ABSTRACT
Heterocyclic chemistry is a large field with diverse applications in the areas of biological research and pharmaceutical advancement. Numerous initiatives have been proposed to further enhance the reaction conditions to reach these compounds without using harmful compounds. This paper focuses on the recent advances in the eco-friendly and green synthetic procedures to synthesize N-, S-, and O-heterocycles. This approach demonstrates considerable potential in accessing such compounds while circumventing the need for stoichiometric quantities of oxidizing/reducing agents or catalysts containing precious metals. Merely employing catalytic quantities of these substances proves sufficient, thereby offering an optimal means of contributing to resource efficiency. Renewable electricity plays a crucial role in generating environmentally friendly electrons (oxidant/reductant) that serve as catalysts for a series of reactions. These reactions involve the production of reactive intermediates, which in turn allow the synthesis of new chemical bonds, enabling beneficial transformations to occur. Furthermore, the utilization of metals as active catalysts in electrochemical activation has been recognized as an effective approach for achieving selective functionalization. The aim of this review was to summarize the electrochemical synthetic procedures so that the undesirable side reactions can be considerably reduced and the practical potential range of the chemical reactions can be expanded significantly.
ABSTRACT
This article summarizes the most recent advancements in the synthetic and pharmacological approaches along with the structure activity relationship towards the s-triazine and its derivatives. Much attention has been given to s-triazine core due to its facile synthesis, interesting pharmacology, high reactivity, and binding characteristics towards various enzymes. An array of biological applications has been demonstrated by s-triazines including antimalarial, anti-HIV, anti-viral, antimicrobial, anti-tuberculosis to name a few. In the present investigation s-triazine based molecular structures have been assembled in respect to their synthesis and medicinal properties. Further, the competence of s-triazine has been correlated and compared with the other heterocyclic moieties to substantiates-triazine a privileged scaffold. From the literature it is revealed that nucleophilic substitution at 2, 4, and 6 positions is significant for various biological applications. This article would help in assisting the chemists in designing novel molecular entities with high medicinal value.
