ABSTRACT
Onychomatricoma is a rare, fibroepithelial tumor of the nail. Although it is benign, unnecessary and excessive treatment, such as extensive or total removal of the nail matrix, has been reported in the past. Recently, it was speculated that onychomatricoma is derived from onychomatricodermis, the dermal stroma of the nail matrix. Excision of the stromal rather than the epithelial component of the tumor is important. However, since the boundary between the normal and diseased stroma is usually unclear, minimal excision at the base of the tumor projection should be sufficient. We report a case of onychomatricoma and suggest a method of surgical treatment that would minimize postoperative deformity of the nail plate.
Subject(s)
Minimally Invasive Surgical Procedures , Nail Diseases , Skin Neoplasms , Humans , Male , Minimally Invasive Surgical Procedures/methods , Nail Diseases/surgery , Nail Diseases/pathology , Nail Diseases/diagnosis , Nails/surgery , Nails/pathology , Neoplasms, Fibroepithelial/surgery , Neoplasms, Fibroepithelial/pathology , Neoplasms, Fibroepithelial/diagnosis , Skin Neoplasms/surgery , Skin Neoplasms/pathology , Skin Neoplasms/diagnosis , AdultSubject(s)
Dermatitis, Allergic Contact , Dermatitis, Occupational , Stomatitis , Tooth Bleaching , Humans , Acrylates , Tooth Bleaching/adverse effects , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Methacrylates , Patch Tests/adverse effectsSubject(s)
Air Pollutants, Occupational/adverse effects , Coffea/adverse effects , Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Seeds/adverse effects , Adrenal Cortex Hormones/therapeutic use , Dermatitis, Allergic Contact/drug therapy , Dermatitis, Allergic Contact/pathology , Dermatitis, Occupational/drug therapy , Dermatitis, Occupational/pathology , Female , Humans , Young AdultSubject(s)
Melanoma , Skin Abnormalities , Skin Neoplasms , Humans , Melanoma/diagnosis , Skin Neoplasms/diagnosisABSTRACT
Tocilizumab (TCZ) is a humanized antihuman interleukin-6 (IL-6) receptor antibody used for the treatment of inflammatory diseases such as rheumatoid arthritis (RA). While TCZ could act as a therapeutic agent, it has a potential for inducing adverse drug events including psoriasis-like eruption. Seven cases with specific reference to TCZ-induced psoriasis eruption have been reported worldwide so far. In these cases, treatments with the same dosage of TCZ were either maintained or discontinued. Herein, we report a case involving a 74-year-old man diagnosed with rheumatoid factor-positive and anti-citrullinated protein antibody-positive RA with comorbidity of atopic dermatitis. TCZ was administered intravenously with oral methotrexate. After the third infusion, the patient developed TCZ-induced psoriasis-like eruptions, which were resolved by shortening the dose interval. Eruption recurrence was not observed after frequent TCZ subcutaneous injection. Our case may help physicians manage TCZ-induced psoriasis-like eruption.
