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H1N1 pneumonitis associated with long-term non-steroidal anti-inflammatory drug abuse.

Prower, Emma; Hasnain, Ozair; Oscier, Chris.

BMJ Case Rep ; 20152015 Apr 13.

Article in English | MEDLINE | ID: mdl-25870210

ABSTRACT

This case series discusses two similar presentations of H1N1 influenza in young patients with a background history of long-term non-steroidal anti-inflammatory drug (NSAID) abuse. Both patients presented with type 1 respiratory failure requiring intensive care unit admission and subsequent organ support. This report reviews the immunosuppressive effects of long-term NSAID use and highlights a potential link to the significant morbidity seen.

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Influenza A Virus, H1N1 Subtype/isolation & purification , Influenza, Human/chemically induced , Pneumonia/chemically induced , Adult , Anti-Inflammatory Agents, Non-Steroidal/standards , Humans , Influenza, Human/immunology , Influenza, Human/virology , Intensive Care Units , Male , Middle Aged , Pneumonia/drug therapy , Pneumonia/immunology , Pneumonia/virology , Respiration, Artificial , Respiratory Distress Syndrome/chemically induced , Respiratory Distress Syndrome/immunology , Respiratory Distress Syndrome/virology , Respiratory Insufficiency/chemically induced , Respiratory Insufficiency/virology , Systemic Inflammatory Response Syndrome/chemically induced , Systemic Inflammatory Response Syndrome/immunology , Systemic Inflammatory Response Syndrome/virology

ABSTRACT

Subject(s)

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