ABSTRACT
BACKGROUND: Interferon-associated retinopathy is a rare complication of interferon treatment. It has been well described with the use of interferon-α. METHODS: This study reports a retrospective case series of interferon-ß-associated retinopathy in three patients that were being treated for multiple sclerosis. RESULTS: All cases were characterized by cotton-wool spots or peripheral microaneurysms. One central retinal artery occlusion was observed associated with interferon-ß treatment. Findings improved spontaneously in two of three cases; all three patients elected to continue interferon treatment. CONCLUSION: Patients being treated with interferon-ß should have periodic fundus examinations to determine if they have evidence of interferon-associated retinopathy.
ABSTRACT
BACKGROUND AND OBJECTIVE: For laser-induced chorioretinal venous anastomosis to become a viable treatment option for perfused central retinal vein occlusion, laser parameters must be refined to more reliably create venous anastomoses while minimizing complications. The aim of this study was to determine the lowest argon laser power at which Bruch's membrane and the retinal vein are ruptured in 100% of attempts in the porcine eye. MATERIALS AND METHODS: Testing was performed on 6 eyes of 3 Yorkshire Cross pigs, using an argon green laser. The spot size was 50 microm and the duration was 0.2 seconds for all applications. Twelve laser powers were tested, from 0.5 to 6 W, increasing by increments of 0.5 W. Light microscopy was used to determine the frequency of rupture of Bruch's membrane and the retinal vein for each power. RESULTS: The rupture rate of Bruch's membrane was 0% at 0.5 W, 5% at 1.0 W, 20% at 1.5 W, 70% at 2.0 W, and 100% for all powers from 2.5 to 6.0 W. The rupture rate of the retinal vein was 0% at 0.5 W, 5% at 1.0 W, 30% at 1.5 W, 60% at 2.0 W, 80% at 2.5 W, and 100% for all powers from 3.0 to 6.0 W. CONCLUSION: Argon green laser powers of at least 2.5 and 3.0 W were necessary to rupture Bruch's membrane and the retinal vein, respectively, with a 100% success rate in the porcine eye. Because patients with central retinal vein occlusion have secondary retinal edema and may have lenticular opacity, higher laser powers may be required to achieve a 100% rupture rate of these structures.
