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1.
J Med Imaging Radiat Oncol ; 68(2): 117-125, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37972237

ABSTRACT

INTRODUCTION: Women comprise almost 30% of practising clinical radiologists in Australia. Despite three-quarters of clinical radiologists working in private practice, there is limited research regarding the experience of female radiologists in private practice and issues surrounding work-life balance. The primary aim of this study was to identify gender issues within private radiology and investigate work-life balance, focusing on issues relevant for female practitioners. METHODS: Clinical radiologists working in private practice at five major Australian private radiology service providers were sent an email on behalf of the researchers, containing study information and a link to an online questionnaire. Descriptive statistics, chi-square analysis and Fisher's exact test were used. Binary logistic regression was used to determine odds ratios and 95% confidence intervals. Responses to short-answer questions were analysed manually and grouped into themes. RESULTS: There were consistent gender differences in perceptions of gender and its implication upon working and career progression in radiology private practice. There was near unanimous agreement that private radiologists should be able to work flexible/reduced working hours for a proportionate decrease in pay. Two themes with distinct gender differences related to pay equity and transparency. Key themes relating to work-life balance for private radiologists included workload, setting boundaries and flexibility of work hours in private radiology. CONCLUSION: This preliminary survey highlights areas related to work-life balance and gender issues relevant for female practitioners in private practice radiology in Australia that can be targeted for further investigation and improvement, namely pay equity and transparency, and part-time leadership opportunities.


Subject(s)
Radiology , Work-Life Balance , Humans , Female , Sexism , Australia , Radiography
2.
J Med Imaging Radiat Oncol ; 67(2): 162-169, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36229951

ABSTRACT

INTRODUCTION: Women comprise 31% of the Australian and New Zealand radiology workforce, and 35% of radiology trainees. To date, there has been no study of female representation within clinical radiology subspecialties in Australia and New Zealand. This study aims to quantify female representation among the clinical radiology subspecialty interest groups (SIGs) in Australia and New Zealand. METHODS: A list of SIGs was compiled using the Royal Australian and New Zealand College of Radiologists (RANZCR) website. The executive of each SIG or the RANZCR Standards committee was contacted with a request to provide the number of female versus male members for each subspecialty group and their executive. RESULTS: Six out of 10 SIGs reported a low proportion of female members; this was most pronounced for IRSA (interventional radiology; 7% women), AMSIG (musculoskeletal imaging; 13% women) and CCINR (interventional neuroradiology; 13% women). Female radiologists accounted for >50% of membership in four SIGs: OGSIG (obstetrics/gynaecology imaging; 87% women), BIG (breast imaging; 73% women), ARGANZ (abdominal imaging; 69% women) and ANZSTR (thoracic imaging; 69% women). Female executive representation ranged from 0% (IRSA (interventional radiology) and ANZSNR (neuroradiology)) to 100% (OGSIG (obstetrics/gynaecology imaging)). CONCLUSION: Female representation within the membership and representative leadership of some SIGs is well below parity and active initiatives to improve female representation should be considered.


Subject(s)
Public Opinion , Radiology, Interventional , Humans , Male , Female , New Zealand , Australia , Radiography
3.
Radiology ; 283(3): 644-662, 2017 06.
Article in English | MEDLINE | ID: mdl-28514214

ABSTRACT

The ankle and foot are commonly injured during sporting activities. Clinical diagnosis can at times be challenging, due to the complex anatomy and multiple sites of potential injury. In the athlete, there is a reduced threshold for imaging to clarify diagnosis, guide prognosis, and treatment. Diagnostic imaging is also helpful in evaluating ongoing symptoms in the subacute or chronic setting. © RSNA, 2017.


Subject(s)
Ankle Injuries/diagnostic imaging , Athletic Injuries/diagnostic imaging , Foot Injuries/diagnostic imaging , Joint Capsule/diagnostic imaging , Joint Capsule/injuries , Ligaments, Articular/diagnostic imaging , Ligaments, Articular/injuries , Adult , Female , Humans , Male , Middle Aged , Young Adult
4.
J Bone Joint Surg Am ; 95(10): 895-902, 2013 May 15.
Article in English | MEDLINE | ID: mdl-23677356

ABSTRACT

BACKGROUND: Although pseudotumors have been reported at the sites of well-functioning and painful metal-on-metal hip prostheses, there are no objective data on the magnitude of the adverse reaction. This observational study was performed to investigate the ability of modified magnetic resonance imaging (MRI) to detect and quantify adverse synovial responses in symptomatic and asymptomatic subjects following metal-on-metal hip resurfacing. We hypothesized that the magnitude of the synovial reactions would be greater in symptomatic patients. METHODS: Sixty-nine patients (seventy-four hips) with hip resurfacing were divided into three groups: asymptomatic (twenty-two hips), symptomatic with a mechanical cause (twenty), and unexplained pain (thirty-two). The volume of synovitis was calculated on MRI for all patients. RESULTS: Synovitis was detected in fifteen asymptomatic hips (68%), fifteen (75%) with symptoms with a mechanical causes, and twenty-five (78%) with unexplained pain. The mean volume (and standard deviation) of the synovitis in these groups was 5 ± 7 cm³, 10 ± 16 cm³, and 31 ± 47 cm³, respectively. The coefficient of repeatability between the examiners was 1.8 cm³ for measurement of synovitis. Of the thirteen subjects with revision arthroplasty, six had an adverse local tissue reaction. This subgroup had the highest volumes of synovitis on MRI. CONCLUSIONS: An adverse synovial reaction was detected on MRI in both symptomatic and asymptomatic subjects. We found a larger volume of synovitis in symptomatic patients; this increase reached significance only in the group with an adverse local tissue reaction. Synovial volume on MRI may be a valuable marker in the longitudinal assessment of asymptomatic patients with a metal-on-metal hip resurfacing and in identifying patients with adverse local tissue reaction.


Subject(s)
Arthroplasty, Replacement, Hip/instrumentation , Foreign-Body Reaction/diagnosis , Hip Prosthesis/adverse effects , Magnetic Resonance Imaging , Metal-on-Metal Joint Prostheses/adverse effects , Postoperative Complications/diagnosis , Synovitis/diagnosis , Asymptomatic Diseases , Cohort Studies , Cross-Sectional Studies , Female , Foreign-Body Reaction/etiology , Humans , Male , Middle Aged , Osteolysis/diagnosis , Osteolysis/etiology , Postoperative Complications/etiology , Prosthesis Failure/adverse effects , Reoperation , Reproducibility of Results , Synovitis/etiology
5.
J Magn Reson Imaging ; 37(5): 1005-19, 2013 May.
Article in English | MEDLINE | ID: mdl-23606139

ABSTRACT

Magnetic resonance imaging (MRI) is particularly useful for imaging the wrist due to its superior soft tissue contrast and ability to detect subtle bone marrow changes and occult fractures. A high field (1.5T or greater) strength, dedicated wrist coil, and high in-plane and through-plane resolution must be utilized to successfully visualize the relatively thin cartilage of the wrist. MRI can be used to detect occult carpal bone fractures, identify complications following scaphoid fractures, and assess for avascular necrosis in the setting in Kienböck's and Preiser's disease. MRI is useful to identify secondary soft tissue and chondral pathology in impaction/impingement syndromes. The use of an intermediate-echo time fast spin echo sequence allows for accurate assessment of articular cartilage, allowing evaluation of chondral wear in the setting of primary osteoarthritis and posttraumatic degenerative arthrosis. MRI is the most sensitive imaging modality for the detection of early inflammatory arthropathies and can detect synovitis, bone marrow edema, and early erosions in the setting of negative radiographs.


Subject(s)
Bone Diseases/pathology , Cartilage Diseases/pathology , Fractures, Bone/pathology , Fractures, Cartilage/pathology , Magnetic Resonance Imaging/trends , Wrist Injuries/pathology , Humans
6.
Radiology ; 266(1): 256-60, 2013 Jan.
Article in English | MEDLINE | ID: mdl-23091176

ABSTRACT

PURPOSE: To determine the sensitivity and specificity of lamellated hyperintense synovitis for infection following knee arthroplasty and to determine the inter- and intraobserver variability of this sign at magnetic resonance (MR) imaging. MATERIALS AND METHODS: The purpose of the retrospective case control study was approved by the hospital's institutional review board. MR images from 28 patients with proved infected total knee arthroplasty and 28 patients with noninfected arthroplasty were reviewed by two musculoskeletal radiologists for the presence of lamellated hyperintense synovitis. Cases were rereviewed 2 weeks later by each reader. The sensitivity and specificity were calculated with the initial reads. The κ statistic was used to assess inter- and intraobserver reliability. RESULTS: The sensitivity of lamellated hyperintense synovitis for infection was 0.86-0.92 (95% confidence interval [CI]: 0.75, 0.97) and the specificity was 0.85-0.87 (95% CI: 0.74, 0.94). There was almost perfect interobserver agreement (κ = 0.82; 95% CI: 0.72, 0.93; P < .001) and intraobserver agreement (for reader 1, κ = 0.89 [95% CI: 0.78, 1.00; P < .001] and for reader 2, κ = 0.89 [95% CI: 0.77, 1.00; P < .001]) in the classification of the synovial pattern. CONCLUSION: In this selected series of patients, the presence of lamellated hyperintense synovitis at MR imaging of knee arthroplasty had a high sensitivity and specificity for infection. This sign had high inter- and intraobserver reliability.


Subject(s)
Arthroplasty, Replacement, Knee/adverse effects , Knee Joint/pathology , Magnetic Resonance Imaging/methods , Prosthesis-Related Infections/etiology , Prosthesis-Related Infections/pathology , Synovitis/etiology , Synovitis/pathology , Aged , Feasibility Studies , Female , Humans , Knee Joint/surgery , Male , Middle Aged , Reproducibility of Results , Sensitivity and Specificity
7.
AJR Am J Roentgenol ; 199(4): 884-93, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22997383

ABSTRACT

OBJECTIVE: The objective of our study was to compare the frequency of osseous and soft-tissue abnormalities in patients presenting with hip pain after resurfacing arthroplasty and after total hip arthroplasty (THA), correlate the MRI findings with histologic results, and determine which MRI findings are predictive of aseptic lymphocytic vasculitis-associated lesions. MATERIALS AND METHODS: The MRI examinations of patients with metal-on-metal hip prostheses placed at resurfacing arthroplasty (n=31) or THA (n=29) were reviewed for osteolysis, synovitis, extracapsular disease, synovial pattern, and mode of decompression into adjacent bursae. Regional muscles and tendons were assessed for tendinosis, tear, atrophy, and edema. Histologic and operative findings were reviewed in 19 patients (20 hips) who underwent revision surgery. Chi-square tests were performed to detect differences between the resurfacing arthroplasty and THA groups. The Wilcoxon rank sum test was performed to detect differences in MRI findings in patients with and those without aseptic lymphocytic vasculitis-associated lesions. RESULTS: Synovitis was detected in 77.4% of resurfacing arthroplasty hips and 86.2% of THA hips. Extracapsular disease was present in 6.5% of resurfacing arthroplasty hips and 10.3% of THA hips. Osteolysis was detected in 9.7% of resurfacing arthroplasty hips and 24.1% of THA hips. There was no difference in the incidence of synovitis (p=0.51), osteolysis (p=0.17), or extracapsular disease (p=0.67) between the resurfacing arthroplasty and THA groups. Patients with aseptic lymphocytic vasculitis-associated lesions had higher volumes of synovitis (p=0.04) than patients without aseptic lymphocytic vasculitis-associated lesions. Extracapsular disease and muscle edema were seen only in patients with aseptic lymphocytic vasculitis-associated lesions. CONCLUSION: Synovitis is common in patients with metal-on-metal hip prostheses and occurs with a similar incidence after resurfacing arthroplasty and after THA; osteolysis and extracapsular disease are uncommon. The MRI signs most suggestive of aseptic lymphocytic vasculitis-associated lesions are high volumes of synovitis, extracapsular disease, and intramuscular edema.


Subject(s)
Arthralgia/etiology , Arthroplasty, Replacement, Hip/adverse effects , Hemiarthroplasty/adverse effects , Hip Joint/pathology , Magnetic Resonance Imaging , Metal-on-Metal Joint Prostheses/adverse effects , Female , Humans , Male , Middle Aged , Muscular Diseases/diagnosis , Muscular Diseases/etiology , Nerve Compression Syndromes/diagnosis , Nerve Compression Syndromes/etiology , Osteolysis/diagnosis , Osteolysis/etiology , Reoperation , Synovitis/diagnosis , Synovitis/etiology , Vasculitis/diagnosis , Vasculitis/etiology
8.
AJR Am J Roentgenol ; 199(3): 546-57, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22915394

ABSTRACT

OBJECTIVE: Overuse and traumatic injuries of the elbow are common, occurring in both athletes and nonathletes. This article will discuss the commonly encountered soft-tissue and osseous pathologic abnormalities around the elbow and their imaging appearance on MRI and ultrasound. CONCLUSION: The current treatment of tendon disease of the elbow is reviewed, with a focus on platelet-rich plasma injection.


Subject(s)
Elbow Injuries , Magnetic Resonance Imaging , Tendon Injuries/diagnosis , Adolescent , Athletic Injuries/diagnosis , Athletic Injuries/therapy , Cumulative Trauma Disorders/diagnosis , Cumulative Trauma Disorders/diagnostic imaging , Cumulative Trauma Disorders/therapy , Elbow Joint/innervation , Female , Humans , Ligaments, Articular/injuries , Male , Middle Aged , Nerve Compression Syndromes/diagnosis , Nerve Compression Syndromes/etiology , Osteochondritis Dissecans/diagnosis , Tendon Injuries/diagnostic imaging , Tendon Injuries/therapy , Ultrasonography
9.
J Magn Reson Imaging ; 35(5): 1013-25, 2012 May.
Article in English | MEDLINE | ID: mdl-22499278

ABSTRACT

Magnetic resonance imaging (MRI) is ideally suited to imaging the patient with painful hip arthroplasty due to its superior soft tissue contrast, multiplanar capabilities, and lack of ionizing radiation. MRI is the most accurate imaging modality in the assessment of periprosthetic osteolysis and wear-induced synovitis, and can also assess regional tendons and neurovascular structures. This article discusses the technical aspects of MRI around metallic implants as well as the appearance of potential complications following hip arthroplasty, including osteolysis, wear-induced synovitis, infection, hemarthrosis, fracture, loosening, component displacement, heterotopic ossification, tendinopathy, and neurovascular impingement. The specific complication of metal hypersensitivity following metal-on-metal prostheses is reviewed.


Subject(s)
Arthroplasty, Replacement, Hip , Hip Prosthesis , Magnetic Resonance Imaging/methods , Artifacts , Hemarthrosis/diagnosis , Humans , Metals , Nerve Compression Syndromes/diagnosis , Ossification, Heterotopic/diagnosis , Osteolysis/diagnosis , Postoperative Complications/diagnosis , Prosthesis Failure , Prosthesis-Related Infections/diagnosis , Synovitis/diagnosis , Tendinopathy/diagnosis
10.
J Ultrasound Med ; 31(3): 449-53, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22368135

ABSTRACT

OBJECTIVES: The purpose of this study was to determine the reliability in the analysis of images acquired using a dedicated 3-dimensional (3D) ultrasound transducer and conventional 2-dimensional (2D) images in the detection and characterization of supraspinatus tendon tears. METHODS: Images of the supraspinatus tendon in 42 patients who had undergone 2D and 3D sonography were classified by two readers independently as no tear, full-thickness tear, or partial-thickness tear. When present, the tear size and location were recorded. Inter- and intra-rater reliability for the two data sets were calculated. RESULTS: There was substantial agreement between the two readers in the classification of supraspinatus tendon tears on 2D images (κ = 0.79) but only moderate agreement on 3D images (κ = 0.48). There was moderate to substantial agreement in the classification of tears between the 2D and 3D images for both readers (reader 1, κ = 0.64; reader 2, κ= 0.54). The most common cause of a discordant result was the interpretation of a small hypoechoic region at the footprint as a partial tear on 3D images, compared to a normal appearance on 2D images. CONCLUSIONS: Use of a dedicated 3D ultrasound transducer has poorer inter- and intra-rater reliability for the assessment of supraspinatus tendon tears compared to 2D sonography because of the interpretation of small partial-thickness tears at the footprint on 3D images, a common region affected by anisotropy.


Subject(s)
Imaging, Three-Dimensional , Rotator Cuff Injuries , Rotator Cuff/diagnostic imaging , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Image Interpretation, Computer-Assisted , Magnetic Resonance Imaging , Male , Middle Aged , Reproducibility of Results , Transducers , Ultrasonography
11.
HSS J ; 8(2): 184-9, 2012 Jul.
Article in English | MEDLINE | ID: mdl-23874261

ABSTRACT

Electrodiagnostic studies are used to anatomically localize nerve injuries. These tests help differentiate between cervical radiculopathies, brachial plexopathies, and peripheral nerve injuries. They also help to identify or rule out other underlying neurological diseases and disorders. In this case report, a 22-year-old male swimmer presented with left finger extensor weakness following pull-up exercises. Left wrist extension remained intact. Electrodiagnostic testing revealed a severe but incomplete posterior interosseous neuropathy. Magnetic resonance imaging confirmed inflammation of the nerve in the forearm. Posterior interosseous neuropathy is an uncommon but well-studied condition. Typically, this condition presents with weakness in finger and thumb extension with preserved wrist extension as the extensor carpi radialis longus is innervated proximal to the site of nerve compression in most cases. It is important to understand the anatomic course and distribution of the radial nerve in order to make an accurate diagnosis. Once the anatomy is understood, electrodiagnostic testing may be used to identify the location of nerve injury and exclude other disorders.

12.
AJR Am J Roentgenol ; 197(3): W405-11, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21862766

ABSTRACT

OBJECTIVE: The goal of this study was to evaluate the quality of images obtained with a prototype imaging technique, multiacquisition variable-resonance image combination (MAVRIC), compared with fast spin-echo (FSE) images in the evaluation of patients who have undergone hip, shoulder, or knee arthroplasty. MATERIALS AND METHODS: MRI with metal-artifact reduction FSE and MAVRIC sequences was performed in the care of 122 patients who had undergone 74 hip, 27 shoulder, and 21 knee arthroplasties. The FSE and MAVRIC images were subjectively graded for visualization of the synovium, prosthesis-bone interface, and hip abductors or supraspinatus tendon. The presence of synovitis, osteolysis, or supraspinatus tendon tear was recorded. RESULTS: Visualization of the synovium was significantly better on MAVRIC images than on FSE images of the hip (p < 0.0001), shoulder (p < 0.01), and knee (p < 0.01). Synovitis was detected only on the MAVRIC images of nine subjects (12%) who had undergone hip arthroplasty and five subjects (18%) who had undergone shoulder arthroplasty. Visualization of the periprosthetic bone was significantly better on MAVRIC images of the hip (p < 0.0001), shoulder (p < 0.0001), and knee (p < 0.01). Osteolysis was detected only on the MAVRIC images of 12 subjects (16%) who had undergone hip arthroplasty, six (22%) who had undergone shoulder arthroplasty, and five (24%) who had undergone knee arthroplasty. Visualization of the supraspinatus tendon was significantly better on MAVRIC images (p < 0.0001). Supraspinatus tendon tears in 12 subjects (44%) were detected only on MAVRIC images. CONCLUSION: MAVRIC complements the information on FSE images after arthroplasty and is a useful additional sequence, particularly when there is concern about synovitis, periprosthetic osteolysis, or the presence of a supraspinatus tendon tear.


Subject(s)
Arthroplasty, Replacement , Image Enhancement/methods , Image Interpretation, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Postoperative Complications/diagnosis , Adult , Aged , Aged, 80 and over , Artifacts , Female , Humans , Imaging, Three-Dimensional , Male , Metals , Middle Aged , Statistics, Nonparametric
13.
Orthop Clin North Am ; 42(2): 195-205, viii, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21435495

ABSTRACT

Conventional radiography is the primary imaging modality to evaluate the condition of hip resurfacing implants and the preferred method of assessing implant stability over time. Radiographs assess the angle of inclination of the femoral and acetabular components, implant stability, and femoral neck narrowing. Ultrasonography detects solid or soft tissue masses adjacent to the implant. Magnetic resonance imaging (MRI) detects osteolysis and complications in the periprosthetic soft tissues such as wear-induced synovitis, periprosthetic collections, neurovascular compression, and quality of the muscle and tendons of the rotator cuff of the hip. For pain after hip resurfacing, early use of optimized MRI is recommended.


Subject(s)
Arthroplasty, Replacement, Hip , Diagnostic Imaging , Arthroplasty, Replacement, Hip/adverse effects , Femur Neck/pathology , Hip Joint/diagnostic imaging , Hip Joint/pathology , Humans , Magnetic Resonance Imaging , Metals , Ossification, Heterotopic/epidemiology , Pelvis/diagnostic imaging , Radiography , Synovitis/diagnosis , Ultrasonography
14.
J Med Imaging Radiat Oncol ; 54(5): 450-6, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20958943

ABSTRACT

Fishtail deformity of the elbow is characterised by a contour abnormality of the distal humerus, which develops when the lateral trochlear ossification centres fails to develop or resorbs. It is an uncommon complication usually following a distal humeral fracture in childhood. Whilst initially presumed to be a benign condition, long-term follow-up suggests that patients with fishtail deformity are prone to functional impairment, ongoing pain and the development of early osteoarthrosis. This paper reviews the imaging findings in fishtail deformity, the proposed aetiology and the potential long-term complications.


Subject(s)
Humeral Fractures/complications , Humeral Fractures/diagnosis , Humerus/injuries , Joint Deformities, Acquired/diagnosis , Joint Deformities, Acquired/etiology , Child , Epiphyses/injuries , Humans , Magnetic Resonance Imaging , Osteoarthritis/diagnosis , Osteoarthritis/etiology , Osteonecrosis/diagnosis , Osteonecrosis/etiology , Tomography, X-Ray Computed
15.
Magn Reson Imaging Clin N Am ; 17(4): 617-38, v, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19887293

ABSTRACT

MR imaging is a useful modality for evaluating athletes presenting with elbow pain. Osteochondral injuries and ligamentous injuries are well seen on MR imaging. Ligamentous injuries may be associated with clinical instability syndromes, the secondary signs of which may be evident on MR images. Enthesopathies and distal biceps tendon injuries are common clinical problems that may be seen in both professional and recreational athletes. Nerve compression syndromes may be investigated using MR imaging; however, the usual aim of imaging is to exclude an underlying space-occupying lesion. This article reviews the basic anatomy of the elbow joint and discusses the common osteochondral injuries, ligamentous injuries, instability syndromes, and tendinous pathologies at the elbow joint. The role of imaging in compressive neuropathies is briefly discussed.


Subject(s)
Athletic Injuries/diagnosis , Cumulative Trauma Disorders/diagnosis , Elbow Injuries , Forearm Injuries/diagnosis , Magnetic Resonance Imaging/methods , Athletic Injuries/physiopathology , Cumulative Trauma Disorders/physiopathology , Elbow Joint/anatomy & histology , Elbow Joint/physiopathology , Forearm Injuries/physiopathology , Humans , Ligaments/injuries , Ligaments/physiopathology , Nerve Compression Syndromes/diagnosis , Nerve Compression Syndromes/physiopathology , Tendon Injuries/diagnosis , Tendon Injuries/physiopathology
16.
J Vasc Surg ; 42(5): 912-8, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16275447

ABSTRACT

OBJECTIVE: This study compared the hospital and follow-up costs of patients who have undergone endovascular (EVAR) or open (OR) elective abdominal aortic aneurysm repair. METHODS: The records of 195 patients (EVAR, n = 55; OR, n = 140) who underwent elective aortic aneurysm repair between 1995 and 2004 were reviewed. Primary costing data were analyzed for 54 EVAR and 135 OR patients. Hospital costs were divided into preoperative, operative, and postoperative costs. Follow-up costs for EVAR patients were recorded, with a median follow-up time of 12 months. RESULTS: Mean preoperative costs were slightly higher in the EVAR group (AU $961/US $733 vs AU $869/US $663; not significant). Operative costs were significantly higher in the EVAR group (AU $16,124/US $12,297 vs AU $6077/US $4635; P < .001); this was entirely due to the increased cost of the endograft (AU $10,181/US $7,765 for EVAR vs AU $476/US $363 for OR). Postoperative costs were significantly reduced in the EVAR group (AU $4719/US $3599 vs AU $11,491/US $8,764; P < .001). Total hospital costs were significantly greater in the EVAR group (AU $21,804/US $16,631 vs AU $18,437/US $14,063; P < .001). The increase in total hospital costs was due to a significant difference in graft costs, which was not offset by reduced postoperative costs. The average follow-up cost per year after EVAR was AU $1316/US $999. At 1 year of follow-up, EVAR remained significantly more expensive than OR (AU $23,120/US $17,640 vs AU $18,510/US $14,122; P < .001); this cost discrepancy increased with a longer follow-up. CONCLUSIONS: EVAR results in significantly greater hospital costs compared with OR, despite reduced hospital and intensive care unit stays. The inclusion of follow-up costs further increases the cost disparity between EVAR and OR. Because EVAR requires lifelong surveillance and has a high rate of reintervention, follow-up costs must be included in any cost comparison of EVAR and OR. The economic cost, as well as the efficacy, of new technologies such as EVAR must be addressed before their widespread use is advocated.


Subject(s)
Angioscopy/economics , Aortic Aneurysm, Abdominal/surgery , Hospital Costs/trends , Laparotomy/economics , Vascular Surgical Procedures , Aged , Aortic Aneurysm, Abdominal/economics , Australia , Cost-Benefit Analysis/trends , Female , Follow-Up Studies , Humans , Male , Middle Aged , Retrospective Studies , Time Factors , Vascular Surgical Procedures/economics , Vascular Surgical Procedures/methods
17.
Neurosci Lett ; 362(3): 182-4, 2004 May 27.
Article in English | MEDLINE | ID: mdl-15158009

ABSTRACT

Iron-mediated oxidative stress occurs in a wide variety of neurological disorders. The present study has investigated whether melatonin can alter the proportion of neurons that die in the 24 h period following 1.0 microl intracortical injections of 1.0 mM ferric ammonium citrate (FAC) or 0.9% saline. Rats which received systemic infusions of melatonin (5 mg/kg body weight per day) displayed a 40% reduction (P = 0.019) in the proportion of neurons killed by FAC. By contrast, reduction of endogenous melatonin by continuous light exposure did not significantly affect the extent of neuronal death. Furthermore, elevated or reduced melatonin levels did not alter the number of neurons killed by saline injections. We conclude that pharmacological concentrations of melatonin protect neurons against iron-induced injury.


Subject(s)
Cell Death/drug effects , Cerebral Cortex/cytology , Ferric Compounds/toxicity , Melatonin/pharmacology , Neurons/drug effects , Quaternary Ammonium Compounds/toxicity , Animals , Cell Count/methods , Cerebral Cortex/drug effects , Dose-Response Relationship, Drug , Drug Interactions , Female , Fluoresceins , Fluorescent Dyes , Neurons/cytology , Organic Chemicals , Rats , Rats, Wistar
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