ABSTRACT
OBJECTIVES: The aim of this study was to describe the relationship between mould exposure induced by moisture damage and mould specific immunoglobulin G antibodies to 20 common mould species and their association with respiratory diseases. MATERIALS AND METHODS: Mould specific immunoglobulin G (IgG) antibodies were monitored in teachers in a follow-up after an extensive mould remediation process in school buildings. IgG antibodies to 20 different microbes were determined from the sera of 26 teachers (19 exposed and 7 references) by enzyme-linked immunosorbent assay (ELISA). The serum samples were drawn twice, firstly at the completion of the remediation in the spring of 1997 and secondly, two years later in the spring of 1999. Health data was collected with self-administered questionnaires. RESULTS: No statistical differences were found in the overall concentrations of 20 mould-specific IgG-antibodies between the study and control groups at the beginning of the study. An association between sinusitis and elevated mould-specific IgG-levels forAspergillus fumigatus, Aspergillus versicolor, Aureobasidium pullulans, Chaetomium globosum, Cladosporium cladosporioides, Phialophora bubakii, Rhodotorula glutinis, Sporobolomyces salmonicolor, Stachybotrys atra, and Tritirachium roseum was found in the study group. CONCLUSIONS: In a two-year follow-up the total concentration of the IgG antibodies for Tr. toseum was lower at the end than at the beginning of the follow-up and this remained significant for the group of teachers with sinusitis. The decrease in mould specific IgG to Cl. cladosporioides, Geotrichum candidum, Ph. bubakii and Rhizopus nigricans was associated with bronchitis. According to our knowledge, this is the first study in which the association between elevated mould specific IgG antibodies and sinusitis was found in the school environment.
