ABSTRACT
BACKGROUND: Superinfections contribute to mortality and length of stay in critically ill COVID-19 patients. The aim of this study was to determine the incidence and pathogen distribution of bacterial and fungal superinfections of the lower respiratory tract (LRTI), urinary tract (UTI) and bloodstream (BSI) and to determine the predictive value of biomarkers of inflammatory response on their ICU survival rates. METHODS: A retrospective observational study that included critically ill COVID-19 patients treated during an 11-month period in a Croatian national COVID-19 hospital was performed. Clinical and diagnostic data were analyzed according to the origin of superinfection, and multivariate regression analysis was performed to determine the predictive values of biomarkers of inflammation on their survival rates. RESULTS: 55.3% critically ill COVID-19 patients developed bacterial or fungal superinfections, and LRTI were most common, followed by BSI and UTI. Multidrug-resistant pathogens were the most common causes of LRTI and BSI, while Enterococcus faecalis was the most common pathogen causing UTI. Serum ferritin and neutrophil count were associated with decreased chances of survival in patients with LRTI, and patients with multidrug-resistant isolates had significantly higher mortality rates, coupled with longer ICU stays. CONCLUSION: The incidence of superinfections in critically ill COVID-19 patients was 55.3%, and multidrug-resistant pathogens were dominant. Elevated ferritin levels and neutrophilia at ICU admission were associated with increased ICU mortality in patients with positive LRTI.
ABSTRACT
BACKGROUND: Currently known data about ultramarathon medical issues has been collected from all combinations of ultramarathon race types (road, trail, etc.) and the population in those studies consists of mixed elite and recreational athletes. There are few studies concerning injuries related to musculoskeletal system injuries in ultramarathon runners. METHODS: The study was conducted on total of 77 elite ultramarathoners based on a questionnaire-based survey. We studied the elite male and female athletes who participated in the 30th IAU 100-km World Championships held in Croatia, in 2018. RESULTS: Ultramarathon runners have higher percentage of lower-leg injuries and rehabilitation of those injuries tend to last longer as ultramarathon runners show specific training habits with less days off and hold a permanent, full-time job and often with a higher academic degree. Furthermore, also the mean age is higher. CONCLUSIONS: Ultramarathoners have a higher percentage of lower-leg injuries than runners who do not run distances beyond a marathon. In addition, rehabilitation tends to last longer. This may well be correlated also to their specific training loads with fewer days off and training whilst holding a permanent full-time job. Often, they also hold a higher academic degree with years spent in the education system which might influence their mindsets on the medical issues they encounter. Also, being older may also have a bearing on injury occurrence and rehabilitation time.
