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19alpha-Hydroxy-3-oxo-ursa-1,12-dien-28-oic acid, an antiplasmodial triterpenoid isolated from Canthium multiflorum.
Traoré-Coulibaly, Maminata; Ziegler, Hanne L; Olsen, Carl Erik; Hassanata, Millogo-kone; Pierre, Guissou I; Nacoulma, Odile G; Guiguemdé, T Rober; Christensen, S Brøgger.
Nat Prod Res ; 23(12): 1108-11, 2009.
Article in English | MEDLINE | ID: mdl-19662575

ABSTRACT

A bioactivity guided fractionation of roots of Canthium multiflorum led to the isolation of the new ursenoic acid derivative 19alpha-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid (1), which showed antiplasmodial effect without inducing change of the shape of membranes of erythrocytes.


Subject(s)
Antimalarials/isolation & purification , Antimalarials/pharmacology , Plasmodium falciparum/drug effects , Rubiaceae/chemistry , Triterpenes/isolation & purification , Triterpenes/pharmacology , Animals , Antimalarials/chemistry , Erythrocytes/drug effects , Humans , Magnetic Resonance Spectroscopy , Molecular Structure , Triterpenes/chemistry
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