generalized Maxwell model was developed. Findings indicated a similar amount and pattern of predicted storage and loss moduli and loss factor of the composite scaffolds to those of the bone. In the next step, the analysis of biological behavior of the scaffolds using MTT assay, DAPI and Alizarin red staining demonstrated that 5%BG scaffolds had higher in vitro cell viability and bone formation compared to 0%BG ones. Furthermore, in vivo study employing H&E staining of the scaffolds implanted in rats' calvarium for 50 days, confirmed the earlier findings and showed that 5%BG-filled defects had higher and more uniform bone formation compared to both 0%BG-filled and empty defects.

Finite element investigation of human maxillary incisor under traumatic loading: Static vs dynamic analysis.

BACKGROUND AND OBJECTIVE: Traumatic loading is the main form of injury sustained in dental injuries. In spite of the prevalence of dental trauma, little information is available on traumatic dental damage and the evaluation of tooth behavior under traumatic loading. Due to the short period of traumatic loading, at first sight, a dynamic analysis needs to be performed to investigate the dental trauma. However, it was hypothesized that dental traumatic loading could be regarded as quasi-static loading. Thus, the aim of the present study was to examine this hypothesis. METHODS: Static and dynamic analyses of the human maxillary incisor were carried out under traumatic loading using a 3D finite element method. Also, modal analysis of the tooth model was performed in order to evaluate the assumption of the dental traumatic loading as a quasi-static one. RESULTS: It was revealed that the static analysis of dental trauma is preferred to the dynamic analysis when investigating dental trauma, mainly due to its lower computational cost. In fact, it was shown that including the inertia of the tooth structure does not influence the results of the dental trauma simulation. Furthermore, according to the modal analysis of the tooth structure, it was found that the mechanical properties and geometry of the periodontal ligament play significant roles in the classification of dental traumatic loading as a quasi-static one, in addition to the time duration of the applied load. CONCLUSIONS: This paper provides important biomechanical insights into the classification of dental loading as quasi-static, transient or impact loading in future dental studies.

Thermal Analysis of Dental Implants in Mandibular Premolar Region: 3D FEM Study.

PURPOSE: The distribution of temperature in a dental implant following hot food and beverage consumption is essential for evaluating the hazard this process may have on bone health. The purpose of this study was to predict the temperature distribution in the dental implant with/without a crown and the bone crest in contact with it using the finite element method. MATERIALS AND METHODS: A 3D model of the implant and the mandible was prepared by using computer-aided design software. Implants were investigated in three cases: without crown (BHI), with ceramic crown (MHIc), and with zirconia crown (MHIz). Subsequently, temperature distribution was numerically determined along the implant system for two heat loadings. RESULTS: In loading type I, the maximum temperature of the surrounding bone at the cervical implant/bone interface was obtained in the BHI model (39.1°C), and the lowest was obtained in the MHIc model (37.6°C). The maximum temperature rise in loading type II also took place in the BHI model (41.7°C). Moreover, the BHI model showed a rapid rise to the maximum temperature followed by a fast recovery compared to its two counterparts (MHIc, MHIz). In both loading types, the maximum temperature at the first point of contact between the implant and bone, and apical implant/bone interface was slightly higher in the MHIz than that in the MHIc. The maximum temperature in all the models was higher when subjected to cyclic loading. The maximum temperatures reached in all the models were lower than threshold temperatures, so thermal loading alone does not harm the jawbone. Moreover, the BHI was more vulnerable than the MHIc and the MHIz. CONCLUSIONS: The results of this study suggest that dental implants should be covered with crowns as soon as possible, and patients with dental implants should avoid consumption of hot food and beverages without allowing time for the heat to dissipate.

A comparison of the material properties of natural and synthetic vascular walls.

Characterization of the mechanical properties of native and synthetic vascular grafts is an essential task in the process of designing novel vascular constructs. The aim in this study was to compare the mechanical behavior of ovine left Subclavian artery with that of POSS-PCU (a commercial biomaterial which is currently under clinical investigation. ClinicalTrials.gov Identifier: NCT02301312). We used Delfino's strain energy potential within the framework of quasilinear viscoelasticity theory to capture the viscoelastic response of the considered materials. The material parameters of the quasilinear viscoelastic constitutive equation were determined through a combination of experimental and computational method. First, a uniaxial tensile testing device was used to perform a series of stress relaxation tests on ring samples. Then, the derived quasilinear viscoelastic models were implemented into finite element system. With the aid of mechanical experimentation and finite element simulation, the material parameters were obtained, modified and used for comparison of the mechanical properties of vascular walls. The results showed that the stiffness and the long term viscoelastic parameters of POSS-PCU may lead to different stress responses of the vascular walls. These two factors can be improved by modifications in manufacturing parameters of the synthetic vessel.

Biomechanical behavior of bovine periodontal ligament: Experimental tests and constitutive model.

A viscohyperelastic constitutive model with the use of the internal variables approach was formulated to evaluate the nonlinear elastic and time dependent anisotropic mechanical behavior of the periodontal ligament (PDL). Since the relaxation response was found to depend on the applied stretch, the adoption of the nonlinear viscous behavior in the present model was necessary. In this paper, Helmholtz free energy function was assigned to the material as the sum of hyperelastic and viscous terms which is based on the physical concept of internal variables. The constitutive model parameters were evaluated from the comparison of the proposed model and experimental data. For this purpose, tensile response of the bovine PDL samples under different stretch rates was obtained. The good correspondence between the proposed model and the experimental results confirmed the capability of the model to interpret the stretch rate behavior of the PDL. Moreover, the validity of structural model parameters was checked according to the results of the stress relaxation tests.