Lateral Orbitofrontal Cortex Encodes Presence of Risk and Subjective Risk Preference During Decision-Making.

Adaptive decision-making requires consideration of objective risks and rewards associated with each option, as well as subjective preference for risky/safe alternatives. Inaccurate risk/reward estimations can engender excessive risk-taking, a central trait in many psychiatric disorders. The lateral orbitofrontal cortex (lOFC) has been linked to many disorders associated with excessively risky behavior and is ideally situated to mediate risky decision-making. Here, we used single-unit electrophysiology to measure neuronal activity from lOFC of freely moving rats performing in a punishment-based risky decision-making task. Subjects chose between a small, safe reward and a large reward associated with either 0% or 50% risk of concurrent punishment. lOFC activity repeatedly encoded current risk in the environment throughout the decision-making sequence, signaling risk before, during, and after a choice. In addition, lOFC encoded reward magnitude, although this information was only evident during action selection. A Random Forest classifier successfully used neural data accurately to predict the risk of punishment in any given trial, and the ability to predict choice via lOFC activity differentiated between and risk-preferring and risk-averse rats. Finally, risk preferring subjects demonstrated reduced lOFC encoding of risk and increased encoding of reward magnitude. These findings suggest lOFC may serve as a central decision-making hub in which external, environmental information converges with internal, subjective information to guide decision-making in the face of punishment risk.

Unraveling Spatial-Spectral Dynamics of Speech Categorization Speed Using Convolutional Neural Networks.

The process of categorizing sounds into distinct phonetic categories is known as categorical perception (CP). Response times (RTs) provide a measure of perceptual difficulty during labeling decisions (i.e., categorization). The RT is quasi-stochastic in nature due to individuality and variations in perceptual tasks. To identify the source of RT variation in CP, we have built models to decode the brain regions and frequency bands driving fast, medium and slow response decision speeds. In particular, we implemented a parameter optimized convolutional neural network (CNN) to classify listeners' behavioral RTs from their neural EEG data. We adopted visual interpretation of model response using Guided-GradCAM to identify spatial-spectral correlates of RT. Our framework includes (but is not limited to): (i) a data augmentation technique designed to reduce noise and control the overall variance of EEG dataset; (ii) bandpower topomaps to learn the spatial-spectral representation using CNN; (iii) large-scale Bayesian hyper-parameter optimization to find best performing CNN model; (iv) ANOVA and posthoc analysis on Guided-GradCAM activation values to measure the effect of neural regions and frequency bands on behavioral responses. Using this framework, we observe that α-ß (10-20 Hz) activity over left frontal, right prefrontal/frontal, and right cerebellar regions are correlated with RT variation. Our results indicate that attention, template matching, temporal prediction of acoustics, motor control, and decision uncertainty are the most probable factors in RT variation.