Subject(s)
Keratosis/etiology , PUVA Therapy/adverse effects , Vitiligo/drug therapy , Adult , Female , Humans , Keratosis/pathology , MaleABSTRACT
A child had cerebral palsy and linear and whorled nevoid hypermelanosis on the right side of his body. He had spasticity and wasting in both lower limbs, with electroencephalographic changes and brain abnormalities on computerized tomographic scan. Chromosomal study of peripheral blood leukocytes found a normal male karyotype. The pathogenesis of this condition is still unclear.
Subject(s)
Cerebral Palsy/complications , Melanosis/pathology , Brain/diagnostic imaging , Brain/pathology , Cerebral Palsy/diagnostic imaging , Cerebral Palsy/genetics , Child, Preschool , Electroencephalography , Humans , Karyotyping , Leg , Male , Melanins/analysis , Melanosis/complications , Muscle Spasticity , Muscular Atrophy/pathology , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Although the basement membrane (BM) phenomenon is considered a good test to differentiate between systemic (SLE) and discoid lupus erythematosus (DLE), our observations question its reliability. METHODS: Direct immunofluorescence stain was done to detect immunoglobulins and complement deposits in 10 SLE patients and in 10 healthy controls. Specimens were taken from the normal skin of the dorsa of hands. RESULTS: The group of SLE patients showed deposits of IgG in 4, IgM in 7, IgA in 1, C3 in 7, and C4 in 1 patient. The group of healthy controls showed IgM in 2, C3 in 5, C4 in 2 cases, but no IgG or IgA deposits. CONCLUSION: A positive BM phenomenon test could be found in normal individuals and may be due to the effect of ultraviolet rays. We think that the BM phenomenon has a limited reliability in diagnosing SLE.
Subject(s)
Immunoglobulin G/metabolism , Immunoglobulin M/metabolism , Lupus Erythematosus, Systemic/diagnosis , Skin/immunology , Basement Membrane/immunology , Basement Membrane/pathology , Complement C3/metabolism , Diagnosis, Differential , Fluorescent Antibody Technique , Humans , Lupus Erythematosus, Discoid/diagnosis , Lupus Erythematosus, Systemic/immunology , Lupus Erythematosus, Systemic/pathology , Skin/pathologySubject(s)
Hamartoma/genetics , Skin Diseases/genetics , Adult , Child , Child, Preschool , Female , Hamartoma/pathology , Humans , Male , Pedigree , Skin/pathology , Skin Diseases/pathologyABSTRACT
Four patients suffering from pigmented actinic lichen planus were studied. Clinically, the lesions are melasma-like, affecting mainly the face and exacerbating in summer and spring time. The histopathologic and immunofluorescence studies showed typical changes of actinic lichen planus. The possibility of pigmented actinic lichen planus should be considered in every patient with facial melanosis.
Subject(s)
Facial Dermatoses/pathology , Lichen Planus/pathology , Melanosis/pathology , Adult , Child , Female , Fluorescent Antibody Technique , Humans , Male , Middle Aged , Skin/pathologyABSTRACT
A 10-year-old girl had two localized psoriasiform plaques at birth. Subsequently, she developed generalized, asymptomatic, scaly plaques arranged in linear bands and streaks along the lines of Blaschko. The morphologic and histopathologic features, the clinical course, and HLA (CW6,A2) association were characteristic of psoriasis. Although rare, true linear psoriasis exists.
Subject(s)
Psoriasis/congenital , Child , Female , HLA Antigens/analysis , Humans , PUVA Therapy , Psoriasis/drug therapy , Psoriasis/pathology , Tonsillitis/complicationsABSTRACT
Sixty-four specimens of mixed tumors of the skin were studied by conventional microscopy. Sections from all 64 specimens were stained by hematoxylin and eosin, and sections from 18 of those specimens were stained by immunoperoxidase techniques for the presence of S-100 protein, carcino-embryonic antigen (CEA), keratin, actin, vimentin, epithelial membrane antigen (EMA), and gross cystic disease fluid protein-15 (GCDFP-15). Two distinctive histopathological patterns of mixed tumors of the skin became apparent, namely, apocrine and eccrine. Mixed tumors with apocrine features are by far the most common. Immunoperoxidase techniques, in our experience, do not enable differentiation between apocrine and eccrine types of mixed tumors.
