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Tidsskr Nor Laegeforen ; 117(18): 2610-2, 1997 Aug 10.
Article in Norwegian | MEDLINE | ID: mdl-9324814

ABSTRACT

During the autumn of 1995, the National Poisons Information Centre was contacted about several cases of poisoning with Jimson weed (Datura stramonium). Five cases are described here. Upon admission to hospital the patients had moderate to severe anticholinergic symptoms, such as mydriasis, sinus tachycardia, agitation, dry mouth, urine retention, fever, hypertension, hallucinations and seizures. Owing to their agitated behaviour, gastrointestinal decontamination was impossible. Repeated doses of physostigmine (2-3 mg) administered intravenously reversed the anticholinergic features without side-effects. In the most severe case, physostigmine was needed for 18 hours (total dose; 25.5 mg). The patients recovered in a day or two, but mydriasis persisted in many cases.


Subject(s)
Antidotes/administration & dosage , Cholinesterase Inhibitors/administration & dosage , Datura stramonium , Hallucinogens , Physostigmine/administration & dosage , Plant Poisoning/drug therapy , Plants, Medicinal , Plants, Toxic , Substance-Related Disorders/drug therapy , Adolescent , Hallucinogens/poisoning , Humans , Male , Plant Poisoning/diagnosis , Plant Poisoning/physiopathology , Substance-Related Disorders/diagnosis , Substance-Related Disorders/physiopathology
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