ABSTRACT
BACKGROUND: We aimed to study the presence of anti-2-glycoprotein I antibodies (anti-2GPI) in patients with systemic lupus erythematosus (SLE) analyzing their relationship with anticardiolipin antibodies (aCL). PATIENTS AND METHOD: 63 patients with SLE and 54 healthy volunteers. Detection of anti-2GPI antibodies was performed by ELISA. RESULTS: 25 (40%) patients with SLE and 1 (2%) control had anti-2GPI antibodies (p < 0.001). 17 patients with aCL (43%) had anti-2GPI antibodies and 4 patients (20%) without aCL were found to have anti-2GPI antibodies (p < 0.05). There was an association between thrombosis and aCL. However, the association between thrombosis and anti-2GPI antibodies was not significant. CONCLUSIONS: Anti-2GPI antibodies are more frequent in SLE and they are more prevalent in patients with aCL. There is an association between thrombosis and aCL but no significant association between thrombosis and anti-2GPI antibodies.
