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J Bacteriol ; 189(11): 4320-4, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17384185

ABSTRACT

The Burkholderia pseudomallei KHW quorum-sensing systems produced N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.


Subject(s)
Bacterial Outer Membrane Proteins/metabolism , Burkholderia pseudomallei/metabolism , Quorum Sensing/physiology , 4-Butyrolactone/analogs & derivatives , 4-Butyrolactone/metabolism , Bacterial Outer Membrane Proteins/genetics , Burkholderia pseudomallei/genetics , Burkholderia pseudomallei/physiology , Chromatography, High Pressure Liquid , Gene Expression Regulation, Bacterial , Homoserine/analogs & derivatives , Homoserine/metabolism , Lactones/metabolism , Mutation , Quorum Sensing/genetics
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