ABSTRACT
Although autologous tandem hematopoietic SCT has improved the prognosis of patients with advanced high-risk neuroblastoma, the results remain unsatisfactory. In an attempt to induce the graft-versus-tumor effect, we performed autologous PBSCT followed by allogeneic cord blood transplantation in three consecutive advanced neuroblastoma cases with marked BM infiltration and high MYCN amplification. Severe acute complications did not occur in any patient and they have maintained disease-free survival for 37-60 months. This strategy appears to be feasible and effective for the treatment of extremely high-risk neuroblastoma cases.
Subject(s)
Cord Blood Stem Cell Transplantation/methods , Neuroblastoma/therapy , Nuclear Proteins/genetics , Oncogene Proteins/genetics , Peripheral Blood Stem Cell Transplantation/methods , Bone Marrow/pathology , Graft vs Tumor Effect , Hematopoietic Stem Cell Transplantation/methods , Humans , Infant , Male , N-Myc Proto-Oncogene Protein , Neoplasm InvasivenessABSTRACT
Cryoablation in the left ventricular outflow tract and aortic valve replacement were conducted in a 70-year-old man with frequent premature ventricular contraction and nonsustained ventricular tachycardia complicated by Sellers grade 4 aortic regurgitation. The earliest endocardial activation site during premature ventricular contraction was confirmed by a preoperative electrophysiological study of the left sinus of Valsalva. Cryoablation preceded valvulectomy followed by aortic valve replacement. Clinical symptoms of premature ventricular contraction disappeared immediately after surgery.
