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1.
Intern Med ; 59(20): 2505-2509, 2020 Oct 15.
Article in English | MEDLINE | ID: mdl-32641665

ABSTRACT

A 70-year-old woman was referred to our department due to a solitary mediastinal tumor which gradually grew near the site of anastomosis for 8 years after radical surgery of esophageal squamous cell carcinoma. It was difficult to distinguish the lymph node recurrence of esophageal cancer from another tumor of unknown primary origin. Endoscopic ultrasound-guided fine-needle aspiration was performed, and the tumor was diagnosed to be neuroendocrine carcinoma. She received concurrent chemoradiotherapy with etoposide plus cisplatin. After the completion of chemoradiotherapy, the tumor disappeared. A solitary growing tumor which develops after radical resection of cancer would be better to be examined histologically in order to make an accurate diagnosis and select the most appropriate treatment.


Subject(s)
Antineoplastic Agents, Phytogenic/therapeutic use , Carcinoma, Neuroendocrine/drug therapy , Carcinoma, Neuroendocrine/radiotherapy , Esophageal Neoplasms/surgery , Esophageal Squamous Cell Carcinoma/surgery , Mediastinal Neoplasms/drug therapy , Mediastinal Neoplasms/radiotherapy , Aged , Carcinoma, Neuroendocrine/physiopathology , Cisplatin/therapeutic use , Esophageal Neoplasms/physiopathology , Esophageal Squamous Cell Carcinoma/physiopathology , Etoposide/therapeutic use , Female , Humans , Lymph Nodes/physiopathology , Mediastinal Neoplasms/physiopathology , Neoplasm Recurrence, Local/physiopathology , Radiotherapy/methods , Treatment Outcome
2.
Clin J Gastroenterol ; 13(5): 902-906, 2020 Oct.
Article in English | MEDLINE | ID: mdl-32557088

ABSTRACT

A 69-year-old woman who had a history of chronic hepatitis C, autoimmune hemolytic anemia and myelodysplastic syndrome was treated with sorafenib at a daily dose of 400 mg for HCC with multiple lung metastases. Nonetheless, elevated serum tumor markers further increased (alpha fetoprotein from 121,100 to 348,660 ng/ml and protein induced by vitamin K absence/antagonist-II from 3435 to 29,357 mAU/ml), and lung metastatic lesions on chest X-ray showed no improvement after 2 months of sorafenib treatment. Sorafenib was discontinued because of adverse events with diarrhea, fatigue, and severe anemia due to bleeding from stomach telangiectasia. Hand-foot syndrome was mild. Thereafter, the tumor markers rapidly decreased to almost normal range, and the lung and liver tumors markedly shrunk and disappeared without any other cancer treatments. Her tumors remained in complete remission for 17 months until an intrahepatic recurrence occurred. This unique course of metastatic HCC indicated that antitumor mechanisms other than the direct anticancer effect of sorafenib contributed to tumor shrinkage.


Subject(s)
Antineoplastic Agents , Carcinoma, Hepatocellular , Liver Neoplasms , Sorafenib , Aged , Antineoplastic Agents/adverse effects , Carcinoma, Hepatocellular/drug therapy , Female , Humans , Liver Neoplasms/drug therapy , Neoplasm Recurrence, Local , Sorafenib/adverse effects
3.
Clin J Gastroenterol ; 13(5): 946-950, 2020 Oct.
Article in English | MEDLINE | ID: mdl-32347471

ABSTRACT

Pancreatic-pleural fistula is a rare but severe complication with pancreatitis. A 50-year old man with heavy alcoholic history was transferred to our hospital due to pancreatic pleural effusion with diffuse pancreatic swelling. MRCP revealed two stenotic parts of main pancreatic duct. We inserted a pancreatic stent, and pleural effusion was improved. However, diffuse pancreatic swelling still remained for 3 months. Autoimmune pancreatitis was suspected because of morphologic appearance and high serum levels of IgG4. We confirmed his illness as Type 1 autoimmune pancreatitis pathologically by EUS-FNA and started steroid administration. Diffuse pancreatic swelling was improved immediately. Pancreatic-pleural fistula did not relapse after removing the pancreatic stent and tapering steroid. This is a first report for pancreatic-pleural fistula caused by autoimmune pancreatitis and successfully treated with pancreatic drainage and steroid.


Subject(s)
Autoimmune Pancreatitis , Pleural Diseases , Drainage , Humans , Male , Middle Aged , Pancreatic Fistula/etiology , Pleural Diseases/complications , Pleural Diseases/drug therapy , Steroids
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