[Ocular cysticercosis, typical forms and treatment]. / Cysticercose oculaire, formes typiques et traitement.

We report two personal cases of intra ocular cysticercosis typical by their sub retinal and intra vitreous localization. After a short review of epidemiology and biological diagnostic we propose a treatment which associates a medical part with Praziquantel, killing the larva and a surgical part with pars plana vitrectomy allowing the control of the inflammation, contemporary of the larva's death and the intra-vitreous cysticercosis extraction.

[Benign isolated 6th nerve paralysis in children. Developmental aspects apropos of 9 new cases]. / Les paralysies isolées et bénignes du VI nerf crânien chez l'enfant. Aspects évolutifs à propos de 9 nouveaux cas.

Benign isolated VI nerve palsy in children is a rare but now well-established clinical entity. The diagnosis is essentially an exclusion one. We report nine additional cases. The evolution is discussed, with reference to the literature.

Cell lines derived from tumors induced in syngeneic rats by FR 3T3 SV40 transformants no longer synthesize the early viral proteins.

Several SV40-transformed FR 3T3 rat cell lines formed tumors upon inoculation to syngeneic immunocompetent Fisher rats. These tumors, which appeared only after a long latency period, showed a fast rate of growth. Tumor-derived (TD) cell lines were established in culture from several tumors induced by independent transformants, and their properties were analyzed. Though TD cells were highly tumorigenic, their level of transformation in culture was similar to that of the original transformants. They did not synthesize detectable amounts of the two early viral gene products, the large-T and small-T polypeptides. However, the transformation-associated cellular p53 protein was detected in all of them by [35S]methionine labeling and immune precipitation with monoclonal antibodies directed against the mouse p53. Growth in the animal apparently counterselected the cells expressing the early viral proteins, and hence, possibly, the tumor-specific transplantation antigen. This selection was mediated at least in part by the T-cell immune response, as the tumors induced by the same transformants in nu/nu mice still expressed the nuclear T-antigen. Absence of expression of the early viral region was frequently correlated with the loss of the integrated SV40 DNA. Some tumors, however, still contained early viral DNA sequences, which were, in even fewer cases, transcribed into RNA. These results altogether suggest that tumor formation by the FR 3T3-SV40 transformed cells in immunocompetent rats requires two events, the selection for the acquisition of a high tumorigenic potential, and against the expression of the early viral genes. Only the first of these two events was observed upon tumor formation in nude mice.

Lymphoid cell surface interaction structures detected using cytolysis-inhibiting monoclonal antibodies.

We screened monoclonal antibodies obtained by xenogeneic immunization for their capacity to inhibit T cell-mediated cytolysis. These antibodies fell into two classes according to the cell structures they recognized, of 30-35 K and 94-180 K apparent molecular weight, respectively. The main features of these structures and of their interaction with the corresponding antibodies were reviewed. The inhibition of cytolysis by these antibodies was shown to occur mainly at the effector cell level, at the recognition stage of cytolysis, and to depend on the nature of target cells, effector cells, and link between these cells. T cell functions other than cytolysis were also inhibited by some of these antibodies. We considered various possible mechanisms to account for the inhibition of cytolysis by these mAb. We favor an hypothesis based on inhibition by these mAb of lymphoid cell surface interaction structures. This hypothesis was discussed within the general framework of cell interaction structures in immunological and non-immunological experimental systems.