1.
Carcinogenesis
; 4(9): 1179-83, 1983 Sep.
Article
in English
| MEDLINE
| ID: mdl-6349845
ABSTRACT
Twenty bile acid or cholesterol derivatives were tested for mutagenicity by the Ames spot test procedure against five Salmonella typhimurium strains in the presence and absence of rat liver microsomes. No strong mutagens were identified, but four of the compounds increased the number of revertant colonies observed. Three of these compounds were selected for dose response experiments using the Ames plate incorporation assay procedure with strain TA 1538. No positive results were obtained. These results suggest that none of the twenty bile acid derivatives tested is likely to be the initiating agent in the aetiology of colon cancer.
Subject(s)
Bile Acids and Salts/toxicity , Cholesterol/analogs & derivatives , Mutagens , Mutation , Animals , Biotransformation , Cholesterol/toxicity , Male , Microsomes, Liver/metabolism , Mutagenicity Tests , Rats , Rats, Inbred Strains , Salmonella typhimurium/drug effects , Structure-Activity Relationship
2.
Virology
; 49(3): 758-65, 1972 Sep.
Article
in English
| MEDLINE
| ID: mdl-5072635
Subject(s)
Neuraminidase/analysis , Orthomyxoviridae/analysis , Peptides/analysis , Viral Proteins/analysis , Amino Acids/metabolism , Carbon Isotopes , Centrifugation, Density Gradient , Electrophoresis, Polyacrylamide Gel , Glucosamine/analysis , Glucosamine/metabolism , Glycoproteins/analysis , Iodine Isotopes , Molecular Weight , Neuraminidase/isolation & purification , Neuraminidase/metabolism , Orthomyxoviridae/enzymology , Sodium Dodecyl Sulfate , Sucrose , Tritium , Trypsin , Valine/metabolism
3.
Virology
; 46(3): 764-73, 1971 Dec.
Article
in English
| MEDLINE
| ID: mdl-5167658
Subject(s)
Iodine , Orthomyxoviridae/analysis , Peptides/isolation & purification , Viral Proteins/analysis , Amino Acids , Animals , Carbon Isotopes , Cattle , Chick Embryo , Chloramines , Culture Techniques , Electrophoresis, Disc , Glycopeptides/analysis , Glycopeptides/isolation & purification , Hemagglutinins, Viral/analysis , Hemagglutinins, Viral/isolation & purification , Iodine Isotopes , Kidney , Lactates , Methods , Molecular Weight , Orthomyxoviridae/isolation & purification , Peptides/analysis , Peroxidases , Sodium , Sulfates , Sulfur Isotopes , Tritium , Viral Proteins/isolation & purification , Virus Cultivation
4.
Virology
; 42(3): 555-65, 1970 Nov.
Article
in English
| MEDLINE
| ID: mdl-5529976
Subject(s)
Electrophoresis , Orthomyxoviridae/analysis , Peptides/analysis , Acrylates , Amino Acids/analysis , Animals , Carbon Isotopes , Cattle , Centrifugation, Density Gradient , Chick Embryo , Culture Media , Culture Techniques , Gels , Glycoproteins/analysis , Indicators and Reagents , Kidney , Methods , Orthomyxoviridae/growth & development , Orthomyxoviridae/isolation & purification , Potassium , Sodium , Sucrose , Sulfates , Tartrates , Tritium , Urea
5.
Virology
; 42(3): 566-75, 1970 Nov.
Article
in English
| MEDLINE
| ID: mdl-5529977
Subject(s)
Antigens/analysis , Neuraminidase/analysis , Orthomyxoviridae/analysis , Peptides/analysis , Viral Proteins/analysis , Acrylates , Amino Acids , Animals , Carbon Isotopes , Cattle , Centrifugation, Density Gradient , Chick Embryo , Culture Techniques , Electrophoresis , Gels , Glycoproteins/analysis , Hemagglutinins, Viral/analysis , Hemagglutinins, Viral/isolation & purification , Indicators and Reagents , Kidney , Molecular Weight , Neuraminidase/isolation & purification , Orthomyxoviridae/enzymology , Orthomyxoviridae/growth & development , Orthomyxoviridae/immunology , Sodium , Sucrose , Sulfates
6.
Virology
; 39(1): 118-29, 1969 Sep.
Article
in English
| MEDLINE
| ID: mdl-5807968