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Fitoterapia ; 151: 104879, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33689876

ABSTRACT

Swertia mileensis, known as Qing-Ye-Dan (QYD), has been documented in Chinese Pharmacopoeia to cure hepatitis. Interestingly, its announced main active component, swertiamarin, could not be detected in the decoction, which indicated that the efficacy of QYD might be attributed to heat-transformed products of swertiamarin (HTPS). Further investigation on HTPS led to the isolation of sweritranslactone D (1), a novel secoiridoid dimer possessing a tetracyclic lactone skeleton, with better hepatoprotective activity than N-acetyl-L-cysteine in vitro.


Subject(s)
Chemical and Drug Induced Liver Injury/drug therapy , Hot Temperature , Iridoid Glucosides/chemistry , Lactones/chemistry , Protective Agents/pharmacology , Pyrones/chemistry , Animals , Cell Line , Drugs, Chinese Herbal , Humans , Mice , Molecular Structure , Protective Agents/isolation & purification , Swertia/chemistry
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