Subject(s)
Neoplasms/prevention & control , Oncogenes , Preventive Medicine , Humans , Neoplasms/genetics , Primary PreventionABSTRACT
Nineteen cases of intracranial ependymal tumors were reviewed to examine the prognostic factors influencing survival of the patients with this disease. The two most important predictive factors in relation to survival status were a histologic grade of tumors and a presence of hydrocephalus. The clinicopathological correlation in this study has supported the view of two distinct ependymal tumors; more curable ependymomas and highly malignant ependymoblastomas .
Subject(s)
Brain Neoplasms/classification , Ependymoma/classification , Adolescent , Adult , Brain Neoplasms/complications , Brain Neoplasms/mortality , Child , Ependymoma/complications , Ependymoma/mortality , Female , Humans , Hydrocephalus/etiology , Male , Neoplasm Recurrence, Local , Prognosis , Sex FactorsABSTRACT
A prospectively randomized trial in advanced gastric and pancreatic carcinoma compared multi-drug chemotherapy, with and without radiotherapy to the local lesion, in terms of median survival and toxicity. Of 29 patients with gastric adenocarcinoma, 14 were randomized to receive 5-FU and Methyl-CCNU, and 15 to receive 5-FU and local radiotherapy to a dose of 4600 rad, and then Methyl-CCNU. Thirty patients with advanced adenocarcinoma of the pancreas were similarly randomized. There was no significant difference between the two arms of the gastric or pancreatic adenocarcinoma groups, with a median survival of 13 months and 11.5 months respectively in gastric carcinoma, and 7.8 months and 7.3 months in pancreatic carcinoma. Complications were minimal in both groups. There was more hematopoietic depression in the radiation-treated patients, but none had radiotherapy discontinued because of toxicity.
Subject(s)
Adenocarcinoma/therapy , Fluorouracil/administration & dosage , Nitrosourea Compounds/administration & dosage , Pancreatic Neoplasms/therapy , Semustine/administration & dosage , Stomach Neoplasms/therapy , Clinical Trials as Topic , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Male , Middle Aged , Prognosis , Prospective Studies , Radiotherapy DosageABSTRACT
Fifty-four patients with oligodendroglioma presented in the past 15 years. In contrast to some widely taught concepts, oligodendrogliomas occured largely in the frontotemporal area of both cerebral hemispheres with two peaks of age incidence: one small peak in childhood, and the highest incidence in the middle-aged adult. Seizures, either major and/or minor, were the most common clinical manifestations (average 87%). Cerebral angiography and pneumography were the most reliable and useful diagnostic procedures, as well as the promising CAT scan. All 24 patients who underwent combined modalities of treatment with radical surgery and postoperative radiation therapy survived at least five years, and 2 out of 11 patients treated by surgery alone failed to survive the five-year follow-up period in addition to two recurrences. Postoperative radiation treatment is considered quite effective and indicated in most cases because complete removal of the tumor is not always possible.
