Which intellectual activities are related to cognitive reserve? Introduction and testing a three-dimensional model.

BACKGROUND: A common belief among people and some researchers is that keeping yourself mentally active may decrease the risk of dementia. Over the past years, despite widespread efforts to identify proxies for protecting cognitive reserve against age-related changes, it is still not clear what type of intellectual activity would be beneficial for cognitive reserve. To fill this gap, we propose a three-dimensional model of intellectual activity. According to this conceptual model, intellectual activities could be distinguished based on their locations in a three-dimensions space, including; (1) Activation: active vs. passive, (2) Novelty: novel vs. familiar, and (3) Productivity: productive vs. receptive. We assumed that the activities that are categorized as more active, novel, and productive could be considered as a cognitive reserve proxy. METHODS: To test this hypothesis, a sample of 237 participants older than 50 years (Mage = 58.76 ± 6.66; 63.7% women) was recruited to take part in the study. Episodic, semantic and working memory were assessed with computerized battery tests (Sepidar) and a self-report questionnaire was used to assess intellectual activities. Activities were categorized in terms of; (1) passive, familiar, and receptive activities (radio/watching TV), (2) active, familiar, and receptive activities (solving crosswords), (3) active, novel, and receptive activities (reading), and (4) active, novel, and productive activities (writing). RESULTS: The results indicated that writing moderates the effect of age on episodic and semantic memory. Reading only moderates the effect of age on semantic memory, and radio/watching TV and solving crosswords do not play a role in moderation analysis. CONCLUSIONS: Our finding suggests that intellectual activities have different moderating effects on the relationships between age and memory performance. Individuals with high levels of participation in novel and productive activities over the life course are less likely to clinically demonstrate cognitive impairments. Our results support the potential benefit of the three-dimensional model to provide a better insight into the complex role of intellectual activities in cognitive reserve, particularly for older adults. Further research is needed to evaluate the efficacy and the benefits of the model.

The Role of Cognitive Control in Paranormal Beliefs: A Study Based on Performance in Go/No-go Task.

Introduction: Cognitive control plays a role in human behavior and mental processes and affects paranormal beliefs. This study aims to investigate the role of cognitive control in paranormal beliefs using the go/no-go task. Methods: A total of 92 people were selected based on low, middle, and high scores in the revised paranormal belief scale (R-PBS) and assigned to 3 groups. The groups included 30 severe paranormal believers (13 females with a mean age of 25.3 years), 31 mild paranormal believers (14 females with a mean age of 26.4 years), and 31 skeptics (16 females with a mean age of 25.8 years). All participants were tested on the go/no-go task. A multivariate analysis of variance was conducted with the given groups (severe paranormal believers, mild paranormal believers, and skeptics) as the independent variable and the go/no-go subscales scores as dependent variables. Results: The findings showed a significant difference between the mean scores in errors of go (F(2, 89)=7.20, P=0.01), errors of no-go (F(2, 89)=11.81, P=0.01), and reaction time (F(2, 89)=21.46, P=0.01) between the groups. Conclusion: The severe and mild paranormal believers had lower accuracy and slower reaction times than the skeptics group. Therefore, severe paranormal believers and mild paranormal believers had a weakness in all go/no-go subscale scores. This finding suggests that paranormal beliefs may be related to poor cognitive control. Highlights: Believers show weak cognitive control.Skeptics perform better in accuracy and reaction time.Paranormal beliefs linked to poor cognitive control. Plain Language Summary: This study explores why some people strongly believe in paranormal phenomena while others don't. This study investigated the connection between cognitive control (our ability to manage thoughts and behavior) and paranormal beliefs. They found that individuals with stronger paranormal beliefs had poorer cognitive control, as they made more errors and had slower reaction times compared to skeptics. However, it's important to note that this study doesn't prove causation; it only highlights a potential link that needs more research. Understanding this connection is important because it helps us grasp why some people are more prone to believing in paranormal events. It also opens up avenues for studying how cognitive control affects human behavior and thinking. In conclusion, this study provides valuable insights into the relationship between cognitive control and paranormal beliefs, contributing to our understanding of human behavior and belief systems. More research can further deepen our knowledge of why people hold different beliefs and how cognitive processes influence those beliefs.

Differential Cortical Oscillatory Patterns in Amputees With and Without Phantom Limb Pain.

Introduction: Phantom limb pain (PLP) as neuropathic pain affects the life of amputees. It is believed an efficient PLP treatment should consider the underlying neurological mechanisms. Hereby, we investigated brain activity in PLP and its relationships to the psychological and cognitive dimensions of chronic pain. We investigate differences in resting brain activities between amputees with and without pain. We hypothesize significant differences in the motor cortex and parietal cortex activity that are related to pain perception. Also, we hypothesize two groups have significant differences in cognitive and psychological components. Methods: Behavioral assessment (psychological status, life satisfaction, and pain level) and EEG signals of 19 amputees (12 without pain and 7 with pain) were recorded. Data were statistically compared between the two groups. Also, the association between behavioral and neurophysiological data was computed. Results: The results showed a significant decrease in the pain group for the beta and gamma waves, as well as, for the theta and delta waves in the posterior temporal on both sides, during the eye-open condition. The eyes-closed condition showed that the delta waves were decreased on the right side of the cortex. Also, data showed a significant difference in the correlation of pain features with brain waves between the two groups. Conclusion: Significant differences were mostly observed in regions related to pain perception rather than the motor cortex. This can be due to the learned strategies to deal with pain and the degree of pain. Results showed maladaptive cognitive processes had a relationship with brain wave activities. According to the result of brain wave activities, it seems that cognitive factors have a role in the experience of PLP rather than neuroplasticity through amputation. Highlights: Differences found in the parietal and temporal regions of phantom limb pain's (PLP's) suggests cognition's role in the persistence of PLP.Decreased delta power at the posterior temporal cortex in PLP's could be the focus of treatments.Increased activity of the parietal cortex could be helpful in the treatment of PLP's. Plain Language Summary: PLP is an annoying neurologic pain. A wide range of treatments have focused on this type of pain but couldn't be effective. Recently, researchers suggest BCI-based treatments for better treatment. For this type of treatment, we should know the neurological aspect of PLP. In most studies to investigate or treatment of neurological aspects of PLP, researchers induced pain experimentally or studied acute phantom limb pain. We believed for a better understanding of PLP, should investigate it in a natural and stabilized position. Therefore we studied brain activities in amputees with and without PLP in a resting state to find out differences. Trends in this field express the alpha band differences in the motor cortex. On the contrary, our results showed the most significant difference in high-frequency bandpasses such as beta and gamma. Also, in our study, it seems the parietal and temporal cortex that are related to pain perception is the more relevant to PLP. This study showed a psycho-cognitive aspect of pain such as pain exaggeration has a relation with PLP's brain wave activities. So, we can suggest rather than neuroplasticity through amputation, cognitive factors have a role in the experience of PLP.

Conspiracy beliefs are associated with a reduction in frontal beta power and biases in categorizing ambiguous stimuli.

Prior beliefs, such as conspiracy beliefs, significantly influence our perception of the natural world. However, the brain activity associated with perceptual decision-making in conspiracy beliefs is not well understood. To shed light on this topic, we conducted a study examining the EEG activity of believers, and skeptics during resting state with perceptual decision-making task. Our study shows that conspiracy beliefs are related to the reduced power of beta frequency band. Furthermore, skeptics tended to misclassify ambiguous face stimuli as houses more frequently than believers. These results help to explain the differences in brain activity between believers and skeptics, especially in how conspiracy beliefs impact the categorization of ambiguous stimuli.

Aging decreases the precision of visual working memory.

OBJECTIVES: As individuals age, cognitive abilities such as working memory (WM), decline. In the current study, we investigated the effect of age on WM, and elucidated sources of errors. METHOD: A total of 102 healthy individuals, aged 18 to 71, participated in this research. We designed and administered a face-based visual WM task, collecting responses via a graded scale in a delayed match-to-sample reproduction task. RESULTS: The error of participants increased significantly as they aged. Our analysis revealed a significant age-related rise in the standard deviation of error distribution. However, there was no significant change in uniform probability with age. CONCLUSION: We found that WM performance declines through the lifespan. Investigating the sources of error, we found that the precision of WM decreased monotonously with age. The results also indicated that the probability of guessing the response as a measure of random response is not affected by age.

Impact of negative links on the structural balance of brain functional network during emotion processing.

Activation of specific brain areas and synchrony between them has a major role in process of emotions. Nevertheless, impact of anti-synchrony (negative links) in this process still requires to be understood. In this study, we hypothesized that quantity and topology of negative links could influence a network stability by changing of quality of its triadic associations. Therefore, a group of healthy participants were exposed to pleasant and unpleasant images while their brain responses were recorded. Subsequently, functional connectivity networks were estimated and quantity of negative links, balanced and imbalanced triads, tendency to make negative hubs, and balance energy levels of two conditions were compared. The findings indicated that perception of pleasant stimuli was associated with higher amount of negative links with a lower tendency to make a hub in theta band; while the opposite scenario was observed in beta band. It was accompanied with smaller number of imbalanced triads and more stable network in theta band, and smaller number of balanced triads and less stable network in beta band. The findings highlighted that inter regional communications require less changes to receive new information from unpleasant stimuli, although by decrement in beta band stability prepares the network for the upcoming events.

Paranormal believers show reduced resting EEG beta band oscillations and inhibitory control than skeptics.

Paranormal believers' thinking is frequently biased by intuitive beliefs. Lack of inhibition of these tempting beliefs is considered a key element in paranormal believers' thinking. However, the brain activity related to inhibitory control in paranormal believers is poorly understood. We examined EEG activities at resting state in alpha, beta, and gamma bands with inhibitory control in paranormal believers and skeptics. The present study shows that paranormal belief is related to the reduced power of the alpha, beta, and gamma frequency bands, and reduced inhibitory control. This study may contribute to understanding the differences between believers and skeptics in brain activity related to inhibitory control in paranormal believers.

Resting-State Electroencephalogram (EEG) Coherence Over Frontal Regions in Paranormal Beliefs.

Introduction: Paranormal beliefs are defined as the belief in extrasensory perception, precognition, witchcraft, and telekinesis, magical thinking, psychokinesis, superstitions. Previous studies corroborate that executive brain functions underpin paranormal beliefs. To test this hypotheses, neurophysiological studies of brain activity are required. Methods: A sample of 20 students (10 girls, Mean±SD age: 22.50±4.07 years) were included in the current study. The absolute power of resting-state electroencephalogram (EEG) was analyzed in intra-hemispheric and inter-hemispheric coherence with eyes open. The paranormal beliefs were determined based on the total score of the revised paranormal belief scale (RPBS). Results: The results of this study demonstrated a significant negative relationship between paranormal beliefs and resting-state EEG in alpha band activity in the frontal lobe (left hemisphere), EEG coherence of alpha and ß1, ß2, and gamma band activities in the frontal lobe (right hemisphere) and coherence of alpha and ß1, ß2 and gamma band activities between frontal regions (two hemispheres). In addition, the results showed that coherence of α, α1, ß, and ß2 band activities between the frontal lobe (right hemispheres) and the EEG coherence of Δ, α1, and beta band activities in the frontal lobe (two hemispheres) predict paranormal beliefs. Conclusion: This study confirms the connection of executive brain functions to paranormal beliefs and determines that frontal brain function may contribute to paranormal beliefs. Highlights: Paranormal beliefs were negatively related to the EEG coherence.Paranormal beliefs were associated with EEG coherence in the right frontal lobe.We found a negative correlation between paranormal beliefs and the EEG coherence in the frontal lobes.EEG coherence the frontal lobes predicted paranormal beliefs. Plain Language Summary: Paranormal beliefs were negatively related to the EEG coherence. They were associated with EEG coherence in the right frontal lobe. In this study, we found a negative correlation between paranormal beliefs and the EEG coherence in the frontal lobes. EEG coherence the frontal lobes predicted paranormal beliefs.

Prediction of delay discounting in intertemporal decisions by future thinking: Accounting for fluency, contents, and functions of future thoughts.

PURPOSE: To study the variations of delay discounting rates as a function of fluency, contents, and functions of future thoughts in healthy subjects. BACKGROUND: Delay discounting (DD) is a concept that can measure a frequent tendency toward smaller, yet immediate rewards, while a delayed reward is greater in value. DD describes people's choices in intertemporal decisions and is associated with self-control. Future thinking (FT) and having a vivid imagination of the future can reduce individuals' DD rates. However, constructing a specific episodic future representation was merely studied in relation to DD. Although fluency and contents of future thoughts have been reported related to various disorders and behaviors, their association with DD has not been previously addressed. METHODS: The present study applies a verbal fluency task named the personal future task (PFT), the functions of future thinking scale (FoFTS), and the 27-item delay discounting questionnaire (DDQ) in order to assess fluency, contents, and functions of future thoughts, and delay discounting in healthy subjects (N = 114, Female = 64%, Male = 36%, Mage = 34.22, SDage = 7.15). RESULTS: Findings indicate that fluency of future thoughts is associated with DD. Among the contents of FT categories, financial contents (future thoughts about money and real estate matters), and regarding functions of FT, engaging in FT for planning are related to DD. Due to the final model, the above-mentioned correlated variables can be considered as significant predictors of intertemporal choices when controlling for education and gender (R2  = 0.4, Adjusted R2  = 0.33, F = 5.186, p-value = 0.001). CONCLUSION: The frequency of future thoughts one can generate, specifically future thoughts about financial contents, is associated with less short-sighted intertemporal decisions. The former relationship is enhanced for longer delays (e.g., 5-10 years). Besides, individuals who frequently engage in FT for planning (planning out sequences of actions) discount future rewards to a lesser extent.

The Lifetime of Experiences Questionnaire: Psychometric Properties and Relationships With Memory Function in an Iranian Elderly Sample.

This study aimed to validate the Persian version of the Lifetime of Experiences Questionnaire (LEQ) and examine the relationship between life experience and memory function. To this end, two studies were conducted. Study one examined the factor structure, internal consistency, and convergent and discriminant validity of the Persian version of LEQ with 247 healthy elderly individuals (M age = 70.17, SD = 4.42; 55.9% women). The exploratory factor analysis yielded a five-factor solution, including Knowledge, Physical, Socialization, Artistic, and Leisure dimensions, which accounted for 42.42% of the explained variance. The internal consistency of the LEQ was in the acceptable range (α = 0.703). Also, the LEQ and its subscales (except the Artistic subscale) had a negative relationship with geriatric depression and a positive relationship with a healthy lifestyle, supporting the measure's convergent and discriminant validity. In the second study, we examined the relationship between LEQ (total and subscales score) and memory function using Pearson correlation and moderating analysis with 149 participants (M age = 70.37, SD = 4.29; 55.03% women). The results demonstrated that the LEQ total and subscales scores correlated positively with episodic memory. In the same vein, LEQ total score and Knowledge subscale showed a positive correlation with semantic memory. The results of moderation analysis showed that LEQ subscales have a different role in memory decline. The knowledge subscale as a content component moderates the effect of age on semantic memory (B = 0.005, t = 2.021, p = 0.045), while the mid-life non-specific activities, which are based on life stages, moderate the effect of age on episodic memory (B = 0.007, t = 3.348, p = 0.001). In conclusion, our results indicated that the Persian version of the LEQ is a valid and reliable instrument for measuring experiences and activities throughout life, which can be used in professional clinical and research settings in the aging context with Iranian elderly samples. Furthermore, our findings suggest that various life experiences can be considered cognitive reserves in old age.

Culture as an effective frame of reference in clinical decision-making: A comparison of Iranian, American, and Canadian psychotherapists.

The therapeutic communication between psychotherapist and client is highly dependent on their socio-cultural background. The purpose of this study was to examine the effects of culture on decision-making style of psychotherapists in three dimensions of decision-making: expedience vs. realism, individualism vs. collectivism, and long-term orientation vs. short-term orientation. The sample of this study consisted of 144 psychotherapists (40 Iranians educated in Iran, 33 Iranians educated in the west, 36 Americans, and 35 Canadians). Each of the participants were presented with three scenario that involved clinical challenging situations. For each area of decision-making a statement was considered and the psychotherapist was requested to rate them based on importance in his/her clinical decision-making. Findings indicated that the groups differed significantly on all dimensions with few exceptions when American and Canadian psychotherapists were compared. The decision-making style of Iranian psychotherapists was more with expediency, collectivism and long-term orientation, while the decision-making style of American and Canadian psychotherapists was more with realism, individualism, and short-term orientation. According to the results of current study, socio-cultural background of psychotherapists, as a frame of reference, significantly influenced their clinical decision-making style.

Citizens of the world: National stereotypes do not affect empathic response in the presence of individuating information.

Stereotyping is defined as generalising an attribute to a whole group and overlooking individual differences. In this study, we investigated whether Iranians' stereotypes of nations affected their empathy for the citizens of those nations. First, in a pilot study we explored common national stereotypes by using the stereotype content model (SCM) based on which six countries with different perceived warmth and competence scores were selected as nationalities of the protagonists of the vignettes in our experiment. In the next phase, 21 participants were asked to rate the degree of sadness associated with each vignette in an fMRI scanner. The results showed no significant differences in brain activity while participants were exposed to scenarios in which negative events befell people from different nations. This may be due to the individuation of victims by providing personal information about them.

How do cannabis users mentally travel in time? Evidence from an fMRI study of episodic future thinking.

RATIONALE: Episodic future thinking (EFT) is a cognitive function that allows individuals to imagine novel experiences that may happen in the future. Prior studies show that EFT is impaired in different groups of substance users. However, there is no evidence regarding the neurobiological mechanisms of EFT in cannabis users. OBJECTIVES: We aimed to compare brain activations of regular cannabis users and non-using controls during an EFT fMRI task. Exploratory analyses were also conducted to investigate the association between EFT and cannabis use variables (e.g., duration of use, age onset, frequency of use). METHODS: Twenty current cannabis users and 22 drug-naïve controls underwent an fMRI scanning session while completing a task involving envisioning future-related events and retrieval of past memories as a control condition. The EFT fMRI task was adapted from the autobiographical interview and composed of 20 auditory cue sentences (10 cues for past and 10 cues for future events). Participants were asked to recall a past or generate a future event, in response to the cues, and then rate their vividness after each response. RESULTS: We found that cannabis users compared to non-user controls had lower activation within the cerebellum, medial and superior temporal gyrus, lateral occipital cortex, and occipital fusiform gyrus while envisioning future events. Cannabis users rated the vividness of past events significantly lower than non-users (P < 0.005). There were marginal group differences for rating the vividness of future events (P = 0.052). Significant correlations were also found between the medial and superior temporal gyrus activities and behavioral measures of EFT and episodic memory. CONCLUSIONS: Cannabis users, compared to drug-naïve controls, have lower brain activation in EFT relevant regions. Thus, any attempts to improve aberrant EFT performance in cannabis users may benefit from EFT training.

Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder.

BACKGROUND: Impaired cognitive functions, particularly executive function, predicts poor treatment success in people with substance use disorders. The current study investigated the effect of receiving adjunct cognitive rehabilitation and baseline executive function (EF) measures on treatment response among people with opioid use disorder (OUD). METHOD: The analysis sample consisted of 113 participants with OUD who were discharged from a compulsory court-mandated methadone maintenance treatment (MMT) and followed for 3 months. We used the Backward digit span/Auditory verbal learning, Stroop, and Trail making tests to assess the three measures of EF, including working memory, inhibition, and shifting, respectively. Treatment response was operationalized as (1) treatment retention and (2) the number of positive urine tests for morphine during 3-month follow-up periods. The study used Cox's proportional hazards model and linear mixed model to identify predictive factors. RESULTS: Lower Stroop interference scores predicted increased length of stay in treatment (χ2 = 33.15, P < 0.001). The linear mixed model showed that scores on auditory verbal learning test and group intervention predicted the number of positive urine tests during a 3-month follow-up. CONCLUSION: Working memory and inhibitory control, as well as receiving cognitive rehabilitation, could be potentially considered as predictors of treatment response for newly MMT admitted patients with OUD. Assessment of EF before treatment initiation may inform treatment providers about patient's cognitive deficits that may interfere with therapeutic interventions.

Production of recombinant lethal factor of Bacillus anthracis in Bacillus subtilis.

Cancer is considered as a disease with high rates of mortality and morbidity. The limitations and side effects of common treatments have prompted the need for innovative cancer therapies. Furthermore, selectivity and targeting of cancer cells are crucial factors to successful treatment of cancer. One of these methods is the use of bacterial toxins including Bacillus anthracis toxin to aid cancer therapy. This toxin is composed of three polypeptides: protective factor (PA), lethal factor (LF), and edema factor (EF). PA can bind to various surface receptors of all types of human cells and it internalizes the lethal factor and edema factor subunits of the toxin in the cytosol. In the present study, we cloned and expressed the lef gene of B. anthracis as the lethal part of the toxin in Bacillus subtilis WB600 by a shuttle expression vector PHT4. The rLF made in B. subtilis is efficiently secreted by the host into the culture medium which facilitates downstream processing. The rLF can be used to study cancer treatment. Abbreviations: EF: edema factor; LF: lethal factor; PA: protective factor; rLF: recombinant lethal factor; rPAm: recombinant protective factor mutants; uPA: urokinase-type plasminogen activator; uPAR: urokinase-type plasminogen activator receptor.

National Guidelines for Cognitive Assessment and Rehabilitation of Iranian Traumatic Brain Injury Patients.

BACKGROUND: Individuals with moderate to severe traumatic brain injury (TBI) often have prolonged cognitive impairments, resulting in long-term problems with their real-life activities. Given the urgent need for evidence-based recommendations for neuropsychological management of Iranian TBI patients, the current work aimed to adapt eligible international guidelines for cognitive assessment and rehabilitation of the TBI patients in Iran. METHODS: The project was led by an executive committee, under the supervision of the Iranian Ministry of Health and Medical Education (MOHME). Following a systematic literature search and selection process, four guidelines were included for adaptation. Clinical recommendations of the source guidelines were tabulated as possible clinical scenarios for 90 PICO clinical questions covering all relevant phases of care. After summing up the scenarios, our initial list of recommendations was drafted according to the Iranian patients' conditions. The final decision-making, with the contribution of a national interdisciplinary panel of 37 experts from across the country, was conducted in two rounds using online and offline survey forms (Round 1), and face-to-face and telephone meetings (Round 2). RESULTS: A total of 63 recommendations in six sections were included in the final list of recommendations, among which 24 were considered as key recommendations. In addition, some of the recommendations were identified as fundamental, meaning that proper implementation of the other recommendations is largely dependent on their implementation. CONCLUSION: Iranian health policy makers and rehabilitation program managers are recommended to address some fundamental issues to provide the necessary infrastructure to set up an efficient cognitive rehabilitation service system.

How People Emotionally Respond to the News on COVID-19: An Online Survey.

INTRODUCTION: During the Coronavirus Disease 2019 (COVID-19) outbreak, news media has played an important role in informing people to satisfy their curiosity about this stressful condition. Regular exposure to such stressful news may elicit different emotions in people and engage them in using strategies to control their emotions. In the present study, we aimed at exploring the most common negative emotion(s) experienced by individuals, as well as the most frequent Emotion Regulation (ER) strategies used facing the COVID-19-related news. We also examined whether the variable of personal relevance can moderate these emotional responses. METHODS: 617 individuals living in Tehran who regularly read the news about the COVID-19 from the early stages of spread completed an online survey. After excluding the participants with high scores from the Beck Depression Inventory (>18), data obtained from 443 participants were analyzed in terms of the experienced negative emotions and ER strategies. RESULTS: Anxiety (55.8%) was the most common negative emotion reported by participants facing COVID-19-related news and problem-solving was the most frequent strategy used to control negative emotions. Both groups with high and low personal relevance indicated a similar pattern in experiencing high and low arousal emotions, as well as using ER strategies, and no significant differences were found (X2=0.006, p=0.51; X2=0.14, p=0.39, respectively). We also found that participants with high scores in the resilience scale used an integrative rather than a single approach of the ER strategies (rbp=0.15, p=0.01). CONCLUSION: We found that during the COVID-19 outbreak, news media may have important role in triggering anxiety in people who regularly read the relevant news, and problem-solving was the most frequent strategy among them. Being directly involved with COVID-19 in personal life did not make any differences in the way that individuals emotionally respond to the news. While using an integrative approach in regulating emotion was found in more resilient individuals.

Preliminary Reliability and Validity of the Iranian Computerized Version of Memory Tasks of the Betula Study.

INTRODUCTION: This study aimed to evaluate the reliability and validity of an Iranian computerized memory battery modeled after the Betula study. METHODS: This study aimed to evaluate the reliability and validity of an Iranian computerized memory battery modeled after the Betula study ( Nilsson et al., 1997). The researchers developed this battery as an assessment tool in the Sepidar prospective cohort study. One hundred and ninety-nine participants aged 19-83 years were tested extensively on different aspects of memory. Exploratory factor analysis of the data demonstrated factors similar to those reported by the Betula study. RESULTS: The authors succeeded to converge the cross-sectional findings of the study and the data from longitudinal studies of memory aging by correcting possible cohort effects. Investigating age differences in episodic and semantic memory factor scores corrected by education and socioeconomic status revealed no significant difference between younger and older adults before ages 53 to 60, though linear age-related declines existed thereafter. CONCLUSION: The results support the reliability and construct validity of this computerized battery for memory assessment in Iranian adults.

Influence of metrical structure on learning of positional regularities in movement sequences.

Sequential stimuli are usually perceived to have hierarchical temporal structures. However, some of these structures are only investigated in one type of sequence, regardless of the existing evidence, showing the domain-generality of the representation of these structures. Here, we assess whether the hierarchical representation of regularly segmented action sequences resembles the perceived metrical patterns that organize the representation of events hierarchically in temporally regular sequences. In all our experiments, we presented the participants with sequences of human movements and tested the perception of metrical pattern by segmenting the movement streams into temporally equal groups containing four movements. In Experiment 1, we found that a movement sequence with temporally equal groupings improves the learning of positional regularities inherent within each group of movements. To further clarify the degree to which this learning mechanism is affected by the perceived metrical patterns, we conducted Experiments 2a and 2b, in which the relative saliencies of the first and last positions in the movement groups, respectively, were studied. The results showed that, although in the learning of positional regularities, the rule-conforming first positions are as effective as when both first and last positions are legal, the last positions are not as influential. Based on these findings we conclude that, in grouped sequences, learning of positional regularities may be modulated by the metrical saliency patterns that are imposed by the temporal regularity of the sequential grouping pattern.